DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pcm and pcm

DIOPT Version :10

Sequence 1:NP_001162796.1 Gene:pcm / 32935 FlyBaseID:FBgn0020261 Length:1613 Species:Drosophila melanogaster
Sequence 2:XP_313715.6 Gene:pcm / 1274572 VectorBaseID:AGAMI1_007906 Length:1707 Species:Anopheles gambiae


Alignment Length:1749 Identity:641/1749 - (36%)
Similarity:901/1749 - (51%) Gaps:241/1749 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGVPKFFRYISERYPCLSELAREHCIPEFDNLYLDMNGIVHNCSHPDDNNIHFHLEEEQIFQEIF 65
            |||||||||:||||||||||.||:.:|||||||||||||:||||||:|.::||.:.||.||:.||
Mosquito     1 MGVPKFFRYMSERYPCLSELLRENQVPEFDNLYLDMNGIIHNCSHPNDADVHFRISEEMIFEGIF 65

  Fly    66 NYVDKLFYLIKPQRLFFLSVDGVAPRAKMNQQRSRRFRTAREAEQQEAKAAQRG-ELREHERFDS 129
            :||:.||.||:||::||::||||||||||||||.||||:|.||:....||..:| |:.....|||
Mosquito    66 HYVEYLFKLIRPQQVFFIAVDGVAPRAKMNQQRGRRFRSAAEAQDLLEKAKAKGEEISSESPFDS 130

  Fly   130 NCITPGTEFMVRLQEGLRAFLKTKISTDPLWQRCTVILSGQEAPGEGEHKIMDYIRYMKTQPDYD 194
            |||||||.||||||..|:.|::.||:||.||:.|||||||.|.|||||||||:|||:.|.||.::
Mosquito   131 NCITPGTSFMVRLQNALQHFIQVKIATDRLWKACTVILSGHETPGEGEHKIMEYIRHAKAQPGFN 195

  Fly   195 PNTRHCLYGLDADLIILGLCTHELHFVVLREEVKFGRNVKRTS-VEETRFFLLHLGLLREYLELE 258
            |||||||||||||||:|||||||.:|.:||||||||:|.|:|| ::|.||:||||.||.||||||
Mosquito   196 PNTRHCLYGLDADLIMLGLCTHERYFSLLREEVKFGKNDKKTSNLKEIRFYLLHLTLLSEYLELE 260

  Fly   259 FDALRTD-EHKLDIAQLIDDWVLMGFLVGNDFIPHLPCLHISSNALPLLYRTYIGIYPTLGGNIN 322
            |.::|.. ....||.:|||||:|:.:|||||||||:|.|||:.||||.||..|:.:.|.:.|.||
Mosquito   261 FASVRDRLRFPFDIHKLIDDWILLVYLVGNDFIPHMPHLHINENALPTLYEAYMDVLPNMDGYIN 325

  Fly   323 ENGKLNLRRLQIFISALTEVELDHFKEHADDLKYM-----NNKSEAFDMDVGEITESQNLDSDLG 382
            |.|.|||.|||:.:..|...:.|.|.:...||||:     .|..:|||:|..||..:..:|.||.
Mosquito   326 EAGILNLPRLQMLMRRLANFDRDMFLDRYTDLKYLEGKCGKNNLDAFDVDANEIIGASEMDKDLM 390

  Fly   383 ALINKSMLLYDDDSEE--------DCSDENAVLLKEFQNYKRNFYRNKF-KRDPNDELIEELCHH 438
            |||..|.:| |.:.|:        |..::..:..:||:|||||:|.:|. ..|..:|:..|....
Mosquito   391 ALIMSSEML-DSEGEDNAAPVTLGDIENDPELFEQEFKNYKRNYYMSKMGYADFTEEVRAEQAEC 454

  Fly   439 YVNALQWVLDYYYRGVQSWDWYYPFHYTPFISDLKNIEQVEIAFHMGTPFLPFQQLLAVLPAASA 503
            |:.||||.|.||||||.||.||||.||.|||||:.|...:::.:.:..|||||||||:||||||.
Mosquito   455 YIRALQWTLHYYYRGVVSWSWYYPHHYAPFISDVDNFAHLKLDYELARPFLPFQQLLSVLPAASK 519

