Protein Alignment pcm and xrn-1

DIOPT Version :10

• Sequence 1: NP_001162796.1
• Gene: pcm / 32935
• FlyBaseID: FBgn0020261
• Length: 1613
• Species: Drosophila melanogaster
• Sequence 2: NP_496945.3
• Gene: xrn-1 / 175059
• WormBaseID: WBGene00012730
• Length: 1591
• Species: Caenorhabditis elegans
• Alignment Length: 1785
• Identity: 554/1785 - (31%)
• Similarity: 837/1785 - (46%)
• Gaps: 386/1785 - (21%)

  Fly     1 MGVPKFFRYISERYPCLSELAREHCIPEFDNLYLDMNGIVHNCSHPDDNNIHFHLEEEQIFQEIF 65
            ||||||:|:.|||||||||:..|..||||||||||||||:||||||:|:::.|.:.|::||..||
 Worm     1 MGVPKFYRWTSERYPCLSEVINESQIPEFDNLYLDMNGIIHNCSHPNDDDVTFRITEDEIFVNIF 65

  Fly    66 NYVDKLFYLIKPQRLFFLSVDGVAPRAKMNQQRSRRFRTAREAEQQEAKAAQRGELREHE-RFDS 129
            .|::.|:.||:||::||::||||||||||||||:|||.:||.|..|.|||.:.||:...| ||||
 Worm    66 AYIENLYNLIRPQKVFFMAVDGVAPRAKMNQQRARRFMSARTAHTQLAKALENGEIMPSEARFDS 130

  Fly   130 NCITPGTEFMVRLQEGLRAFLKTKISTDPLWQRCTVILSGQEAPGEGEHKIMDYIRYMKTQPDYD 194
            |||||||.||.||.:.|..::|||.:||..||...:||||...||||||||||:||..:....||
 Worm   131 NCITPGTYFMTRLHQKLDDWIKTKSATDSRWQGRKIILSGHNVPGEGEHKIMDFIRTERAGSSYD 195

  Fly   195 PNTRHCLYGLDADLIILGLCTHELHFVVLREEVKFG-----------RNVKRTSVEETRFFLLHL 248
            ||||||:||||||||:||:.:||.||.:|||||.|.           :..|||..:..:|.||||
 Worm   196 PNTRHCMYGLDADLIMLGIVSHEPHFSLLREEVTFNTRPRKNDNKATKKPKRTDSDVKKFHLLHL 260

  Fly   249 GLLREYLELEF-DALRTDEHKLDIAQLIDDWVLMGFLVGNDFIPHLPCLHISSNALPLLYRTYIG 312
            .||||||..|| |...:...:.::.:::|||:|:|.||||||:||||.:||..:||||||.||..
 Worm   261 SLLREYLAWEFADVKDSLPFEYEMERIVDDWILLGLLVGNDFLPHLPNIHIHDDALPLLYSTYKK 325

  Fly   313 IYPTLGGNINENGKLNLRRLQIFISALTEVELDHFKEHADDLKYMNNKS-EAFDMDVGEIT---- 372
            :.|||.|.|||.|.|||.|.:.|::.|...:...|.|..:|.::|.:|. ...|.:..|:.
 Worm   326 VLPTLDGYINEAGYLNLSRFEAFLAELALNDKTSFMERLEDEQFMESKRIRVVDPEQQELAEPEL 390

  Fly   373 ---ESQNLDSDLGALINK-----------------------------------SMLLYDDDS--- 396
               ||.:::.:.||..:|                                   .:||.:.|:
 Worm   391 VAFESSDVEDEAGAEESKDEAGGAGAEDDEDDAAFVSDHEEDGDDLEPGSGSDELLLSNLDAQLL 455

  Fly   397 EEDCSDENAVLL----------------------KEFQNYKRNFYRNKFK-RDPNDELIEELCHH 438
            |::.:||.|.|.                      .:|:.:|:.:|.:|.: ::.:.:.:.|....
 Worm   456 EDEFNDELATLALSGMNDADFANDVEACWTKTINNQFKRHKKTYYSDKLRYKNISKQQLREQAEG 520

  Fly   439 YVNALQWVLDYYYRGVQSWDWYYPFHYTPFISDLKNIEQVEIAFHMGTPFLPFQQLLAVLPAASA 503
            ||.|:||.|.|||.|..||.|:||.||.|||||::....:.:.|.:..||.||:|||||||.|||
 Worm   521 YVRAIQWNLHYYYHGCVSWSWFYPHHYAPFISDVRGFVGMRMEFELSEPFHPFEQLLAVLPEASA 585

