DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pcm and XRN3

DIOPT Version :9

Sequence 1:	NP_001162796.1	Gene:	pcm / 32935	FlyBaseID:	FBgn0020261	Length:	1613	Species:	Drosophila melanogaster
Sequence 2:	NP_565114.1	Gene:	XRN3 / 843900	AraportID:	AT1G75660	Length:	1020	Species:	Arabidopsis thaliana

Alignment Length:	831	Identity:	280/831 - (33%)
Similarity:	406/831 - (48%)	Gaps:	203/831 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVPKFFRYISERYPCL-SELAREHCIP------------------EFDNLYLDMNGIVHNCSHP 46
            ||||.|:|:::|:||.| :::..|..:.                  |:||||||||||:|.|.||
plant     1 MGVPSFYRWLAEKYPLLVADVIEEEPVEIEGIKIPVDTSKPNPNNLEYDNLYLDMNGIIHPCFHP 65

  Fly    47 DDNNIHFHLEEEQIFQEIFNYVDKLFYLIKPQRLFFLSVDGVAPRAKMNQQRSRRFRTAREAEQQ 111
            :|.......||  :||.:|:|:|:||.:::|::|.::::||||||||||||||||||:|::|..
plant    66 EDRPSPTTFEE--VFQCMFDYIDRLFVMVRPRKLLYMAIDGVAPRAKMNQQRSRRFRSAKDASD- 127

  Fly   112 EAKAAQRGELREH-ER-------------FDSNCITPGTEFMVRLQEGLRAFLKTKISTDPLWQR 162
              .||:...|||. ||             ||||.||||||||..|...|:.::..:::.|..|:.
plant   128 --AAAEEERLREEFEREGRRLPPKVDSQVFDSNVITPGTEFMGVLSIALQYYVHLRLNHDVGWKN 190

  Fly   163 CTVILSGQEAPGEGEHKIMDYIRYMKTQPDYDPNTRHCLYGLDADLIILGLCTHELHFVVLREEV 227
            ..||||....|||||||||.|||..:..|.:||||||||||||||||:|||.|||:||.:|||.|
plant   191 IKVILSDANVPGEGEHKIMSYIRLQRNLPGFDPNTRHCLYGLDADLIMLGLATHEVHFSILREVV 255

  Fly   228 KF---------------------GRNVKRTSVEETR----------FFLLHLGLLREYLELEFDA 261
            ..                     |:..||....:.:          :..||:.:||||||||. .
plant   256 YTPGQQERCFLCGQMGHFASNCEGKPKKRAGESDEKGDGNDFVKKPYQFLHIWVLREYLELEM-R 319

  Fly   262 LRTDEHKLDIAQLIDDWVLMGFLVGNDFIPHLPCLHISSNALPLLYRTYIGIYPTLGGNINENGK 326
            :.....::|:.:::||::.:.|.|||||:||:|.|.|...|:.||...|...:.:..|.:.:..|
plant   320 IPNPPFEIDLERIVDDFIFICFFVGNDFLPHMPTLEIREGAINLLMAVYKKEFRSFDGYLTDGCK 384

  Fly   327 LNLRRLQIFISALTEVELDHFKEHA----------------DDLKYMNNKSEAFDMDV------- 368
            .||:|::.||.|:...|...|::.|                ...|.|::::.....|:
plant   385 PNLKRVEQFIQAVGSFEDKIFQKRAMQHQRQAERVKRDKAGKATKRMDDEAPTVQPDLVPVARFS 449

  Fly   369 -----------------GEITESQNL-----DSDLGALI-------------NKSML------LY 392
                             |.....|.:     .|.:||.|             ||..|      |.
plant   450 GSRLASAPTPSPFQSNDGRSAPHQKVRRLSPGSSVGAAIVDVENSLESDERENKEELKTKLKELI 514

  Fly   393 DDDSE---EDCSDENAVLLKEFQNYKRNFYRNKFK---RDPNDELIEELCHHYVNALQWVLDYYY 451
            .:.|:   .|.::|:.|.|.: ..::..:|..||.   .:..:.:.:::...|...|.||:.||.
plant   515 REKSDAFNSDTTEEDKVKLGQ-PGWRERYYEEKFSVVTPEEMERVRKDVVLKYTEGLCWVMHYYM 578

  Fly   452 RGVQSWDWYYPFHYTPFISDLKNIEQVEIAFHMGTPFLPFQQLLAVLPAASAKLLPVAYHDLMLL 516
            .||.||.|:||:||.||.||||::.:::|.|.:||||.||.|||.|.||||:..||..|..||..
plant   579 EGVCSWQWFYPYHYAPFASDLKDLGEMDIKFELGTPFKPFNQLLGVFPAASSHALPERYRTLMTD 643

  Fly   517 PTSPLAEFYPLEFESDLNGKKHDWEAVVLIPFIDEGRLLAAMLPCEAQLSLEERERNRHGPMYVY 581
            |.||:.:|||.:||.|:|||:..|:.:..:|||||.|||.|:...|..|:.||:.||.
plant   644 PNSPIIDFYPTDFEVDMNGKRFSWQGIAKLPFIDERRLLEAVSEVEFTLTDEEKRRNS------- 701

  Fly   582 KYSTVAQGPMPAYPPLRALPVLYCTEVAKWSHEIAVNLPYSV---CIELPNAARTVFFPGFPTMQ 643
                            |...:|:...    ||.:| .|.:|:   |.:|....|..|
plant   702 ----------------RMCDMLFIAT----SHRLA-ELVFSLDNHCRQLSARERVDF-------- 737

  Fly   644 HLPFDFELRNDRVKVFEQVSRNQNIVLKPRKRQ------------LEDTLT 682
                       :||:..::|...|..|.|...:            :||.||
plant   738 -----------KVKIKPKLSDGMNGYLTPCSGETHPPVFRSPMEGMEDILT 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pcm	NP_001162796.1	XRN1	1..843	CDD:227382	280/831 (34%)
pcm	NP_001162796.1	XRN_N	1..225	CDD:281193	123/256 (48%)
XRN3	NP_565114.1	XRN1	1..823	CDD:227382	280/831 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5049
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D685597at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100417
Panther	1	1.100	-	-	LDO	PTHR12341
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820