Protein Alignment pcm and Xrn2

DIOPT Version :10

• Sequence 1: NP_001162796.1
• Gene: pcm / 32935
• FlyBaseID: FBgn0020261
• Length: 1613
• Species: Drosophila melanogaster
• Sequence 2: NP_036047.2
• Gene: Xrn2 / 24128
• MGIID: 894687
• Length: 951
• Species: Mus musculus
• Alignment Length: 817
• Identity: 308/817 - (37%)
• Similarity: 413/817 - (50%)
• Gaps: 179/817 - (21%)

  Fly     1 MGVPKFFRYISERYP-----CLSELAREHC----IP-----------EFDNLYLDMNGIVHNCSH 45
            ||||.|||::|.:||     |:.|..:| |    ||           ||||||||||||:|.|:|
Mouse     1 MGVPAFFRWLSRKYPSIIVNCVEEKPKE-CNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTH 64

  Fly    46 PDDNNIHFHLEEEQIFQEIFNYVDKLFYLIKPQRLFFLSVDGVAPRAKMNQQRSRRFRTAREAEQ 110
            |:|...  ...|:::...||.|:|:||.:::|:||.::::||||||||||||||||||.::|.
Mouse    65 PEDKPA--PKNEDEMMVAIFEYIDRLFNIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEG-- 125

  Fly   111 QEAKAAQRGELREH--------------ERFDSNCITPGTEFMVRLQEGLRAFLKTKISTDPLWQ 161
            .|| |.::..:||.              |||||||||||||||..|.:.||.::..:::.||.|:
Mouse   126 MEA-AVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWK 189

  Fly   162 RCTVILSGQEAPGEGEHKIMDYIRYMKTQPDYDPNTRHCLYGLDADLIILGLCTHELHFVVLREE 226
            ..|||||...||||||||||||||..:.||::||||.|||.|.|||||:|||.|||.:|.::|||
Mouse   190 NLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREE 254

  Fly   227 VK------------FGRNVK------------------RTSVEETRFFLLHLGLLREYLELEFDA 261
            .|            ||..||                  .....|..|..|.|.:||||||.|. .
Mouse   255 FKPNKPKPCALCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEFIFLRLNVLREYLEREL-T 318

  Fly   262 LRTDEHKLDIAQLIDDWVLMGFLVGNDFIPHLPCLHISSNALPLLYRTYIGIYPTLGGNINENGK 326
            :.:.....|:.:.|||||.|.|.|||||:||||.|.|...|:..|...|..:....||.:.|:|.
Mouse   319 MASLPFPFDVERSIDDWVFMCFFVGNDFLPHLPSLEIREGAIDRLVNIYKNVVHKTGGYLTESGY 383

  Fly   327 LNLRRLQIFISALTEVELDHFKEHADD-----------LKYM----------------------- 357
            :||:|:|:.:.|:.|||...||:..||           .|.|
Mouse   384 VNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNS 448

  Fly   358 -------NNKSEAFDMDV-----GEITESQNLDSD-----LGALINKSMLLYDDDSEEDCSDENA 405
                   |.:..|::|.:     ..|:.:.:..||     ||.:..|:     :||:.:...|:.
Mouse   449 PGCQVASNPRQAAYEMRMQRNSSPSISPNTSFASDGSPSPLGGIKRKA-----EDSDSEPEPEDN 508

  Fly   406 VLLKEFQNYKRNFYRNKFKRDPNDELI-EELCHHYVNALQWVLDYYYRGVQSWDWYYPFHYTPFI 469
            |.|.| ..:|:.:|:|||..|..||.. .::...||..|.|||.|||:|..||.|||||||.||.
Mouse   509 VRLWE-AGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFA 572

  Fly   470 SDLKNIEQVEIAFHMGT-PFLPFQQLLAVLPAASAKLLPVAYHDLMLLPTSPLAEFYPLEFESDL 533
            ||.:.|..:...|..|| ||.|.:||:.|.||||...||..:..||..|.|.:.:|||.:|..||
Mouse   573 SDFEGIADMSSEFEKGTKPFKPLEQLMGVFPAASGNFLPPTWRKLMSDPDSSIIDFYPEDFAIDL 637

  Fly   534 NGKKHDWEAVVLIPFIDEGRLLAAMLPCEAQLSLEERERNRHG--PMYVYK-----------YST 585
            ||||:.|:.|.|:||:||.||.||:......|:.||..||..|  .::|.|           |.|
Mouse   638 NGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEENRRNSLGGDVLFVGKLHPLRDFILELYQT 702

  Fly   586 VAQGPMPAYPPLRALPVLYCTEV-AKWSHEIAVNLP-YSVCIELP-------NAARTVFF--PGF 639
            .:..|:...|.|       |..: ..:|.:....|| .:||..:|       |.|.::.|  |.|
Mouse   703 GSTEPVDVPPEL-------CHGIQGTFSLDEEAILPDQTVCSPVPMLRDLTQNTAVSINFKDPQF 760

  Fly   640 PTMQHLPFDFELRNDRVKVFEQV----SRNQNIVLKP 672
            ..      |:        ||:..    :|....||||
Mouse   761 AE------DY--------VFKAAMLPGARKPATVLKP 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pcm	NP_001162796.1	XRN1	1..843	CDD:227382	308/817 (38%)
		XRN1_D2_D3	811..889	CDD:436419
		SH3_12	1060..1137	CDD:465661
		XRN1_DBM	1329..1351	CDD:408065
Xrn2	NP_036047.2	XRN1	1..787	CDD:227382	308/817 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..508		16/104 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	907..951