DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pcm and XRN1

DIOPT Version :9

Sequence 1:	NP_001162796.1	Gene:	pcm / 32935	FlyBaseID:	FBgn0020261	Length:	1613	Species:	Drosophila melanogaster
Sequence 2:	NP_011342.1	Gene:	XRN1 / 852702	SGDID:	S000003141	Length:	1528	Species:	Saccharomyces cerevisiae

Alignment Length:	1647	Identity:	495/1647 - (30%)
Similarity:	773/1647 - (46%)	Gaps:	356/1647 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVPKFFRYISERYPCLSELAREHCIPEFDNLYLDMNGIVHNCSHPDDNNIHFHLEEEQIFQEIF 65
            ||:||||||||||:|.:.:|.....||||||||||||.|:|||:|.:|:::...|.||::|.:|.
Yeast     1 MGIPKFFRYISERWPMILQLIEGTQIPEFDNLYLDMNSILHNCTHGNDDDVTKRLTEEEVFAKIC 65

  Fly    66 NYVDKLFYLIKPQRLFFLSVDGVAPRAKMNQQRSRRFRTAREAEQQEAKAAQRG-ELREHERFDS 129
            .|:|.||..|||:::|::::|||||||||||||:||||||.:||:...||.:.| |:.:.|.|||
Yeast    66 TYIDHLFQTIKPKKIFYMAIDGVAPRAKMNQQRARRFRTAMDAEKALKKAIENGDEIPKGEPFDS 130

  Fly   130 NCITPGTEFMVRLQEGLRAFLKTKISTDPLWQRCTVILSGQEAPGEGEHKIMDYIRYMKTQPDYD 194
            |.||||||||.:|.:.|:.|:..|||.|..|:...:|.||.|.|||||||||::||::|:|.|::
Yeast   131 NSITPGTEFMAKLTKNLQYFIHDKISNDSKWREVQIIFSGHEVPGEGEHKIMNFIRHLKSQKDFN 195

  Fly   195 PNTRHCLYGLDADLIILGLCTHELHFVVLREEVKFG-RNVKRTSVEETRFFLLHLGLLREYLELE 258
            .|||||:||||||||:|||.||..||.:|||||.|| ||.::.|:|...|:||||.|||||:|||
Yeast   196 QNTRHCIYGLDADLIMLGLSTHGPHFALLREEVTFGRRNSEKKSLEHQNFYLLHLSLLREYMELE 260

  Fly   259 FDALRTD-EHKLDIAQLIDDWVLMGFLVGNDFIPHLPCLHISSNALPLLYRTYIGIYPTLGGNIN 322
            |..:..: :.:.:..:::||::|:.|::||||:|:||.||::..|.|:|.:|:........|.||
Yeast   261 FKEIADEMQFEYNFERILDDFILVMFVIGNDFLPNLPDLHLNKGAFPVLLQTFKEALLHTDGYIN 325

  Fly   323 ENGKLNLRRLQIFISALTEVELDHFKEHADDLKYMNNKSEAFDMD-------------------- 367
            |:||:||:||.::::.|::.||.:|::...|:::.|.:.|...::
Yeast   326 EHGKINLKRLGVWLNYLSQFELLNFEKDDIDVEWFNKQLENISLEGERKRQRVGKKLLVKQQKKL 390

  Fly   368 VGEITE------------------------SQNLDS------------DLGALI--NKSMLLYD- 393
            :|.|..                        .::||.            |||..|  :||...|.
Yeast   391 IGSIKPWLMEQLQEKLSPDLPDEEIPTLELPKDLDMKDHLEFLKEFAFDLGLFITHSKSKGSYSL 455

  Fly   394 ---------DDSEEDCSD------------ENAVLLKE--------------FQNYKRNFYRNKF 423
                     |::||:..:            :||:::::              |:.:|..:|.:|.
Yeast   456 KMDLDSINPDETEEEFQNRVNSIRKTIKKYQNAIIVEDKEELETEKTIYNERFERWKHEYYHDKL 520

  Fly   424 K-RDPNDELIEELCHHYVNALQWVLDYYYRGVQSWDWYYPFHYTPFISDL-KNIEQVEIAFHMGT 486
            | ...::|.:.:|...||..|||||.|||||..||.||||.||.|.|||| |.::| :|.|.:..
Yeast   521 KFTTDSEEKVRDLAKDYVEGLQWVLYYYYRGCPSWSWYYPHHYAPRISDLAKGLDQ-DIEFDLSK 584

