DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pcm and exo2

DIOPT Version :9

Sequence 1:	NP_001162796.1	Gene:	pcm / 32935	FlyBaseID:	FBgn0020261	Length:	1613	Species:	Drosophila melanogaster
Sequence 2:	NP_593482.1	Gene:	exo2 / 2542204	PomBaseID:	SPAC17A5.14	Length:	1328	Species:	Schizosaccharomyces pombe

Alignment Length:	1405	Identity:	468/1405 - (33%)
Similarity:	691/1405 - (49%)	Gaps:	266/1405 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVPKFFRYISERYPCLSELAREHCIPEFDNLYLDMNGIVHNCSHPDDNNIHFHLEEEQIFQEIF 65
            ||:|||||::|||||..|:|.....||||||||||||||:|||:|.:|::....|.||:::..||
pombe     1 MGIPKFFRWMSERYPLCSQLIENDRIPEFDNLYLDMNGILHNCTHKNDDHSSPPLPEEEMYIAIF 65

  Fly    66 NYVDKLFYLIKPQRLFFLSVDGVAPRAKMNQQRSRRFRTAREAEQQEAKAAQRGELREHERFDSN 130
            ||::.||..|||::|.:::|||.|||||||||||||||||::|.....||.:.||....|:||||
pombe    66 NYIEHLFEKIKPKKLLYMAVDGCAPRAKMNQQRSRRFRTAKDAHDARLKAERNGEDFPEEQFDSN 130

  Fly   131 CITPGTEFMVRLQEGLRAFLKTKISTDPLWQRCTVILSGQEAPGEGEHKIMDYIRYMKTQPDYDP 195
            ||||||.||.|:...|..|:..|::.|..||...||.||.:.|||||||||:|||..|.||.|:|
pombe   131 CITPGTTFMERVSRQLYYFIHKKVTNDSQWQNIEVIFSGHDCPGEGEHKIMEYIRTQKAQPSYNP 195

  Fly   196 NTRHCLYGLDADLIILGLCTHELHFVVLREEVKFGRNVKRTSVE--ETRFFLLHLGLLREYLELE 258
            ||||||||||||||:|||.:|:.||.:|||||.||...:..|.|  ..:|:||||.|||||||.|
pombe   196 NTRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGPASRNRSKELAHQKFYLLHLSLLREYLEFE 260

  Fly   259 FDALR-TDEHKLDIAQLIDDWVLMGFLVGNDFIPHLPCLHISSNALPLLYRTYIGIYPTLGGNIN 322
            |...| |...|.|:.:::||::|:.|.|||||:||||.|||:..||.|::..|..:.|:.||.||
pombe   261 FQECRSTFTFKYDLEKILDDFILLAFFVGNDFLPHLPGLHINEGALALMFSIYKKVMPSAGGYIN 325

  Fly   323 ENGKLNLRRLQIFISALTEVELDHFK------------------------EHADDLKYMNNKSEA 363
            |.|.:|:.||::.:..|...|.:.||                        |..:|:|.|..:.:.
pombe   326 EKGVINMARLELILLELENFEKEIFKAEVSETKNNGNSDKPSFDFLKYITESTNDIKAMTGEQKN 390

  Fly   364 FDMDVGEITESQNLDSDLGALIN----------------------------------KSMLLYDD 394
            :.:.:.:...|:....|..|.|:                                  :.:...|:
pombe   391 YFLQIKKFLSSREPFIDFSANISSVDQRFLRRLCNDLHLSFSKIIKVDGTHLLRITFRDLEFNDE 455

  Fly   395 DSEEDCSDE---------NAVLL------------KEFQNYKRNFYRNKFKRDPND-ELIEELCH 437
            |.:|...||         |..||            |:|..:|.::||:|......| |.::.:..
pombe   456 DEDEIEQDEIERVLQKYDNIPLLNEEQALKEKNVEKDFIQWKDDYYRSKVGFSYYDEEALKAMAE 520

  Fly   438 HYVNALQWVLDYYYRGVQSWDWYYPFHYTPFISD-LKNIEQVEIAFHMGTPFLPFQQLLAVLPAA 501
            .||..|||||.|||||.|||.|||.:|:.|.||| ||.:: |:|.|.|||||.||:||:|||||.
pombe   521 RYVEGLQWVLFYYYRGCQSWGWYYNYHFAPKISDVLKGLD-VKIDFKMGTPFRPFEQLMAVLPAR 584

  Fly   502 SAKLLPVAYHDLMLLPTSPLAEFYPLEFESDLNGKKHDWEAVVLIPFIDEGRLLAAMLPCEAQLS 566
            |..|:|..:.|||:...||:.:|||..|..|.|||...|||||:||||||.||:.|:...:..|:
pombe   585 SQALVPPCFRDLMVNSESPIIDFYPENFALDQNGKTASWEAVVIIPFIDETRLIDALASKDKFLT 649

  Fly   567 LEERERNRHGPMYVYKYSTVAQGPMPAYPPLRALPVLYCTEVAKWSHEIAVNLPYSVCIELPN-- 629
            .|||:||......|:   ::|:.....||  .:||.|:...|.:     .:..|||    ||:
pombe   650 EEERKRNSFNAPTVF---SLAEDYTSFYP--SSLPSLFPDLVTR-----CIQKPYS----LPSME 700