  Fly   504 KLLPVAYHDLMLL--PTSPLAEFYPLEFESDLNGKKHDWEAVVLIPFIDEGRLLAAMLPCEAQLS 566
            ..||....:||..  ..||:.:|||..||:|||||:::||||||||||:|.|||.|:....::|:
 Worm   586 DCLPRPLRELMSSDPAKSPICDFYPANFETDLNGKRNEWEAVVLIPFIEEKRLLEAIEAKRSRLT 650

  Fly   567 LEERERNRHG-----------PMYVYKYSTV-AQGPMPAYPPLRALPVLYCTEVAKWSHEIAVNL 619
            .||..||.||           |....::.|| ::.|..::...|:        ..||.
 Worm   651 SEENARNSHGSHIQCISSPEPPNSQGQWRTVRSEIPQDSFRIPRS--------QVKWG------- 700

  Fly   620 PYSVCIELPNAARTVFFPGFPTMQHLPFDFELRNDRVKVFEQVSRNQNIVLKPRKRQLEDTLTAV 684
                  .|||....|:|||||||:||....|||.....:|...||.:::|||....:....:..:
 Worm   701 ------LLPNVKMDVYFPGFPTMKHLSHLGELRFANCNIFGMASRKESMVLKVENERAHTDIIEL 759

  Fly   685 ASQYLGKVIHVGWPHLVKAIVVRVATRDQRV----DSEGITLN----DSRRFDSECKALQEHFIN 741
            .|:...:.:.:.||.|..|.:..:...|.::    |.|.|..:    :.|::.:....|.||.:.
 Worm   760 GSELCDEEVCIDWPILKVAKIDSIWGGDDKIVRKCDDEIIVKDMSEEEKRQWQAHANQLTEHLMT 824

  Fly   742 RMGIQFANY---------DVLVYVRTFAGNSTEFRDKG----ALMVRDSWSSSVTGYPAQGVVAD 793
            |..|:.|..         ..:.:||.|.|...|.:..|    .|.....|||.....|   |:..
 Worm   825 RFAIEIAAQKDSKGKHIRPAVAWVRKFTGLVYEAQGGGKEPSVLKACKQWSSPQQLMP---VLLP 886

  Fly   794 LTVWERMRKNF-----LNVEHYFPVGSTIFLITDP---YYGSEGTVQDPRLAYTNG-----RIQV 845
            |.|.:.:.:|.     |.::..:|..|.:: ||||   .:|..|.|.    .::|.     ||:|
 Worm   887 LVVKDVLLENSRVLADLPMKQAYPKQSIVW-ITDPKFALFGMPGMVN----GFSNEKSADCRIEV 946

  Fly   846 SIMVRPE--PKVNAARQLQEERDRDYLSTFQVCNLLRISGRTLGRLSGTVWVVLGPR------RQ 902
            ..|....  .|:.|.|:..|::...::..:......::..|...|::||:::...||      :|
 Worm   947 IGMSTQNKVDKMEALRKKMEQKSLRWMGGYDCARQCQVDTRLFARITGTMFLWNEPRERVEKGQQ 1011

  Fly   903 KMENVTKHNIGLQLKYPRQNEERAGYCFR---------TNNQWYYSSLAVDLMRNYCQRYPDV-- 956
            ...:.:|.|.||.|||.|::...|.|..|         ||..|:|::||..|:..|.:::|||
 Worm  1012 ISSSDSKINCGLALKYSRRDLCVADYTDRTEHTNQRGVTNKVWFYTNLATRLVSEYRRKFPDVWK 1076

  Fly   957 -IDFFGDSNDRAEFVFEQDVFPN-AVGHRRVEELANWVRQQPHMKVERISCGSKTVCRE---TIE 1016
             ::..| ...:.:..:.:|::.| ....:|..||:.::...|.::.|::.||:....|:   .||
 Worm  1077 YLETIG-LTQQDDVYYTEDIWSNEKTREKRFGELSEFLGGLPSLEAEQLKCGTVYADRQLITEIE 1140