  Fly   487 PFLPFQQLLAVLPAASAKLLPVAYHDLMLLPTSPLAEFYPLEFESDLNGKKHDWEAVVLIPFIDE 551
            ||.|||||:||||..|..|:|.|:..||....||:.:|||.|.:.|.|||..||||||||.|:||
Yeast   585 PFTPFQQLMAVLPERSKNLIPPAFRPLMYDEQSPIHDFYPAEVQLDKNGKTADWEAVVLISFVDE 649

  Fly   552 GRLLAAMLPCEAQLSLEERERNRHGPMYVYKYSTVAQGPMPAYPPLRALPV---------LYCTE 607
            .||:.||.|...:||.||:.||:.|...:|.::       |....|...|:         .:|.|
Yeast   650 KRLIEAMQPYLRKLSPEEKTRNQFGKDLIYSFN-------PQVDNLYKSPLGGIFSDIEHNHCVE 707

  Fly   608 -----VAKWSHEIAVNLPYSVCIELPNA-ARTVFFPGFPTMQHLPFDFELRNDRVKVFEQVSRNQ 666
                 :...|.||...|       |||| .......||||:..|||...|..:...||:|.|:.|
Yeast   708 KEYITIPLDSSEIRYGL-------LPNAKLGAEMLAGFPTLLSLPFTSSLEYNETMVFQQPSKQQ 765

  Fly   667 NIVLKPRKRQLED-------TLTAVASQYLGKVIHVGWPHLVKAIVVRVATRDQRVDSEGITL-- 722
            ::||     |:.|       ||...:.::|.|||:..||:|.::.:|.:        ::|.|:
Yeast   766 SMVL-----QITDIYKTNNVTLEDFSKRHLNKVIYTRWPYLRESKLVSL--------TDGKTIYE 817

  Fly   723 ----NDSRRF-------DSECKALQEHFINRMGIQFANYDVLVYVRTFAGNSTEFRDKGALMVRD 776
                ||.::|       :::.|.|.....|.|...:|.... |.:......:|.|...|  :|||
Yeast   818 YQESNDKKKFGFITKPAETQDKKLFNSLKNSMLRMYAKQKA-VKIGPMEAIATVFPVTG--LVRD 879

  Fly   777 S-------WSSSVTGYPAQGVVADLTVWERMRKNF--LNVEHYFPVGSTIFLITDPYYGSEGTVQ 832
            |       :|.:...||.|.||..:...:...|..  :.:|..||:.|.:..:.|..||.|.|:.
Yeast   880 SDGGYIKTFSPTPDYYPLQLVVESVVNEDERYKERGPIPIEEEFPLNSKVIFLGDYAYGGETTID 944

  Fly   833 DPRLAYTNG-RIQVSI---MVRPEPKVNAARQLQEERDRDYLSTFQVCNLLRISGRTLGRLSGTV 893
                .|::. |:::::   .:..||.:...|...:.:...|..::.|...:.:....|.:::...
Yeast   945 ----GYSSDRRLKITVEKKFLDSEPTIGKERLQMDHQAVKYYPSYIVSKNMHLHPLFLSKITSKF 1005

  Fly   894 WVVLGPRRQKMENVTKH-NIGLQLKYPRQNEERAGYCFRTNNQWYYSSLAVDLMRNYCQRYPDVI 957
            .:.        :...|| |:|:.:|:..::::..||..|....|.||:|.::|::.|.|.:||.
Yeast  1006 MIT--------DATGKHINVGIPVKFEARHQKVLGYARRNPRGWEYSNLTLNLLKEYRQTFPDF- 1061

  Fly   958 DFFGDSNDRAEFVFEQDVFPNAV---GHRRVEELANWVRQQPHMKVERISCGSKTVCRETIELLI 1019
             ||..|....:....:|:||:..   ....::.:..|:: ....|...:|..|.::.:.:    |
Yeast  1062 -FFRLSKVGNDIPVLEDLFPDTSTKDAMNLLDGIKQWLK-YVSSKFIAVSLESDSLTKTS----I 1120

