DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pfrx and pfkfb3

DIOPT Version :9

Sequence 1:	NP_477451.1	Gene:	Pfrx / 32938	FlyBaseID:	FBgn0027621	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_012814166.1	Gene:	pfkfb3 / 100216216	XenbaseID:	XB-GENE-963652	Length:	510	Species:	Xenopus tropicalis

Alignment Length:	495	Identity:	250/495 - (50%)
Similarity:	332/495 - (67%)	Gaps:	24/495 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 LRKLLPPTSETVMTKPFPIRGERTIADCTTPHVIAMVGLPARGKTFISKKLARYLNWIGISTRVF 288
            ::|:..|..| :...|..:.|.:.   ..:|.||.||||||||||:|||||.|||||.|:.|:||
Frog    10 IKKIWLPRDE-LPQLPINVGGPQF---ANSPTVIVMVGLPARGKTYISKKLTRYLNWSGVPTKVF 70

  Fly   289 NLGEYRRHATTAYKSHEFFRADNEEAMAIRNRCANQALHDSCDWLLSGQGSIAVFDATNSTRDRR 353
            |:|||||.|...:.||:|||:||:|||.||..||..||.|...:|....|.||||||||:||:||
Frog    71 NVGEYRREAVKDFSSHDFFRSDNKEAMKIRRHCALAALADVKSYLTKEGGQIAVFDATNTTRERR 135

  Fly   354 QLIHDIVVKQHGFRLFFVESICDDPQIIEQNILEVKVSSPDYLNMNTELVVRDFLQRIEHYEERY 418
            .::.|. .|::.|::||:||:||||.::..|:||||:|||||....:...:.||::||..|:..|
Frog   136 SIVVDF-AKENEFKVFFIESVCDDPAVVASNVLEVKLSSPDYKGCTSNEALEDFMKRINCYKNSY 199

  Fly   419 QPID-EVTESHLSFMKVYNAGKKVVVYNNEGHVESRIVYYLMNIHITPRTIYLTRHGESEYNLSG 482
            :|:| :..:..||.:.|.:.|::.:|...:.|::|:|||||||||:.||.|||.|.||||.||..
Frog   200 EPLDPDQHDRDLSMIIVIDVGRRFLVNRVQDHIQSKIVYYLMNIHVQPRCIYLCRAGESESNLKE 264

  Fly   483 LIGGDSNLSARGHQYANALSTFIAQQQIDGLRVWTSWMKRAIQTVADVKAPQERWKALNEIDAGH 547
            .|||||.||.||.::|.||..::..|.:..|:||||.:||.|||...:|.|.|:||||||:|||.
Frog   265 KIGGDSGLSHRGKKFAVALKKYVEDQNLKELKVWTSQLKRTIQTAEALKMPYEQWKALNELDAGV 329

  Fly   548 CEEMTYEQIKEKFPEEFKARDVNKFAYRYPRGESYEDLVARLEPVIMELERQGNVLVVSHQAVLR 612
            |||.|||:|||.:|||:..|..:|:.||||.||||:|||.|||||||||||||||||:.||||:|
Frog   330 CEEKTYEEIKELYPEEYALRAQDKYHYRYPSGESYQDLVQRLEPVIMELERQGNVLVICHQAVMR 394

  Fly   613 CLFAYFLDKSADELPYLYVPLHTVIKLTPVAYGCKVEHIKLPIDAVDTHR----------PKPKI 667
            ||.:|||||.|||:|||..|||:::||||.||||.||.:...:|||:|||          |.|.:
Frog   395 CLLSYFLDKPADEMPYLKCPLHSMLKLTPFAYGCHVEIVPFNVDAVNTHRDRIIEDCKKGPNPLM 459

  Fly   668 PGDVSEPGLDGLSGELVAPDGVGKVLIVGDDVATATNGNG 707
            ..:...|        |.:|:...|..|...:...|.:.:|
Frog   460 RRNSVTP--------LASPEPTKKARINSFEEFAACSSHG 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:279872	110/211 (52%)
		AAA_33	256..412	CDD:290396	88/155 (57%)
		His_Phos_1	468..651	CDD:278716	118/182 (65%)
pfkfb3	XP_012814166.1	6PF2K	29..247	CDD:334602	111/221 (50%)
pfkfb3	XP_012814166.1	His_Phos_1	250..431	CDD:366010	116/180 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I1721
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1139
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232517at33208
OrthoFinder	1	1.000	-	-		FOG0000312
OrthoInspector	1	1.000	-	-		otm48632
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1920
SonicParanoid	1	1.000	-	-		X325
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.090