DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pcm and xrn1

DIOPT Version :9

Sequence 1:	NP_001162796.1	Gene:	pcm / 32935	FlyBaseID:	FBgn0020261	Length:	1613	Species:	Drosophila melanogaster
Sequence 2:	XP_002937144.2	Gene:	xrn1 / 733797	XenbaseID:	XB-GENE-1012713	Length:	1740	Species:	Xenopus tropicalis

Alignment Length:	1812	Identity:	597/1812 - (32%)
Similarity:	896/1812 - (49%)	Gaps:	331/1812 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVPKFFRYISERYPCLSELAREHCIPEFDNLYLDMNGIVHNCSHPDDNNIHFHLEEEQIFQEIF 65
            ||||||:|:||||||||||:.:||.||||||||||||||:|.||||:|:::||.:.|::||.:||
Frog     1 MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRITEDKIFADIF 65

  Fly    66 NYVDKLFYLIKPQRLFFLSVDGVAPRAKMNQQRSRRFRTAREAEQQEAKAAQRGELREHE-RFDS 129
            :|::.||.:|||:::||::||||||||||||||.||||:|:|||.:..||.::||:...| ||||
Frog    66 HYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAVEKGEVLPTEARFDS 130

  Fly   130 NCITPGTEFMVRLQEGLRAFLKTKISTDPLWQRCTVILSGQEAPGEGEHKIMDYIRYMKTQPDYD 194
            ||||||||||.||.|.|:.|:..|||||..||...:.|||.|.|||||||||::||..||:||:|
Frog   131 NCITPGTEFMARLHEHLKYFVNMKISTDKSWQGVAIYLSGHETPGEGEHKIMEFIRSQKTKPDHD 195

  Fly   195 PNTRHCLYGLDADLIILGLCTHELHFVVLREEVKFG--RNVKR-TSVEETRFFLLHLGLLREYLE 256
            |||||||||||||||:|||.:||:||.:|||||:||  :|.|| |:.|||.|.||||.|:|||::
Frog   196 PNTRHCLYGLDADLIMLGLTSHEVHFSLLREEVRFGGKKNQKRVTAPEETTFHLLHLSLMREYID 260

  Fly   257 LEFDALRTD-EHKLDIAQLIDDWVLMGFLVGNDFIPHLPCLHISSNALPLLYRTYIGIYPTLGGN 320
            .||.:|:.. ..:.|:.::||||:|||||||||||||||.|||:.:||||||||||.:.||:||.
Frog   261 YEFSSLKNKISFEYDVERIIDDWILMGFLVGNDFIPHLPHLHINHDALPLLYRTYISVLPTIGGY 325

  Fly   321 INENGKLNLRRLQIFISALTEVELDHFKEHADDLKYMNNK--SEAFDMDVGEIT-ESQNLDSD-- 380
            |||||.|||.....::..|::.:.:||.|...|||:..:|  ::..:...|:.. |::|:...
Frog   326 INENGYLNLYNFGKYLEKLSDFDREHFNEIFVDLKWFESKVGNKYLNEAAGQAAEEAKNIKKKKN 390

  Fly   381 --------LGALIN---KSMLLYDDDSEEDCSDENAVLLKEFQNYKRNFYRNKFKRD-PNDELIE 433
                    ..||.|   ::....|:|.|:| .:|:.:...||:.|||.:|.:|...: .:||.:.
Frog   391 KVPEDAFCFSALENNGEENSECLDEDPEDD-ENEDDLFETEFRQYKRTYYMSKMGVEVVSDEFLA 454

  Fly   434 ELCHHYVNALQWVLDYYYRGVQSWDWYYPFHYTPFISDLKNIEQVEIAFHMGTPFLPFQQLLAVL 498
            :....||.|:||:|.|||.|||||.||||:||.|::||:.||..:::.|::|.||:||:||||||
Frog   455 DQAKCYVQAIQWILHYYYHGVQSWSWYYPYHYAPYLSDICNISHLKLTFNLGKPFMPFEQLLAVL 519

  Fly   499 PAASAKLLPVAYHDLMLLPTSPLAEFYPLEFESDLNGKKHDWEAVVLIPFIDEGRLLAAMLPCEA 563
            ||||..|||:.|.:||:...||:.::||.:|::|||||:.:||||||||||||.|||.||:.|..
Frog   520 PAASKDLLPLTYQNLMISSDSPIIDYYPQDFKTDLNGKQQEWEAVVLIPFIDEKRLLEAMVSCNR 584