  Fly  1020 AAVDDLRSLPVKHVK--------------LQVKPHLLIKPNVTLPDVYRSKRPVRLFDRVVIVRT 1070
            |||:|       |:.              .:|....::.|..:.. :.||:: ..|.||||.::.
Yeast  1121 AAVED-------HIMKYAANIEGHERKQLAKVPREAVLNPRSSFA-LLRSQK-FDLGDRVVYIQD 1176

  Fly  1071 IYMVPVGTKGTVIGIHPVTDPNPVRLECVHAVDTFCKVLFDSPVPNCNNI-------HGIAEDR- 1127
            ...||:.:||||:|...::....:            :||||..:...||.       .|:..|.
Yeast  1177 SGKVPIFSKGTVVGYTTLSSSLSI------------QVLFDHEIVAGNNFGGRLRTNRGLGLDAS 1229

  Fly  1128 ----------VYKVPEIALVIIKTDEEGKKQNDCELPVRDPQPNQAQDEPVRATSSRYVTAAGST 1182
                      :|........:.|..:...:.|:.:...:.|...|::::
Yeast  1230 FLLNITNRQFIYHSKASKKALEKKKQSNNRNNNTKTAHKTPSKQQSEEK---------------- 1278

  Fly  1183 SVPITMKTQISD--EFVKTRSDPIARTDSYKPSSEPKPVPVPEQITN---WRERVSTPTNK---P 1239
                ..|.:..|  .|:|            |.::|..    .|.:.|   ..::.|.|..|   .
Yeast  1279 ----LRKERAHDLLNFIK------------KDTNEKN----SESVDNKSMGSQKDSKPAKKVLLK 1323

  Fly  1240 QPAPNNWRINRSSSRQQGGSIFVAPPTKTPDAAASTASTAFTAASSATLTPLDQTLAL------M 1298
            :||      .:||...|   :.:|...|.|....:.|.:.|.|.::.....:...|.:      |
Yeast  1324 RPA------QKSSENVQ---VDLANFEKAPLDNPTVAGSIFNAVANQYSDGIGSNLNIPTPPHPM 1379

  Fly  1299 SVLG-----------VGEDQSSPP--------LQEAVQQQRP-PLLQQQRAPFP-----GQMPNL 1338
            :|:|           ||...:.||        |......|.| |.:.....|.|     ||..:.
Yeast  1380 NVVGGPIPGANDVADVGLPYNIPPGFMTHPNGLHPLHPHQMPYPNMNGMSIPPPAPHGFGQPISF 1444

  Fly  1339 PKPPLFWQQEAQKQEALQQEAQQQEAQK----KQQQAHAQMEPERINSQHFYRSGQTGAALNQPP 1399
            |.||.......|....:..|.:.|:.:|    ||....:.:..|..||    |.|:.     :|.
Yeast  1445 PPPPPMTNVSDQGSRIVVNEKESQDLKKFINGKQHSNGSTIGGETKNS----RKGEI-----KPS 1500

  Fly  1400 LGAPSKRQWHEWVHPRMQHANA 1421
            .|..|.    |...|:.| :||
Yeast  1501 SGTNST----ECQSPKSQ-SNA 1517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pcm	NP_001162796.1	XRN1	1..843	CDD:227382	366/985 (37%)
pcm	NP_001162796.1	XRN_N	1..225	CDD:281193	130/224 (58%)
XRN1	NP_011342.1	XRN1	1..955	CDD:227382	367/988 (37%)
		XRN1_D2_D3	918..1005	CDD:408140	17/90 (19%)
		Xrn1_D3	1087..1156	CDD:408022	12/80 (15%)
		SH3_12	1163..1233	CDD:407961	20/82 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346412
Domainoid	1	1.000	285	1.000	Domainoid score	I248
eggNOG	1	0.900	-	-		E1_COG5049
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5894
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54191
OrthoFinder	1	1.000	-	-		FOG0006565
OrthoInspector	1	1.000	-	-		otm46503
orthoMCL	1	0.900	-	-		OOG6_100417
Panther	1	1.100	-	-	LDO	PTHR12341
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4229
SonicParanoid	1	1.000	-	-		X4804
TreeFam	1	0.960	-	-
	14	13.740