Protein Alignment pcm and exo2

DIOPT Version :10

• Sequence 1: NP_001162796.1
• Gene: pcm / 32935
• FlyBaseID: FBgn0020261
• Length: 1613
• Species: Drosophila melanogaster
• Sequence 2: NP_593482.1
• Gene: exo2 / 2542204
• PomBaseID: SPAC17A5.14
• Length: 1328
• Species: Schizosaccharomyces pombe
• Alignment Length: 1405
• Identity: 468/1405 - (33%)
• Similarity: 691/1405 - (49%)
• Gaps: 266/1405 - (18%)

  Fly     1 MGVPKFFRYISERYPCLSELAREHCIPEFDNLYLDMNGIVHNCSHPDDNNIHFHLEEEQIFQEIF 65
            ||:|||||::|||||..|:|.....||||||||||||||:|||:|.:|::....|.||:::..||
pombe     1 MGIPKFFRWMSERYPLCSQLIENDRIPEFDNLYLDMNGILHNCTHKNDDHSSPPLPEEEMYIAIF 65

  Fly    66 NYVDKLFYLIKPQRLFFLSVDGVAPRAKMNQQRSRRFRTAREAEQQEAKAAQRGELREHERFDSN 130
            ||::.||..|||::|.:::|||.|||||||||||||||||::|.....||.:.||....|:||||
pombe    66 NYIEHLFEKIKPKKLLYMAVDGCAPRAKMNQQRSRRFRTAKDAHDARLKAERNGEDFPEEQFDSN 130

  Fly   131 CITPGTEFMVRLQEGLRAFLKTKISTDPLWQRCTVILSGQEAPGEGEHKIMDYIRYMKTQPDYDP 195
            ||||||.||.|:...|..|:..|::.|..||...||.||.:.|||||||||:|||..|.||.|:|
pombe   131 CITPGTTFMERVSRQLYYFIHKKVTNDSQWQNIEVIFSGHDCPGEGEHKIMEYIRTQKAQPSYNP 195

  Fly   196 NTRHCLYGLDADLIILGLCTHELHFVVLREEVKFGRNVKRTSVE--ETRFFLLHLGLLREYLELE 258
            ||||||||||||||:|||.:|:.||.:|||||.||...:..|.|  ..:|:||||.|||||||.|
pombe   196 NTRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGPASRNRSKELAHQKFYLLHLSLLREYLEFE 260

  Fly   259 FDALR-TDEHKLDIAQLIDDWVLMGFLVGNDFIPHLPCLHISSNALPLLYRTYIGIYPTLGGNIN 322
            |...| |...|.|:.:::||::|:.|.|||||:||||.|||:..||.|::..|..:.|:.||.||
pombe   261 FQECRSTFTFKYDLEKILDDFILLAFFVGNDFLPHLPGLHINEGALALMFSIYKKVMPSAGGYIN 325

  Fly   323 ENGKLNLRRLQIFISALTEVELDHFK------------------------EHADDLKYMNNKSEA 363
            |.|.:|:.||::.:..|...|.:.||                        |..:|:|.|..:.:.
pombe   326 EKGVINMARLELILLELENFEKEIFKAEVSETKNNGNSDKPSFDFLKYITESTNDIKAMTGEQKN 390

  Fly   364 FDMDVGEITESQNLDSDLGALIN----------------------------------KSMLLYDD 394
            :.:.:.:...|:....|..|.|:                                  :.:...|:
pombe   391 YFLQIKKFLSSREPFIDFSANISSVDQRFLRRLCNDLHLSFSKIIKVDGTHLLRITFRDLEFNDE 455

  Fly   395 DSEEDCSDE---------NAVLL------------KEFQNYKRNFYRNKFKRDPND-ELIEELCH 437
            |.:|...||         |..||            |:|..:|.::||:|......| |.::.:..
pombe   456 DEDEIEQDEIERVLQKYDNIPLLNEEQALKEKNVEKDFIQWKDDYYRSKVGFSYYDEEALKAMAE 520

  Fly   438 HYVNALQWVLDYYYRGVQSWDWYYPFHYTPFISD-LKNIEQVEIAFHMGTPFLPFQQLLAVLPAA 501
            .||..|||||.|||||.|||.|||.:|:.|.||| ||.:: |:|.|.|||||.||:||:|||||.
pombe   521 RYVEGLQWVLFYYYRGCQSWGWYYNYHFAPKISDVLKGLD-VKIDFKMGTPFRPFEQLMAVLPAR 584

  Fly   502 SAKLLPVAYHDLMLLPTSPLAEFYPLEFESDLNGKKHDWEAVVLIPFIDEGRLLAAMLPCEAQLS 566
            |..|:|..:.|||:...||:.:|||..|..|.|||...|||||:||||||.||:.|:...:..|:
pombe   585 SQALVPPCFRDLMVNSESPIIDFYPENFALDQNGKTASWEAVVIIPFIDETRLIDALASKDKFLT 649

  Fly   567 LEERERNRHGPMYVYKYSTVAQGPMPAYPPLRALPVLYCTEVAKWSHEIAVNLPYSVCIELPN-- 629
            .|||:||......|:   ::|:.....||  .:||.|:...|.:     .:..|||    ||:
pombe   650 EEERKRNSFNAPTVF---SLAEDYTSFYP--SSLPSLFPDLVTR-----CIQKPYS----LPSME 700