  Fly   564 QLSLEERERNRHGPMYVYKYSTVAQ----GPMP-AYPPLRALPVLY-CTEVAKWSHEIAVNLPYS 622
            .|:.||::||:|.....|.|.....    .|.| .:|.:......| ...:..|..::..|....
Frog   585 SLAEEEKKRNQHSECIKYWYEKETDFKYFSPWPEKFPSVDRCHARYKLISLDAWLVDVTDNKITK 649

  Fly   623 VCIELPNAARTVFFPGFPTMQHLPFDFELRNDRVKVFEQVSRNQNIVLKPRKRQLEDTLT--AVA 685
            |      ....::|.||||::|:...:.::...|:||:|.||.:|::|:......||||.  .||
Frog   650 V------DKSALYFCGFPTLKHIKHKYSMKKAGVQVFQQSSRGENMILEIETEGDEDTLNVDTVA 708

  Fly   686 SQYLGKVIHVGWPHLVKAIVVRVATRDQRV------------------DSEGITLNDSRR--FDS 730
            |..|||.:.|.||||.:|.||.|...|.:.                  .::...:.|..|  :..
Frog   709 SAVLGKSVFVNWPHLEEARVVTVTDGDMKFYLEERPGTQKLYTGNSVPPTKVAYVGDKERNIWVK 773

  Fly   731 ECKALQEHFINRMGIQFANYDVLVYVRTFAGNSTEFRDKGALMVRDSWSSSVTGYPAQGVVADLT 795
            |.:.:.||:..|.|:......|::|.:...|...:....|.:.:...||..|..:..|.||.|:|
Frog   774 EIQGISEHYHRRKGVVINETAVVLYAQLLTGRRYQLGHNGEVHLEKQWSKQVLPFVYQAVVQDIT 838

  Fly   796 VWERMRKNFLNVEHYFPVGSTIFLITDPYYGSEGTVQDPRLAYTNGRIQVSIMVRPEPKVNAARQ 860
            .:|....::..:...|...|::|::..||||..|.||:.....:..||:|.:.:..||:::|..|
Frog   839 TFESGSSHYKTLGELFSPESSVFMLGAPYYGCIGEVQESSDVLSENRIRVLLTIPCEPQLDALIQ 903

  Fly   861 LQEERDRDYLSTFQVCNLLRISGRTLGRLSGTVWVVLGPRRQKMENVTKHNIGLQLKYPRQNEER 925
            .|.:....|...:.:.:.|.::|..:.|.:|::::..|.::.. ....|.|:||.||:.::|||.
Frog   904 NQHKFSIKYNPGYVLASRLGVNGYLVSRFTGSIFIGRGSKKNP-HGEQKSNVGLNLKFNKKNEEV 967

  Fly   926 AGYCFRTNNQWYYSSLAVDLMRNYCQRYPDVIDFFGDSNDRAEFVFEQDVFP--NAVGHRRVEEL 988
            .||..|...:|.|||.|..|:..|.:|:|::. .:.....:.:..:|.|::|  |..|..:|:|:
Frog   968 PGYTKRVGTEWTYSSAAEVLLSEYIERFPELF-LYVSKKSQEDVFYEDDIWPGENENGAEKVQEI 1031

  Fly   989 ANWVRQQPHMKVERISCGSKTVCRETIELLIAAVDDLRSLPVKHVKLQVKPHLLIKP----NVTL 1049
            .:|::..|...:.|.||..:.:....:|.:...|:..:|.....|::.||||||.||    :..:
Frog  1032 VSWLKSHPVNMLSRSSCDLQILDAAIVEKIEEEVEKCKSKKNSKVRVTVKPHLLFKPLEQQHGVV 1096

  Fly  1050 PDVYRSKRPVRLFDRVVIVRTIYMVPVGTKGTVIGIHPVTDPNPVRLECVHAVDTFCKVLFDSPV 1114
            ||   .....||:||||.||..:.||:|.:||||||........|.||          ||||...
Frog  1097 PD---PDAEFRLYDRVVNVRENFSVPLGLRGTVIGIKGAERDADVLLE----------VLFDEVF 1148

  Fly  1115 P-----NCNNIHGIAEDRVYKVPEIALVII----KTDEEGKKQNDCELPVRDPQP---NQAQDE- 1166
            |     .|:...|      |::|..||:.:    :.:..|:|..    .|..|||   :...|:
Frog  1149 PGGLTIRCSQFKG------YRLPTSALINLSHGNRMESGGQKLT----AVVKPQPAINHHVSDKE 1203