  Fly   504 KLLPVAYHDLMLLPTSPLAEFYPLEFESDLNGKKHDWEAVVLIPFIDEGRLLAAMLPCEAQLSLE 568
            :.||.|||.||..|.|.:.:|||:.|.:|||||:..||||||||||||.|||.||.||:|.|:.|
Mosquito   520 QHLPSAYHQLMTDPNSSVYDFYPVNFATDLNGKQQAWEAVVLIPFIDEKRLLKAMGPCDAFLTDE 584

  Fly   569 ERERNRHGPMYVYKYSTVAQGPMPAYPPLRALPVLY--CTEVAKWSHEIAVNLPYSVCIELPNAA 631
            |::||.||||..|:|.|....|:.|......:..|:  |:|:  |..::.|.....|......|.
Mosquito   585 EKQRNVHGPMLKYQYDTKQHAPLEAKYGFDRVDELHVKCSEI--WRDDLRVAENRLVLGPSQGAV 647

  Fly   632 RTVFFPGFPTMQHLPFDFELRNDRVKVFEQVSRNQN--IVLKPRKRQLEDTLTAVASQYLGKVIH 694
            ...:..||||..|||:..||:..|||:|...|:|::  :||.....|..|| ..:|.:.||||:|
Mosquito   648 LHGYAKGFPTFAHLPYHGELKELRVKIFNFASKNESMVVVLDTPDGQSSDT-AELAKELLGKVVH 711

  Fly   695 VGWPHLVKAIVVRVATRDQRVDSEGITL-NDSRRFDSECKALQEHFINRMGIQFANYDVLVYVRT 758
            |.||||::||||||:.|.:..:.....| .|.|.|:..|:::.||..||:.|.......||:||.
Mosquito   712 VSWPHLMEAIVVRVSDRSKTYERNSEPLPTDERSFNMWCRSIIEHNNNRLAINVGTIKQLVHVRI 776

  Fly   759 FAGNSTEFRDKGALMVRDSWSSSVTGYPAQGVVADLTVWERMRKNFLNVEHYFPVGSTIFLITDP 823
            ..|.....:|.| .:::..|::..|.||||.::.||......:|.::.:|..||..|.:||....
Mosquito   777 AVGTEYVLKDNG-FVLKKLWNTIDTAYPAQTIIQDLQDIMAKQKPYIEMEEMFPRESVVFLRATE 840

  Fly   824 YYGSEGTVQDPRLAYTNGRIQVSIMVRPEPKVNAARQLQEERDRDYLSTFQVCNLLRISGRTLGR 888
            :|||.|.|.|  ::.:..|:|...:|..||.:.....:..:..:.|.:......:|.||...|.:
Mosquito   841 FYGSMGNVVD--VSGSTKRVQARFLVYEEPDLGQVYNVHRQSLQGYRNANDTAAMLGISVGLLLQ 903

  Fly   889 LSGTVWVVLGPRRQKMENVTKHNIGLQLKYPRQNEERAGYCFRTNNQWYYSSLAVDLMRNYCQRY 953
            |:|::.|..|..|....:....||||:|:...::||..|||.:.|..|.:|...|.||:.|.:|.
Mosquito   904 LTGSILVAPGGHRALNVDEKSLNIGLRLRMISKDEEAVGYCRKVNKTWLFSDKTVKLMQQYMERA 968

  Fly   954 PDVIDFFGDSNDRAEFVFEQDVFPNAVGHRRVEELANWVRQQPHMKVERISCGSKTVCRETIELL 1018
            |.:.:.. |.:.:....||.|:|... ...:::||.:|::.|.|:..||.|||...:..:.||.|
Mosquito   969 PGLFEKL-DCSRKTNVHFETDLFGEG-NEGKLQELYDWLKVQEHVNSERRSCGIILLEEKAIEAL 1031

  Fly  1019 IAAVDDLRSLPVKHVK-LQVKPHLLIKPNVTLPDVYRSKRPVRLFDRVVIVRTIYMVPVGTKGTV 1082
            ...:|..::|....|: :.|.|..|.:|.:....:........|.||:::|:....||||.:||:
Mosquito  1032 AETIDKYQTLHQPKVQTMFVDPKELYRPGMKNAKMIDPSAHFELLDRIIVVQEKEDVPVGARGTI 1096

