DRSC/TRiP Functional Genomics Resources

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Protein Alignment pcm and XRN2

DIOPT Version :9

Sequence 1:NP_001162796.1 Gene:pcm / 32935 FlyBaseID:FBgn0020261 Length:1613 Species:Drosophila melanogaster
Sequence 2:NP_001304889.1 Gene:XRN2 / 22803 HGNCID:12836 Length:1028 Species:Homo sapiens


Alignment Length:802 Identity:293/802 - (36%)
Similarity:401/802 - (50%) Gaps:156/802 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 EFDNLYLDMNGIVHNCSHPDDNNIHFHLEEEQIFQEIFNYVDKLFYLIKPQRLFFLSVDGVAPRA 92
            ||||||||||||:|.|:||:|...  ...|:::...||.|:|:||.:::|:||.::::|||||||
Human   125 EFDNLYLDMNGIIHPCTHPEDKPA--PKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRA 187

  Fly    93 KMNQQRSRRFRTAREAEQQEAKAAQRGELREH--------------ERFDSNCITPGTEFMVRLQ 143
            |||||||||||.::|.  .|| |.::..:||.              |||||||||||||||..|.
Human   188 KMNQQRSRRFRASKEG--MEA-AVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLA 249

  Fly   144 EGLRAFLKTKISTDPLWQRCTVILSGQEAPGEGEHKIMDYIRYMKTQPDYDPNTRHCLYGLDADL 208
            :.||.::..:::.||.|:..|||||...||||||||||||||..:.||::||||.|||.|.||||
Human   250 KCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADL 314

  Fly   209 IILGLCTHELHFVVLREEVK------------FGRNVK------------------RTSVEETRF 243
            |:|||.|||.:|.::|||.|            ||..||                  .....|..|
Human   315 IMLGLATHEPNFTIIREEFKPNKPKPCGLCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEF 379

  Fly   244 FLLHLGLLREYLELEFDALRTDEHKLDIAQLIDDWVLMGFLVGNDFIPHLPCLHISSNALPLLYR 308
            ..|.|.:||||||.|. .:.:.....|:.:.|||||.|.|.|||||:||||.|.|..||:..|..
Human   380 IFLRLNVLREYLEREL-TMASLPFTFDVERSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVN 443

  Fly   309 TYIGIYPTLGGNINENGKLNLRRLQIFISALTEVELDHFKEHADD-------------------- 353
            .|..:....||.:.|:|.:||:|:|:.:.|:.|||...||:..||                    
Human   444 IYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQP 508

  Fly   354 ---------------------------------LKYMNNKSEAFDMDVGEITESQNLDSDLGALI 385
                                             ::..||.|.:...:..  ..|....|.||.:.
Human   509 AFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTS--FTSDGSPSPLGGIK 571

  Fly   386 NKSMLLYDDDSEEDCSDENAVLLKEFQNYKRNFYRNKFKRDPNDELI-EELCHHYVNALQWVLDY 449
            .|:     :||:.:...|:.|.|.| ..:|:.:|:|||..|..||.. .::...||..|.|||.|
Human   572 RKA-----EDSDSEPEPEDNVRLWE-AGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRY 630

  Fly   450 YYRGVQSWDWYYPFHYTPFISDLKNIEQVEIAFHMGT-PFLPFQQLLAVLPAASAKLLPVAYHDL 513
            ||:|..||.|||||||.||.||.:.|..:...|..|| ||.|.:||:.|.||||...||.::..|
Human   631 YYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKL 695

  Fly   514 MLLPTSPLAEFYPLEFESDLNGKKHDWEAVVLIPFIDEGRLLAAMLPCEAQLSLEERERN----- 573
            |..|.|.:.:|||.:|..||||||:.|:.|.|:||:||.||.||:......|:.||..||     
Human   696 MSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGD 760

  Fly   574 -----RHGPMYVY---KYSTVAQGPMPAYPPL-------------RALP-VLYCTEVAKWSHEIA 616
                 :|.|::.:   .|.|.:..|:...|.|             ..|| .:.|:.| ....::.
Human   761 VLFVGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPV-PMLRDLT 824

  Fly   617 VNLPYSVCIELPNAA-----RTVFFPGF--PTMQHLPFDFELRNDRVKVFEQVSRNQNIVLKPRK 674
            .|...|:..:.|..|     :.|..||.  |.....|.|:|..::..:...|:..|::      :
Human   825 QNTVVSINFKDPQFAEDYIFKAVMLPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRD------R 883

  Fly   675 RQLEDTLTAVASQYLGKVIHVG 696
            |.:.  |...|.:.||.|:..|
Human   884 RPVH--LDQAAFRTLGHVMPRG 903

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pcmNP_001162796.1 XRN1 1..843 CDD:227382 293/802 (37%)
XRN_N 1..225 CDD:281193 113/210 (54%)
XRN2NP_001304889.1 XRN_N 113..331 CDD:281193 113/210 (54%)
XRN1 118..865 CDD:227382 283/754 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5049
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D150649at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100417
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.720

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