  Fly  1017 LLIAAVDDLRSLPVKHVKLQVKPHLLIKPNVTLPDVYRSK------RPVRLFDRVVIVRTIYMVP 1075
            :::|..|:.:  ||.: |..:.|..|.:     .::|..|      ...::.|||.::.:...||
 Worm  1141 MILAEPDEKK--PVMN-KYMMAPGALFR-----YELYNGKVHADPAADFQILDRVALMSSDTKVP 1197

  Fly  1076 VGTKGTVIGIHPVTDPNPVRLECVHAVDTFCKVLFDSPVPNCNNIHGIAEDRVYKVPEIALV--- 1137
            ..|:|||:|||                |....|.||.|......:.|..|....:||:.||:
 Worm  1198 KTTQGTVVGIH----------------DDKIDVFFDKPFDGGQKVRGSNEAAAIRVPQSALLNVT 1246

  Fly  1138 --IIKTDEEGKKQNDCEL-----PVRDPQPNQAQDEPVRATSSRYVTAAGSTSVPITMKTQISDE 1195
              |::.:.:.|||.:..|     |: ..|.|.|::||..:|||   :.:.||:.......:..::
 Worm  1247 FGIVRKNVQHKKQVEKALTGAYVPM-PAQKNSAKNEPAPSTSS---SNSNSTNNKKNSSKKEKNK 1307

  Fly  1196 FVKTRSD---PIARTDSYKPSSEPKPVPVPEQITNWRERVSTPTNKPQPAPNNWRINRSSSRQQG 1257
            ...|::|   |.|.|||.....:.|| |..|                  |.:..:::.......|
 Worm  1308 QKPTKTDEESPEALTDSLNKLLKIKP-PSAE------------------ATSGKQVSLMELLGGG 1353

  Fly  1258 GSIFVAPPTKTPDAAASTASTAFTAASSATLTPLDQTLALMSVLGVGEDQSSP-PLQEAVQQQRP 1321
            |:.....|.:.....|...|.:..:||.:         :::..|...:..::| |.:||.|:::.
 Worm  1354 GAAGAKKPAQNAKTLAEIESDSSQSASKS---------SILQQLSAAQKAAAPKPKKEASQKKQK 1409

  Fly  1322 PLLQQQRAPFPGQM-----PNLPKPPLFWQQEAQKQEALQQEAQQQEAQKKQQQAHAQMEPERIN 1381
            |    |.|| |.::     |..|.||                     ..::|:.|.|
 Worm  1410 P----QAAP-PQKVEILRKPTPPPPP---------------------PAEEQKPAPA-------- 1440

  Fly  1382 SQHFYRSGQTGAALNQPPLGAPSKRQWHEWVHPRMQHANAFHAGVNNGYQMRPKKNIAAQSTFNN 1446
                             |.|||:......:....:|.|.  |..:..||.|            ..
 Worm  1441 -----------------PFGAPTPPPQFPFGPQPLQFAP--HPMMMMGYPM------------GM 1474

  Fly  1447 NVHMHLQQPYYPNQQQQQQQQQPLQLTEINNAPPRYSTIQDFVPIQAYRPKKLNRVQPAGRQDVD 1511
            .:.|.:..|::..|||.||:::.       |.|    |:.||.|...:|           ||  :
 Worm  1475 PMGMPIGGPHHYQQQQNQQEKRA-------NHP----TLTDFKPSAVHR-----------RQ--N 1515

  Fly  1512 ATKNPSRSPVLQQPTNETIDTKASSSLPVQSAGEQVIGLMQTLEIKQPAASQSESDGVSTGSANA 1576
            ..:.||     .||...|:.||.:||                     |...:.|.|.......::
 Worm  1516 CHQRPS-----NQPPKVTMITKRTSS---------------------PTPPEKEEDAAPRALPSS 1554

  Fly  1577 PTATTSSQAVNR------RKHRVPRIGAKF 1600
            |...:.|.|..:      ||.:..|:|:.|
 Worm  1555 PPPPSKSAAEEKTTTKKPRKKKQSRLGSNF 1584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pcm	NP_001162796.1	XRN1	1..843	CDD:227382	373/971 (38%)
		XRN1_D2_D3	811..889	CDD:436419	19/87 (22%)
		SH3_12	1060..1137	CDD:465661	22/76 (29%)
		XRN1_DBM	1329..1351	CDD:408065	7/26 (27%)
xrn-1	NP_496945.3	XRN1	1..782	CDD:227382	336/801 (42%)
		SH3_12	1179..1244	CDD:465661	23/80 (29%)