DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Naa15-16 and NAA16

DIOPT Version :9

Sequence 1:	NP_001285439.1	Gene:	Naa15-16 / 32934	FlyBaseID:	FBgn0031020	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_078837.3	Gene:	NAA16 / 79612	HGNCID:	26164	Length:	864	Species:	Homo sapiens

Alignment Length:	850	Identity:	455/850 - (53%)
Similarity:	614/850 - (72%)	Gaps:	30/850 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LPPKEGALFRKLLKCYELKQYKNGLKLAKQILSNPKYMEHGETLAMKGLTLNGLGRREEAYKYVR 71
            |||||..||:::|||||.||||||||..|.||||||:.||||||||||||||.||::||||::||
Human     6 LPPKESNLFKRILKCYEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLGKKEEAYEFVR 70

  Fly    72 LGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKE 136
            .|||||::||||||||||||||||||||||||||||||.:|||||||:|||||||||||||||:|
Human    71 KGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRE 135

  Fly   137 TRHHLFTLRPSQHASWIGFAMSYHLLGDYDMANSILETFSQS-QTSIEAHDYRHSELLLYQNQIL 200
            ||:.|..|||:|.|||||:|::||||.|||||..:||.|.|: |......||.:|||:|||||::
Human   136 TRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQVPPNKIDYEYSELILYQNQVM 200

  Fly   201 IESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYYEQYI 265
            .|::.||::::|:..|:.||.|||.|.|..|::.:||.:.::|..:|::||.||.||..|||...
Human   201 READLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLIDRNAENWCYYEGLE 265

  Fly   266 AARQVTDSSAVVSIYRVFQEQYPRALCPRRLPLNIANGDEFRVVTDEYLRRGLRKGIPPLFVNVR 330
            .|.|::.....:.||....:|:|:|:.||||||.:..|:.||.:.|::||....||.||||..::
Human   266 KALQISTLEERLQIYEEISKQHPKAITPRRLPLTLVPGERFRELMDKFLRVNFSKGCPPLFTTLK 330

  Fly   331 TLHQIPERAAVIEELALQYFENLTRSGHFS-REDADAGIPVEPASALVWTALFLAQHYDYMRDTD 394
            :|:...|:.::|:||...|..:|.....|| .|:.:.    ||.:.|:|...|||||:|.:....
Human   331 SLYYNTEKVSIIQELVTNYEASLKTCDFFSPYENGEK----EPPTTLLWVQYFLAQHFDKLGQYS 391

  Fly   395 RALEYINVAIDHTPTLIELLITKGRIFKHAGDPVEAYVWLEEAQSMDTADRYINSKCAKYMLRAN 459
            .||:|||.||..|||||||...|.:|:||.|:..||..|::||||:|||||:|||||||||||||
Human   392 LALDYINAAIASTPTLIELFYMKAKIYKHIGNLKEAAKWMDEAQSLDTADRFINSKCAKYMLRAN 456

  Fly   460 MVQEAEEICAKFTREGVSAMDNLNEMQCMWFQTECALAYQRMGRWGESLKKCHEVERHFAEIVED 524
            |::||||:|:||||||.|||:||||||||||||||..||||:||:|::|||||||||||.||.:|
Human   457 MIKEAEEMCSKFTREGTSAMENLNEMQCMWFQTECISAYQRLGRYGDALKKCHEVERHFFEITDD 521

  Fly   525 QFDFHTYCMRKMTLRAYVGLLRLEDVLRQHPFYFKAAKCAIEVYIRLYDKPLKSETTIEEIDIEN 589
            ||||||||||||||||||.||||||:||:|.||||||:.|||:|::|||.||.:|:..:||:.||
Human   522 QFDFHTYCMRKMTLRAYVDLLRLEDILRRHAFYFKAARSAIEIYLKLYDNPLTNESKQQEINSEN 586

  Fly   590 LPPSELKKLRSKQRKAKKKAELESAQAAQAQVKREQHQKSKQQANQETDPDAPQL-DELVAEKLE 653
            |...||||:.||||:|:|||:||.   .:...:||:.||::::...|.:.:|..| :||:.||||
Human   587 LSAKELKKMLSKQRRAQKKAKLEE---ERKHAERERQQKNQKKKRDEEEEEASGLKEELIPEKLE 648