  Fly   630 ---------------AARTVFFPGFPTMQHLPFDFELRNDRVKVFEQVSRNQNIVLKPRKRQLED 679
                           |...|.||.|.|::|   ..||....:.||...|||.::::     .:||
pombe   701 GKEYLVGLCPGVFLGAFGMVGFPSFHTLKH---KAELVYHGINVFGNESRNPSVIV-----NVED 757

  Fly   680 TLTA-----VASQYLGKVIHVGWPHLVKAIV-------VRVATRDQRVDSEGITLNDSRRFDSEC 732
            ..:|     :|.||:||.|.|.||:|.:|.|       ......:..::...:...:..::..:|
pombe   758 VKSALTSEQIAMQYVGKRIFVDWPYLREAYVESAMDESYMYLASNSTIEKRDLAEIEKSQWGRKC 822

  Fly   733 KALQEHFINRMGIQFANYDVLVYVRTFAGNSTEFRDKGALMVRDSWSSSVTGYPAQGVVADLTVW 797
            ......:..|.|:.|.:..:|:.||...|  .|:..:||| |:....|.:..||||.||..:.:.
pombe   823 SHKIREYSKRFGVLFGDISLLLQVRPIKG--LEYTREGAL-VKIFNESVLEDYPAQLVVEKIAID 884

  Fly   798 ER--MRKNFLNVEHYFPVGSTIFLITDPYYGSEGTV---QDPRLAYTNGRIQVSIMVRPEPKVNA 857
            :.  ..:....||..:|.|:..|.:.:..||....:   :|.:|.         |.:...|.::|
pombe   885 DPRFTEREAPPVEVEYPPGTKAFHLGEYNYGRPAQITGCKDNKLI---------IWLSTAPGLDA 940

  Fly   858 --ARQL-QEERDRD-YLSTFQVCNLLRISGRTLGRLSGTVWVVLGPRRQKMENVTKHNIGLQLKY 918
              .|.| .:.:.:: |..::.|..||.|....|.:::.:..:..|.:|:        ||||.||:
pombe   941 QWGRVLVNDSKSKEKYYPSYIVAKLLNIHPLLLSKITSSFLISNGTKRE--------NIGLNLKF 997

  Fly   919 PRQNEERAGYCFRTNNQWYYSSLAVDLMRNYCQRYPDVIDFFGDSNDRAEFVFEQDVFPN----- 978
            ..:|::..|:..::...|.:|:..|.|::.|...:|.:.:.. .::...:.:..:|.||.
pombe   998 DARNQKVLGFSRKSTKGWEFSNKTVALVKEYINTFPQLFNIL-TTHATKDNLTVKDCFPKDDTQQ 1061

  Fly   979 --AVGHRRVEELANWVRQQPHMKVERISCGSKTVCRETIELL---IAAVDDLRSLPVKHVKLQVK 1038
              ||.|        |::::....:.|:|.....:..:.|:|:   .:.:|....:|.|  ...|.
pombe  1062 LAAVKH--------WIKEKGINSLTRVSLDEDALDSDIIKLIEEKASTIDSTYQVPKK--VFGVP 1116

  Fly  1039 PHLLIKPNVTLPDVYRSKRPVRLFDRVVIVRTIYMVPVGTKGTVIGIHPVTDPNPVRLECVHAVD 1103
            .:.|:||:.|...::  .:...|.||||.|:....||:...|||:||            .:|.:|
pombe  1117 RYALLKPSQTRGILH--SQEFALGDRVVYVQDSGKVPIAAYGTVVGI------------MLHHLD 1167

  Fly  1104 TFCKVLFDSPVPN-------CNNIHGIAEDRVYKVPEIALVIIKTDEEGKKQNDCELPVRDPQPN 1161
                |:||.|..:       |:..||:.       .|:::|               |.|.:||
pombe  1168 ----VVFDLPFMSGTTLDGRCSPYHGMQ-------VEVSMV---------------LNVTNPQ-- 1204

  Fly  1162 QAQDEPVRATSSRYV--TAAGSTSVPITMKTQISDEFVKTRSDPIARTDSYKPSSE-PKPVPVPE 1223
                         :|  |.||.     ..||.:|...|...:|....|   ||:|. |.| |.|.
pombe  1205 -------------FVVNTRAGK-----NRKTNVSANNVSQGTDSRLVT---KPTSTFPSP-PSPP 1247

  Fly  1224 QITNWRERVSTPTNKP----QPAPNNWRINRSSSRQQGGS 1259
            ..:.|.:|...|  ||    |..|....|::|.|:...|:
pombe  1248 SSSVWNKREHHP--KPFSLHQVPPPESLIHKSKSKFSKGN 1285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pcm	NP_001162796.1	XRN1	1..843	CDD:227382	366/959 (38%)
		XRN1_D2_D3	811..889	CDD:436419	18/84 (21%)
		SH3_12	1060..1137	CDD:465661	23/83 (28%)
		XRN1_DBM	1329..1351	CDD:408065
exo2	NP_593482.1	XRN1	1..932	CDD:227382	367/965 (38%)
		XRN1_D2_D3	895..980	CDD:436419	20/93 (22%)
		Xrn1_D3	1060..1125	CDD:465674	15/74 (20%)
		SH3_12	1133..1199	CDD:465661	24/103 (23%)