DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pcm and XRN4

DIOPT Version :9

Sequence 1:	NP_001162796.1	Gene:	pcm / 32935	FlyBaseID:	FBgn0020261	Length:	1613	Species:	Drosophila melanogaster
Sequence 2:	NP_175851.1	Gene:	XRN4 / 841891	AraportID:	AT1G54490	Length:	947	Species:	Arabidopsis thaliana

Alignment Length:	802	Identity:	278/802 - (34%)
Similarity:	411/802 - (51%)	Gaps:	143/802 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVPKFFRYISERYP-CLSELAREH--------CIP-----------EFDNLYLDMNGIVHNCSH 45
            ||||.|:|::::||| .:|::..|.        .||           ||||||||||||:|.|.|
plant     1 MGVPAFYRWLADRYPKSISDVVEEEPTDGGRGDLIPVDITRPNPNGFEFDNLYLDMNGIIHPCFH 65

  Fly    46 PDDNNIHFHLEEEQIFQEIFNYVDKLFYLIKPQRLFFLSVDGVAPRAKMNQQRSRRFRTAREAEQ 110
            |:........::  :|:.:|.|:|.||.|::|:::.:|::||||||||||||||||||.|::|.:
plant    66 PEGKPAPATYDD--VFKSMFEYIDHLFTLVRPRKILYLAIDGVAPRAKMNQQRSRRFRAAKDAAE 128

  Fly   111 QEAKAAQ-------RGEL----REHERFDSNCITPGTEFMVRLQEGLRAFLKTKISTDPLWQRCT 164
            .||:..:       .|::    .:.|..|||.|||||.||..|...|:.:::::::.:|.|:...
plant   129 AEAEEERLRKDFEMEGQILSAKEKAETCDSNVITPGTPFMAILSVALQYYIQSRLNHNPGWRYVK 193

  Fly   165 VILSGQEAPGEGEHKIMDYIRYMKTQPDYDPNTRHCLYGLDADLIILGLCTHELHFVVLREEV-- 227
            ||||....|||||||||.|||..:..|.:||||||||||||||||:|.|.|||:||.:|||.:
plant   194 VILSDSNVPGEGEHKIMSYIRLQRNLPGFDPNTRHCLYGLDADLIMLSLATHEVHFSILREVITY 258

  Fly   228 ----------------------KFGRN--VKRTSVEETRFFLLHLGLLREYLELEFDALRTDEHK 268
                                  |.|.|  .....:.:.::..|::.:|||||:.|. |:......
plant   259 PGQQEKCFVCGQTGHFASDCPGKSGSNNAAADIPIHKKKYQFLNIWVLREYLQYEL-AIPDPPFM 322

  Fly   269 LDIAQLIDDWVLMGFLVGNDFIPHLPCLHISSNALPLLYRTYIGIYPTLGGNINENGKLNLRRLQ 333
            ::..::|||:|.:.|.|||||:||:|.|.|...|:.||...|...:..:||.:.::|::.|.|::
plant   323 INFERIIDDFVFLCFFVGNDFLPHMPTLEIREGAINLLMHVYRKEFTAMGGYLTDSGEVLLDRVE 387

  Fly   334 IFISALTEVELDHFKEHADDLKYMNNKSEAFDMDVGEITESQNLDSDLGALINKSMLLYDDDSEE 398
            .||.|:...|...|::.....:.|:|..|                             ....|..
plant   388 HFIQAVAVNEDKIFQKRTRIKQSMDNNEE-----------------------------MKQRSRR 423

  Fly   399 DCSD------ENAVLLKEFQNYKRNFYRNKFKR---DPNDELIEELCHHYVNALQWVLDYYYRGV 454
            |.|:      ::.:.|.| ..||..:|..||..   :..:::.:::...||..|.||..|||:||
plant   424 DPSEVPPEPIDDKIKLGE-PGYKERYYAEKFSTTNPEETEQIKQDMVLKYVEGLCWVCRYYYQGV 487

  Fly   455 QSWDWYYPFHYTPFISDLKNIEQVEIAFHMGTPFLPFQQLLAVLPAASAKLLPVAYHDLMLLPTS 519
            .||.|:||:||.||.|||||:..:||.|.:|.||.||.||:..|||||:..||..|..||..|:|
plant   488 CSWQWFYPYHYAPFASDLKNLPDLEITFFIGEPFKPFDQLMGTLPAASSNALPGEYRKLMTDPSS 552

  Fly   520 PLAEFYPLEFESDLNGKKHDWEAVVLIPFIDEGRLLAAMLPCEAQLSLEERERN--RHGPMYVYK 582
            |:.:|||.:||.|:|||:..|:.:..:|||:|..||||....|..|::||::||  ....:||:.
plant   553 PILKFYPADFELDMNGKRFAWQGIAKLPFIEEKLLLAATRKLEETLTVEEQQRNSVMLDLLYVHP 617

  Fly   583 YSTVAQGPMPAY------PPLRALPVLYCTEVAK------WSHE-----IAVNLPYS--VCIELP 628
            ...:.|..:..|      ||...||.:.....::      |..|     ..|:.|.:  .|||..
plant   618 AHPLGQRILQYYHFYQHMPPHECLPWMIDPNSSQGMNGFLWFSERNGFQTRVDSPVNGLPCIEQN 682

  Fly   629 NAARTVFF----------PGFPTMQHLPFDFELRNDRVKVFEQVSRNQNIVLKPRKRQLED---T 680
            .|....:.          |  |....:| |..|.:..:|.|..:....|   ..|:||..|   .
plant   683 RALNVTYLCPAKHSHISEP--PRGAIIP-DKILTSVDIKPFPPLWHEDN---SNRRRQARDRPQV 741

  Fly   681 LTAVASQYLGKVIHVGWPHLVK 702
            :.|:|...||:..|    .|:|
plant   742 VGAIAGPSLGEAAH----RLIK 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pcm	NP_001162796.1	XRN1	1..843	CDD:227382	278/802 (35%)
pcm	NP_001162796.1	XRN_N	1..225	CDD:281193	117/254 (46%)
XRN4	NP_175851.1	XRN1	1..849	CDD:227382	278/802 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	65	1.000	Domainoid score	I3637
eggNOG	1	0.900	-	-		E1_COG5049
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D685597at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100417
Panther	1	1.100	-	-	O	PTHR12341
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820