DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pcm and dhp1

DIOPT Version :9

Sequence 1:	NP_001162796.1	Gene:	pcm / 32935	FlyBaseID:	FBgn0020261	Length:	1613	Species:	Drosophila melanogaster
Sequence 2:	NP_594155.1	Gene:	dhp1 / 2542674	PomBaseID:	SPAC26A3.12c	Length:	991	Species:	Schizosaccharomyces pombe

Alignment Length:	1006	Identity:	318/1006 - (31%)
Similarity:	453/1006 - (45%)	Gaps:	280/1006 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVPKFFRYIS---------------ERYPCLSELAREHCIP-----EFDNLYLDMNGIVHNCSH 45
            ||||..||.:|               |:.|..:|:..:..:|     |.||||||||||||.|||
pombe     1 MGVPALFRLLSRKFAKVITPVIEAPTEKLPDGTEIEPDLSLPNPNGVECDNLYLDMNGIVHPCSH 65

  Fly    46 PDDNNIHFHLEEEQIFQEIFNYVDKLFYLIKPQRLFFLSVDGVAPRAKMNQQRSRRFRTAREAEQ 110
            |:|...  ...|:::...:|.|.|::..:::|::|.|:::||||||||||||||||||::|||..
pombe    66 PEDRPA--PETEDEMMVAVFEYTDRILAMVRPRQLLFIAIDGVAPRAKMNQQRSRRFRSSREAAL 128

  Fly   111 QE-------AKAAQRG-----ELREHERFDSNCITPGTEFMVRLQEGLRAFLKTKISTDPLWQRC 163
            :|       .:|.|:|     ...:.:.:|||||||||.||..|.:.||.::..|:::||.|:..
pombe   129 KEEELQAFIEEAKQQGIPIDENATKKKSWDSNCITPGTPFMDTLAKSLRYYIINKLNSDPCWRNV 193

  Fly   164 TVILSGQEAPGEGEHKIMDYIRYMKTQPDYDPNTRHCLYGLDADLIILGLCTHELHFVVLREEVK 228
            ..|||....|||||||||::||..:.:|:|||||.|.:||||||||:|||.|||.||.||||:|.
pombe   194 RFILSDASVPGEGEHKIMEFIRSQRVKPEYDPNTHHVVYGLDADLIMLGLATHEPHFRVLREDVF 258

  Fly   229 FGR-NVKRT-----------SVEETR-------FFLLHLGLLREYLELEFDALRTDEHKLDIAQL 274
            |.: :.|:|           .|.||.       |..|::.:||||||:|. .:.......|:.:.
pombe   259 FQQGSTKKTKEERLGIKRLDDVSETNKVPVKKPFIWLNVSILREYLEVEL-YVPNLPFPFDLERA 322

  Fly   275 IDDWVLMGFLVGNDFIPHLPCLHISSNALPLLYRTYIGIYPTLGGNINENGKLNLRRLQIFISAL 339
            |||||...|.|||||:||||.|.|...|:..|...:....|.:||.:..:|.:||.|.::.:||:
pombe   323 IDDWVFFIFFVGNDFLPHLPSLDIRDGAVERLTEIWRASLPHMGGYLTLDGSVNLARAEVILSAV 387

  Fly   340 TEVELDHFK--------------------EHADDLKYMNN----------------KSEAFDMDV 368
            ...|.|.||                    .:.:...|::|                .|::..:|.
pombe   388 GNQEDDIFKRLKQQEDRRNENYRRRQQRESNQESESYVDNVVIQRSVETQSTEVVTSSKSTSVDT 452

  Fly   369 GEITESQNLDS----------------DLGA----LIN--------------------------- 386
            ....::|.:|:                .|||    |||
pombe   453 KPPKKTQKIDAPAPVDLVNLSEKTSNRSLGATNRELINNRAANRLGLSREAAAVSSVNKLAASAL 517

  Fly   387 KSMLL-------------------YDD----------------------------DSEEDCSDEN 404
            |:.|:                   |:|                            ||.|:..:.:
pombe   518 KAQLVSNETLQNVPLEDSIASSSAYEDTDSIESSTPVVHPIDTKVSNVGQKRKAPDSTEENENTD 582

  Fly   405 AVLLKEFQNYKRNFYRNKFKRDPND-ELIEELCHHYVNALQWVLDYYYRGVQSWDWYYPFHYTPF 468
            .|.|.| ..|:..:|..||...|:: |.|.|...|||:.|.|||.|||:|..||.||||:||.||
pombe   583 TVRLYE-PGYRERYYEQKFHISPDEPEKIREAVKHYVHGLCWVLLYYYQGCPSWTWYYPYHYAPF 646

  Fly   469 ISDLKNIEQVEIAFHMGTPFLPFQQLLAVLPAASAKLLPVAYHDLMLLPTSPLAEFYPLEFESDL 533
            .:|.|::..:::.|.:..||.|::|||.||||||...||.....||....|.:.:|||..|..||
pombe   647 AADFKDLASIDVKFELNQPFKPYEQLLGVLPAASKNNLPEKLQTLMTDENSEIIDFYPENFTIDL 711

  Fly   534 NGKKHDWEAVVLIPFIDEGRLLAAMLPCEAQLSLEERERN----------RHGPMY--VYK--YS 584
            ||||.:|:.|.|:|||||.|||.|:.....||:.||.:||          .|.||:  :.|  ||
pombe   712 NGKKFEWQGVALLPFIDENRLLNAVSKIYPQLTEEESKRNEDGSTLLFISEHHPMFSELVKQLYS 776

  Fly   585 TVAQGPMPAYPPLRALPVLYCTEVAKWSHEI--AVNLPYSVCIELPNAARTVFFPGFPTMQHLPF 647
            ...||     .||:.        ..|.:|.:  .||...||   :||.:           ...|.
pombe   777 KKRQG-----KPLKL--------SGKMAHGLFGKVNTNDSV---IPNVS-----------VQCPI 814

  Fly   648 DFELRNDRVKVFEQVSRNQNIVLKPRKRQLEDTLTAVASQYLGKVIHVGWPHLV-KAIVVRVATR 711
            |. ...|.::.:..:..||:|.|                     |..|...|.| |::::|....
pombe   815 DV-TSADALQKYGSIDDNQSISL---------------------VFEVPKSHFVHKSMLLRGVKM 857

  Fly   712 DQRVDSEGITLND------SRRFDS------ECKALQEHFINRMGIQFANYDVLVYVRTFAGNST 764
            ..||    :|..|      .|.|.|      ..:...:.:..|...|..:|...   :::.|.:.
pombe   858 PNRV----LTPEDINQVRAERSFSSRRNNGNSYRGGHQSYGVRRSYQSQSYSSR---QSYTGVTN 915

  Fly   765 EFRDKGALMVRDSWSS------SVTGYPAQG 789
            .|.:.|   |:..||.      |...|.::|
pombe   916 GFANGG---VQPPWSGNGNFPRSNASYNSRG 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pcm	NP_001162796.1	XRN1	1..843	CDD:227382	318/1006 (32%)
pcm	NP_001162796.1	XRN_N	1..225	CDD:281193	118/255 (46%)
dhp1	NP_594155.1	XRN1	1..981	CDD:227382	318/1006 (32%)
dhp1	NP_594155.1	XRN_N	1..255	CDD:281193	118/255 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5049
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100417
Panther	1	1.100	-	-	O	PTHR12341
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810