  Fly   654 RTDDPLDKAIEFLKPLQQLAKERIETHLLAFELYYRKNKLLLMLQCIRRARAVDASHPVIHSCII 718
            |.::||::|::||.||:.|..:.|:|||||||:|:||.|.|||||.::||.|:::::|.:|.|:|
Human   649 RVENPLEEAVKFLIPLKNLVADNIDTHLLAFEIYFRKGKFLLMLQSVKRAFAINSNNPWLHECLI 713

  Fly   719 RFVKSLTSAAKEQPFNEHVQQVLEKATKELIGSKTPQQLNDEFIAKHNASILHLYEGARSLYELD 783
            ||.||:::.:.   ..:.|.:||.:..:::...|..:..|::|:.::..|:.||..||:.:|.||
Human   714 RFSKSVSNHSN---LPDIVSKVLSQEMQKIFVKKDLESFNEDFLKRNATSLQHLLSGAKMMYFLD 775

  Fly   784 NSKKAAAIKLVTSFNLAKLRLEEA---------TKIYTALRDGDVFGECEAEAASYQQACHQRFQ 839
            .|::..||.:.|       ||:|.         .|:..||.||. ||.|.::...|:.|||....
Human   776 KSRQEKAIAIAT-------RLDETIKDKDVKTLIKVSEALLDGS-FGNCSSQYEEYRMACHNLLP 832

  Fly   840 YARIF 844
            :...|
Human   833 FTSAF 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naa15-16	NP_001285439.1	TPR repeat	13..39	CDD:276809	17/25 (68%)
		TPR repeat	48..75	CDD:276809	20/26 (77%)
		TPR repeat	83..109	CDD:276809	25/25 (100%)
		TPR repeat	114..144	CDD:276809	24/29 (83%)
		TPR repeat	149..173	CDD:276809	15/23 (65%)
		NARP1	187..703	CDD:289346	275/517 (53%)
		TPR repeat	410..440	CDD:276809	15/29 (52%)
		TPR repeat	445..470	CDD:276809	20/24 (83%)
NAA16	NP_078837.3	TPR repeat	13..38	CDD:276809	17/24 (71%)
		TPR 1	46..79		25/32 (78%)
		TPR_11	47..111	CDD:290150	54/63 (86%)
		TPR repeat	47..74	CDD:276809	20/26 (77%)
		TPR 2	80..113		30/32 (94%)
		TPR_11	82..145	CDD:290150	54/62 (87%)
		TPR repeat	82..108	CDD:276809	25/25 (100%)
		TPR_1	<87..113	CDD:278916	23/25 (92%)
		TPR repeat	113..143	CDD:276809	24/29 (83%)
		TPR 3	148..184		20/35 (57%)
		TPR repeat	148..173	CDD:276809	16/24 (67%)
		NARP1	187..698	CDD:289346	275/517 (53%)
		TPR 4	224..257		12/32 (38%)
		TPR 5	374..407		16/32 (50%)
		TPR repeat	378..402	CDD:276809	12/23 (52%)
		TPR repeat	407..437	CDD:276809	15/29 (52%)
		TPR 6	409..441		16/31 (52%)
		TPR repeat	442..467	CDD:276809	20/24 (83%)
		TPR 7	485..518		25/32 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..638		11/37 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159618
Domainoid	1	1.000	562	1.000	Domainoid score	I237
eggNOG	1	0.900	-	-		E1_KOG1156
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134838
Inparanoid	1	1.050	917	1.000	Inparanoid score	I359
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53707
OrthoDB	1	1.010	-	-		D249768at33208
OrthoFinder	1	1.000	-	-		FOG0002033
OrthoInspector	1	1.000	-	-		otm41712
orthoMCL	1	0.900	-	-		OOG6_101670
Panther	1	1.100	-	-	LDO	PTHR22767
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4115
SonicParanoid	1	1.000	-	-		X1503
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800