DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Naa15-16 and Naa16

DIOPT Version :9

Sequence 1:	NP_001285439.1	Gene:	Naa15-16 / 32934	FlyBaseID:	FBgn0031020	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	XP_003751565.1	Gene:	Naa16 / 686240	RGDID:	1584324	Length:	864	Species:	Rattus norvegicus

Alignment Length:	877	Identity:	459/877 - (52%)
Similarity:	616/877 - (70%)	Gaps:	36/877 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LPPKEGALFRKLLKCYELKQYKNGLKLAKQILSNPKYMEHGETLAMKGLTLNGLGRREEAYKYVR 71
            ||.||.|||:::|||||.||||||||..|.||||||:.:|||||||||||||.||:|||||::||
  Rat     6 LPAKESALFKRVLKCYEQKQYKNGLKFCKMILSNPKFADHGETLAMKGLTLNCLGKREEAYEFVR 70

  Fly    72 LGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKE 136
            .|||:|:|||||||||||||||||||||||||||||||.:|||||||:|||||||||||||||:|
  Rat    71 KGLRSDVRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRE 135

  Fly   137 TRHHLFTLRPSQHASWIGFAMSYHLLGDYDMANSILETFSQSQTSIEAHD--YRHSELLLYQNQI 199
            ||:.|..|||:|.|||||:|::||||.|||.|..:||.|.|:| .:..:.  |.:|||||||||:
  Rat   136 TRYQLLQLRPTQRASWIGYAIAYHLLKDYDTALKLLEEFRQTQ-QVPPNKIAYEYSELLLYQNQV 199

  Fly   200 LIESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYYEQY 264
            :.|:|..|::::|:..|:..|.|||.|.|..|::.:||.:.::|..:|::||..|.||..|||..
  Rat   200 MREANLFQESLEHIETYEKLICDKLLVEEIKGEMLLKLGRLKEASEVFKNLIDWNAENWCYYEGL 264

  Fly   265 IAARQVTDSSAVVSIYRVFQEQYPRALCPRRLPLNIANGDEFRVVTDEYLRRGLRKGIPPLFVNV 329
            ..|.|:......:.||....:|:|||:.|||||||...|.:|:.:.|::||....||.||||..:
  Rat   265 EKALQLRSLDERLQIYEEISKQHPRAVSPRRLPLNFVPGKKFQELMDKFLRPNFSKGCPPLFTTL 329

  Fly   330 RTLHQIPERAAVIEELALQYFENLTRSGHFS-REDADAGIPVEPASALVWTALFLAQHYDYMRDT 393
            ::|:...|:.::|:||...|..:|..:|.|| .|:.:.    ||.:.|:|...|||||:|.:...
  Rat   330 KSLYCNTEKVSIIQELVTNYEASLKMNGFFSPYENGEK----EPPTTLIWVQYFLAQHFDKLGQY 390

  Fly   394 DRALEYINVAIDHTPTLIELLITKGRIFKHAGDPVEAYVWLEEAQSMDTADRYINSKCAKYMLRA 458
            ..||||||..|..|||||||...|.:|:||.|:..||..|::||||:|||||:||||||||||||
  Rat   391 FLALEYINAVIASTPTLIELFYMKAKIYKHMGNLREAAQWMDEAQSLDTADRFINSKCAKYMLRA 455

  Fly   459 NMVQEAEEICAKFTREGVSAMDNLNEMQCMWFQTECALAYQRMGRWGESLKKCHEVERHFAEIVE 523
            ||::||||:|::|||||.|||:||||||||||:|||..||||:||:|::|||||||||||.||.:
  Rat   456 NMIKEAEEMCSRFTREGTSAMENLNEMQCMWFETECISAYQRLGRYGDALKKCHEVERHFVEITD 520