  Fly  1083 IGIHPVTDPNPVRLECVHAVDTFCKVLFDSPVPNCNNIHGIA--EDRVYKVPEIALVIIKTDEEG 1145
            ||||.|:||||||.|.:...||..:||||.|.....:|:.|:  |.||.::.:..::.|   ..|
Mosquito  1097 IGIHRVSDPNPVRREAIGQEDTNFEVLFDKPFYKGVDIYNISSTEKRVLRLSQSVIMNI---SHG 1158

  Fly  1146 KKQNDCELPVRDPQPNQAQDEPVRATSSRYVTAAGSTSVPITMKTQISDEFVKTRSD-----PIA 1205
            |........:...:.|..:.|...||..|....:.:|:..|..:.   :|.:..||:     .:|
Mosquito  1159 KASAGYRYKISVDRSNAVRKETPAATEGRSANKSMATAESIQRRV---NERIGKRSNAMNNVSLA 1220

  Fly  1206 RTDSYKPSSE--------------------------PK---------------PVPVPEQITNWR 1229
            .|.:.:|:.:                          ||               ..| |.:.::||
Mosquito  1221 GTSATRPTEQNVMQQKDGDQQRKIEFERLWRKLKESPKAPGELFDAMDIQNIVQAP-PAEKSSWR 1284

  Fly  1230 ERVSTPTNKPQPAPNNW-------------RINRSSSRQQGGSIFVAP----------------- 1264
            .:.......|:.....|             ||:..:..::|....|.|                 
Mosquito  1285 RKPEDDATLPKKDGEQWNGDNMTGYLKQMLRIDEKAGSEKGSEKSVNPASIAVPAPASLPKPPIQ 1349

  Fly  1265 ---------PTKTPDAAA----------STASTAFTAASSATLTPLDQTLALMSVLGVG------ 1304
                     |.|.|.|..          :|.:||....:....||..|..::...:.:|      
Mosquito  1350 WQTQAASKSPAKGPTAVPLTEVNETTKNNTNNTANQFIAQYMKTPQPQMASMAQPMHLGFRPMLR 1414

  Fly  1305 -----------EDQSSPPLQEAV----------------QQQRPPLLQ----QQRAPFPGQMP-N 1337
                       :.|..|.:.:.|                |...||..|    :...|||.:|. |
Mosquito  1415 PPTHTFDPRHPQPQFGPMIMQPVFMQTGTNMHQSMGAFQQPAMPPFPQNMPMRPPVPFPNRMENN 1479

  Fly  1338 LPKPP-----------LFWQQEAQKQEALQQEAQQQEAQKKQQQAHAQMEPERINS------QHF 1385
            :|.||           :..||:.|:|:..||:.|||..|:|||.   |::|...::      ||.
Mosquito  1480 VPFPPHGHGLNNAPAKMMVQQQQQQQQQQQQQHQQQHHQQKQQH---QVQPHYPSNWGPKGPQHL 1541

  Fly  1386 -YRSGQ---TGAALNQPPLGAPSKRQWHEWVHPRMQHANAFHAGVNNGYQMRPKKNI---AAQST 1443
             |....   .||.:   ||.|..|.            |.....|.:.........|:   ||..|
Mosquito  1542 SYNKNNPAGNGAFV---PLQAMKKT------------AKGKSGGGSGSANYSNVSNVAAAAASET 1591

  Fly  1444 FNNNVHMHLQQPYYPNQQQQQQQQQPLQLTEINNAPPRYSTIQDFVPIQAYRPKKLNRVQPAGRQ 1508
            .|:                |..:.||...::.|.     .|...|....|.|.:::.:.|...:|
Mosquito  1592 LNS----------------QNVKNQPTPPSKTNG-----QTTGGFNEKNARRRQEVEQKQAEVKQ 1635

  Fly  1509 DVDATKNPSRSPVLQQPT--NETIDTKASSSLPVQSAGEQVIGLMQTLEIKQPAASQSE 1565
            .. ||....:|...||..  |....|....|..|.:..:|...:..|..:|| |.|:|:
Mosquito  1636 GF-ATFLSQKSDTKQQKNKHNSNTSTAKKQSTVVTAVKDQDGQIEDTSVVKQ-APSKSK 1692

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pcmNP_001162796.1 XRN1 1..843 CDD:227382 436/863 (51%)
XRN1_D2_D3 811..889 CDD:436419 21/77 (27%)
SH3_12 1060..1137 CDD:465661 34/78 (44%)
XRN1_DBM 1329..1351 CDD:408065 10/33 (30%)
pcmXP_313715.6 None

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