  Fly  1167 --------------PVRATSSRYVTAAGSTSVP---------ITMKTQISDEFVK-------TRS 1201
                          |.:....::  :.|..:.|         ...|.:..||:..       :..
Frog  1204 QMGGLNHSPRSLFVPTKVNGKQH--SQGQANSPHKGFASAGNQKQKHKQDDEYYNVWHSLQDSGK 1266

  Fly  1202 DPIARTDSYKPSS---EPKPVP--------VPEQITNWRERVSTPTNKPQPAPNNWRINRSSSRQ 1255
            .|.|:....|..:   |.||.|        :.|.....:.:...|..|.:   .::|..:..|:.
Frog  1267 SPRAQNLHGKAMNLPQEKKPGPNNHFYKSEMAESSPKCQSKRQDPIRKMK---EDFRFQKHESQT 1328

  Fly  1256 QG------------------------------------------------GSIFVAPPTKTPDAA 1272
            ||                                                .|:.:|...:|..|.
Frog  1329 QGALNKPNTYDSMKQVKLLKRTDNLLDMQIEKDIPKASEGKPNSEFENLIASLKIADEEQTQPAP 1393

  Fly  1273 ASTASTAFTAASSATLTP----LDQTLALMSVLGVGEDQSSPPLQEAVQQQRPPLLQQQR----- 1328
            .|...    ::|:..|:|    :..|..|..:|.:....|:...:|.|::.......|::
Frog  1394 QSQDK----SSSAEHLSPQSFAMKGTQMLKEILKIDSSDSTDQHKEGVKKDTVTASSQRKQTKQI 1454

  Fly  1329 ---------------APFPGQM--PNLPKPPLF----------------------WQQEAQKQEA 1354
                           ||.|..:  |.:|:||..                      :.:.||...|
Frog  1455 AAHMNRPQGAGAAFSAPNPESLRAPLIPQPPAMGTPLSELYRICSLVGMHPPEFSFLRTAQALTA 1519

  Fly  1355 LQQEAQQQ--------EAQKKQQQAHAQMEPERINSQHFYRSGQTGAALNQPPLGAPSKRQWHEW 1411
            .|.:....        .|:.:.::..|....:|::|..|        .|..||...|:      :
Frog  1520 CQVKLSNGLIIAGPPCHAENEAKEKAALFALQRLSSISF--------PLPPPPAMFPT------Y 1570

  Fly  1412 VH-----PRMQHANAFHAGVNNGYQMRPKKNIAAQSTFNNNVHMHLQQPYYPNQQQQQQQQQPLQ 1471
            .|     |..|..:.|.....|.....|  ::.|..|:...:  .:.:||||.         |..
Frog  1571 PHLGAALPAGQMPSVFPPAAANMIPAAP--HVFAPVTWRPQI--QIPKPYYPG---------PFP 1622

  Fly  1472 LTEINNAP-----PRYSTIQDFVPIQAYRPKKLNRVQPAGRQDVDATKNPSRSPVLQQPTNETID 1531
                :|||     |..|..| |||:|..:.:.........::.|    |||::
Frog  1623 ----SNAPVVGHMPAGSHNQ-FVPLQVTKQRAAFHKNSEYKEPV----NPSQT------------ 1666

  Fly  1532 TKASSSLPVQSAGEQVIGLMQTLEIKQPAASQSESDGVSTGSANAPTA-TTSSQAVN 1587
                     .|..||        .:....:|||..|..|...|:..|| .||::.|:
Frog  1667 ---------SSDHEQ--------RLVPDGSSQSPQDTASPSLASHQTAQPTSAEKVS 1706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pcm	NP_001162796.1	XRN1	1..843	CDD:227382	402/891 (45%)
pcm	NP_001162796.1	XRN_N	1..225	CDD:281193	150/224 (67%)
xrn1	XP_002937144.2	XRN1	1..734	CDD:227382	371/739 (50%)
		XRN1_D2_D3	856..935	CDD:375761	21/78 (27%)
		SH3_12	1101..1171	CDD:380117	31/85 (36%)
		PHA03247	<1460..1699	CDD:223021	58/303 (19%)
		Med26_M	<1620..1740	CDD:374027	29/125 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5894
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54191
OrthoDB	1	1.010	-	-		D150649at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12341
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030