DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Naa15-16 and NAA15

DIOPT Version :9

Sequence 1:	NP_001285439.1	Gene:	Naa15-16 / 32934	FlyBaseID:	FBgn0031020	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_476516.1	Gene:	NAA15 / 80155	HGNCID:	30782	Length:	866	Species:	Homo sapiens

Alignment Length:	893	Identity:	467/893 - (52%)
Similarity:	625/893 - (69%)	Gaps:	39/893 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSSDPLPPKEGALFRKLLKCYELKQYKNGLKLAKQILSNPKYMEHGETLAMKGLTLNGLGRREE 65
            ||:.. |||||.|||:::|:|||.|||:||||..||||||||:.||||||||||||||.||::||
Human     1 MPAVS-LPPKENALFKRILRCYEHKQYRNGLKFCKQILSNPKFAEHGETLAMKGLTLNCLGKKEE 64

  Fly    66 AYKYVRLGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRD 130
            ||:.||.||||||:|||||||||||||||||||||||||||||||:|||||||:|||||||||||
Human    65 AYELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWDKDNLQILRDLSLLQIQMRD 129

  Fly   131 LEGYKETRHHLFTLRPSQHASWIGFAMSYHLLGDYDMANSILETFSQS-QTSIEAHDYRHSELLL 194
            ||||:|||:.|..|||:|.|||||:|::||||.||:||..|||.|.:: |||.:..||.:|||||
Human   130 LEGYRETRYQLLQLRPAQRASWIGYAIAYHLLEDYEMAAKILEEFRKTQQTSPDKVDYEYSELLL 194

  Fly   195 YQNQILIESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVL 259
            ||||:|.|:...::|::||..|:.||.|||||.||.|:|.::|.:.|.|..::..|..|||||..
Human   195 YQNQVLREAGLYREALEHLCTYEKQICDKLAVEETKGELLLQLCRLEDAADVYRGLQERNPENWA 259

  Fly   260 YYEQYIAARQVTDSSAVVSIYRVFQEQYPRALCPRRLPLNIANGDEFRVVTDEYLRRGLRKGIPP 324
            ||:....|.:..:....:.||.....:|||.|.|||||||..:|::|:...|::||....||.||
Human   260 YYKGLEKALKPANMLERLKIYEEAWTKYPRGLVPRRLPLNFLSGEKFKECLDKFLRMNFSKGCPP 324

  Fly   325 LFVNVRTLHQIPERAAVIEELALQYFENLTRSGHFSREDADAGIPVEPASALVWTALFLAQHYDY 389
            :|..:|:|::..|:.|:||||.:.|..:|.....|:..|..   ..||.:.|:|...:||||||.
Human   325 VFNTLRSLYKDKEKVAIIEELVVGYETSLKSCRLFNPNDDG---KEEPPTTLLWVQYYLAQHYDK 386

  Fly   390 MRDTDRALEYINVAIDHTPTLIELLITKGRIFKHAGDPVEAYVWLEEAQSMDTADRYINSKCAKY 454
            :.....||||||.||:.|||||||.:.|.:|:||||:..||..|::|||::|||||:||||||||
Human   387 IGQPSIALEYINTAIESTPTLIELFLVKAKIYKHAGNIKEAARWMDEAQALDTADRFINSKCAKY 451

  Fly   455 MLRANMVQEAEEICAKFTREGVSAMDNLNEMQCMWFQTECALAYQRMGRWGESLKKCHEVERHFA 519
            ||:||:::||||:|:||||||.||::|||||||||||||||.||:.|.::||:||||||:||||.
Human   452 MLKANLIKEAEEMCSKFTREGTSAVENLNEMQCMWFQTECAQAYKAMNKFGEALKKCHEIERHFI 516

  Fly   520 EIVEDQFDFHTYCMRKMTLRAYVGLLRLEDVLRQHPFYFKAAKCAIEVYIRLYDKPLKSETTIEE 584
            ||.:||||||||||||:|||:||.||:|||||||||||||||:.|||:|::|:|.||..|....|
Human   517 EITDDQFDFHTYCMRKITLRSYVDLLKLEDVLRQHPFYFKAARIAIEIYLKLHDNPLTDENKEHE 581