  Fly   630 ---------------AARTVFFPGFPTMQHLPFDFELRNDRVKVFEQVSRNQNIVLKPRKRQLED 679
                           |...|.||.|.|::|   ..||....:.||...|||.::::     .:||
pombe   701 GKEYLVGLCPGVFLGAFGMVGFPSFHTLKH---KAELVYHGINVFGNESRNPSVIV-----NVED 757

  Fly   680 TLTA-----VASQYLGKVIHVGWPHLVKAIV-------VRVATRDQRVDSEGITLNDSRRFDSEC 732
            ..:|     :|.||:||.|.|.||:|.:|.|       ......:..::...:...:..::..:|
pombe   758 VKSALTSEQIAMQYVGKRIFVDWPYLREAYVESAMDESYMYLASNSTIEKRDLAEIEKSQWGRKC 822

  Fly   733 KALQEHFINRMGIQFANYDVLVYVRTFAGNSTEFRDKGALMVRDSWSSSVTGYPAQGVVADLTVW 797
            ......:..|.|:.|.:..:|:.||...|  .|:..:||| |:....|.:..||||.||..:.:.
pombe   823 SHKIREYSKRFGVLFGDISLLLQVRPIKG--LEYTREGAL-VKIFNESVLEDYPAQLVVEKIAID 884

  Fly   798 ER--MRKNFLNVEHYFPVGSTIFLITDPYYGSEGTV---QDPRLAYTNGRIQVSIMVRPEPKVNA 857
            :.  ..:....||..:|.|:..|.:.:..||....:   :|.:|.         |.:...|.::|
pombe   885 DPRFTEREAPPVEVEYPPGTKAFHLGEYNYGRPAQITGCKDNKLI---------IWLSTAPGLDA 940

  Fly   858 --ARQL-QEERDRD-YLSTFQVCNLLRISGRTLGRLSGTVWVVLGPRRQKMENVTKHNIGLQLKY 918
              .|.| .:.:.:: |..::.|..||.|....|.:::.:..:..|.:|:        ||||.||:
pombe   941 QWGRVLVNDSKSKEKYYPSYIVAKLLNIHPLLLSKITSSFLISNGTKRE--------NIGLNLKF 997

  Fly   919 PRQNEERAGYCFRTNNQWYYSSLAVDLMRNYCQRYPDVIDFFGDSNDRAEFVFEQDVFPN----- 978
            ..:|::..|:..::...|.:|:..|.|::.|...:|.:.:.. .::...:.:..:|.||.
pombe   998 DARNQKVLGFSRKSTKGWEFSNKTVALVKEYINTFPQLFNIL-TTHATKDNLTVKDCFPKDDTQQ 1061

  Fly   979 --AVGHRRVEELANWVRQQPHMKVERISCGSKTVCRETIELL---IAAVDDLRSLPVKHVKLQVK 1038
              ||.|        |::::....:.|:|.....:..:.|:|:   .:.:|....:|.|  ...|.
pombe  1062 LAAVKH--------WIKEKGINSLTRVSLDEDALDSDIIKLIEEKASTIDSTYQVPKK--VFGVP 1116

  Fly  1039 PHLLIKPNVTLPDVYRSKRPVRLFDRVVIVRTIYMVPVGTKGTVIGIHPVTDPNPVRLECVHAVD 1103
            .:.|:||:.|...::  .:...|.||||.|:....||:...|||:||            .:|.:|
pombe  1117 RYALLKPSQTRGILH--SQEFALGDRVVYVQDSGKVPIAAYGTVVGI------------MLHHLD 1167

  Fly  1104 TFCKVLFDSPVPN-------CNNIHGIAEDRVYKVPEIALVIIKTDEEGKKQNDCELPVRDPQPN 1161
                |:||.|..:       |:..||:.       .|:::|               |.|.:||
pombe  1168 ----VVFDLPFMSGTTLDGRCSPYHGMQ-------VEVSMV---------------LNVTNPQ-- 1204

  Fly  1162 QAQDEPVRATSSRYV--TAAGSTSVPITMKTQISDEFVKTRSDPIARTDSYKPSSE-PKPVPVPE 1223
                         :|  |.||.     ..||.:|...|...:|....|   ||:|. |.| |.|.
pombe  1205 -------------FVVNTRAGK-----NRKTNVSANNVSQGTDSRLVT---KPTSTFPSP-PSPP 1247

  Fly  1224 QITNWRERVSTPTNKP----QPAPNNWRINRSSSRQQGGS 1259
            ..:.|.:|...|  ||    |..|....|::|.|:...|:
pombe  1248 SSSVWNKREHHP--KPFSLHQVPPPESLIHKSKSKFSKGN 1285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pcm	NP_001162796.1	XRN1	1..843	CDD:227382	366/959 (38%)
pcm	NP_001162796.1	XRN_N	1..225	CDD:281193	133/223 (60%)
exo2	NP_593482.1	XRN1	1..932	CDD:227382	367/965 (38%)
exo2	NP_593482.1	XRN_N	1..225	CDD:281193	133/223 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	290	1.000	Domainoid score	I281
eggNOG	1	0.900	-	-		E1_COG5049
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5894
Inparanoid	1	1.050	611	1.000	Inparanoid score	I154
OMA	1	1.010	-	-		QHG54191
OrthoFinder	1	1.000	-	-		FOG0006565
OrthoInspector	1	1.000	-	-		oto100477
orthoMCL	1	0.900	-	-		OOG6_100417
Panther	1	1.100	-	-	LDO	PTHR12341
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4229
SonicParanoid	1	1.000	-	-		X4804
TreeFam	1	0.960	-	-
	14	13.860