  Fly   585 IDIENLPPSELKKLRSKQRKAKKKAELESAQAAQAQVKREQHQKSKQQANQ--ETDPDAPQL--- 644
            .|..|:...||||||:|||:|:|||::|.        :::..:|.|||.||  :.|.|..::
Human   582 ADTANMSDKELKKLRNKQRRAQKKAQIEE--------EKKNAEKEKQQRNQKKKKDDDDEEIGGP 638

  Fly   645 -DELVAEKLERTDDPLDKAIEFLKPLQQLAKERIETHLLAFELYYRKNKLLLMLQCIRRARAVDA 708
             :||:.|||.:.:.||::||:||.||:.|.|.:|||||.|||:|:||.|.|||||.::||.|:|:
Human   639 KEELIPEKLAKVETPLEEAIKFLTPLKNLVKNKIETHLFAFEIYFRKEKFLLMLQSVKRAFAIDS 703

  Fly   709 SHPVIHSCIIRFVKSLTSAAKEQPFNEHVQQVLEKATKELIGSKTPQQLNDEFIAKHNASILHLY 773
            |||.:|.|:||...  |:..:.:..::.|:.||::....|.|:..|:..|:.|:.:::.|:.|..
Human   704 SHPWLHECMIRLFN--TAVCESKDLSDTVRTVLKQEMNRLFGATNPKNFNETFLKRNSDSLPHRL 766

  Fly   774 EGARSLYELDNSKKAAAIKLVTSF--NLAKLRLEEATKIYTALRDGDVFGECEAEAASYQQACHQ 836
            ..|:.:|.||.|.:..||:|.|:.  :|....|:...::..||.||.: |:|:..|..|:..||:
Human   767 SAAKMVYYLDPSSQKRAIELATTLDESLTNRNLQTCMEVLEALYDGSL-GDCKEAAEIYRANCHK 830

  Fly   837 RFQYARIFRNVEELEAQLQEKEAAKLRAEEEQQQLIHVDSSEPVSVLA 884
            .|.||..|               .....||:.:..::.|||.....||
Human   831 LFPYALAF---------------MPPGYEEDMKITVNGDSSAEAEELA 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naa15-16	NP_001285439.1	TPR repeat	13..39	CDD:276809	17/25 (68%)
		TPR repeat	48..75	CDD:276809	20/26 (77%)
		TPR repeat	83..109	CDD:276809	25/25 (100%)
		TPR repeat	114..144	CDD:276809	24/29 (83%)
		TPR repeat	149..173	CDD:276809	15/23 (65%)
		NARP1	187..703	CDD:289346	273/521 (52%)
		TPR repeat	410..440	CDD:276809	16/29 (55%)
		TPR repeat	445..470	CDD:276809	18/24 (75%)
NAA15	NP_476516.1	TPR repeat	12..38	CDD:276809	17/25 (68%)
		TPR 1	46..79		26/32 (81%)
		TPR repeat	47..74	CDD:276809	20/26 (77%)
		TPR 2	80..113		31/32 (97%)
		TPR repeat	82..108	CDD:276809	25/25 (100%)
		PEP_TPR_lipo	<90..271	CDD:274350	111/180 (62%)
		TPR repeat	113..143	CDD:276809	24/29 (83%)
		TPR 3	148..184		21/35 (60%)
		TPR repeat	148..173	CDD:276809	16/24 (67%)
		NARP1	187..698	CDD:403685	273/521 (52%)
		TPR 4	224..257		14/32 (44%)
		TPR 5	374..407		17/32 (53%)
		TPR repeat	378..402	CDD:276809	13/23 (57%)
		TPR repeat	407..437	CDD:276809	16/29 (55%)
		TPR 6	409..441		16/31 (52%)
		TPR repeat	442..467	CDD:276809	18/24 (75%)
		TPR 7	485..518		23/32 (72%)
		Interaction with HYPK. /evidence=ECO:0000269\|PubMed:20154145	500..866		168/390 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..642		26/74 (35%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	612..629		6/16 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159617
Domainoid	1	1.000	562	1.000	Domainoid score	I237
eggNOG	1	0.900	-	-		E1_KOG1156
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	917	1.000	Inparanoid score	I359
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53707
OrthoDB	1	1.010	-	-		D249768at33208
OrthoFinder	1	1.000	-	-		FOG0002033
OrthoInspector	1	1.000	-	-		otm41712
orthoMCL	1	0.900	-	-		OOG6_101670
Panther	1	1.100	-	-	O	PTHR22767
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4115
SonicParanoid	1	1.000	-	-		X1503
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800