  Fly   524 DQFDFHTYCMRKMTLRAYVGLLRLEDVLRQHPFYFKAAKCAIEVYIRLYDKPLKSETTIEEIDIE 588
            |||||||||||:|||||||.||||||.||:|.||||||:.|||:|::|:|.||.|::..::||.|
  Rat   521 DQFDFHTYCMRRMTLRAYVDLLRLEDTLRRHTFYFKAARSAIEIYLKLHDNPLTSDSKQQDIDSE 585

  Fly   589 NLPPSELKKLRSKQRKAKKKAELESAQAAQAQVKREQHQKSKQQANQETDPDAPQLDELVAEKLE 653
            ||...||||:.||||:|:|||::|..:....:.:::::||.|::  :|.:..:...:||:.||||
  Rat   586 NLSAKELKKMLSKQRRAQKKAKVEEERKHTERERQQKNQKKKRE--EEEEVTSGHKEELIPEKLE 648

  Fly   654 RTDDPLDKAIEFLKPLQQLAKERIETHLLAFELYYRKNKLLLMLQCIRRARAVDASHPVIHSCII 718
            |.|:||::||:||.||:.||.:.|.|||||||:|:||.|.|||||.::||.|:|:::|.:|.|:|
  Rat   649 RVDNPLEEAIKFLTPLKTLAADNIYTHLLAFEIYFRKGKFLLMLQSVKRAFAIDSNNPWLHECLI 713

  Fly   719 RFVKSLTSAAKEQPFNEHVQQVLEKATKELIGSKTPQQLNDEFIAKHNA-SILHLYEGARSLYEL 782
            :|.||:::.:.   ..:.|..||.:..|::...|.....|::|: |||| |:.||..||:.:|.|
  Rat   714 KFSKSVSNHSN---LPDIVSTVLAQEMKKIFVDKDVHSFNEDFL-KHNATSLQHLLAGAKMMYFL 774

  Fly   783 DNSKKAAAIKLVTSFNLAKLRLEEA---------TKIYTALRDGDVFGECEAEAASYQQACHQRF 838
            |.|::..||...|       ||:|.         .|:..||:||. ||.|.::...|::.||..|
  Rat   775 DKSRQEKAIATAT-------RLDETIKNKNVKTLIKVSEALQDGS-FGNCSSQYEEYRKTCHNLF 831

  Fly   839 QYARIF----RNVEELEAQLQEKEAAKLRAEE 866
            .....|    .....|..:|......||...|
  Rat   832 PLTPAFLPAANEALGLSTELNHTAEHKLLTNE 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naa15-16	NP_001285439.1	TPR repeat	13..39	CDD:276809	18/25 (72%)
		TPR repeat	48..75	CDD:276809	21/26 (81%)
		TPR repeat	83..109	CDD:276809	25/25 (100%)
		TPR repeat	114..144	CDD:276809	24/29 (83%)
		TPR repeat	149..173	CDD:276809	14/23 (61%)
		NARP1	187..703	CDD:289346	271/516 (53%)
		TPR repeat	410..440	CDD:276809	15/29 (52%)
		TPR repeat	445..470	CDD:276809	20/24 (83%)
Naa16	XP_003751565.1	TPR repeat	12..38	CDD:276809	18/25 (72%)
		TPR_11	47..111	CDD:290150	55/63 (87%)
		TPR repeat	47..74	CDD:276809	21/26 (81%)
		TPR_11	82..145	CDD:290150	54/62 (87%)
		TPR repeat	82..108	CDD:276809	25/25 (100%)
		TPR_1	<87..113	CDD:278916	23/25 (92%)
		TPR repeat	113..143	CDD:276809	24/29 (83%)
		TPR repeat	148..173	CDD:276809	15/24 (63%)
		NARP1	187..698	CDD:289346	271/516 (53%)
		TPR repeat	378..402	CDD:276809	12/23 (52%)
		TPR repeat	407..437	CDD:276809	15/29 (52%)
		TPR repeat	442..467	CDD:276809	20/24 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353667
Domainoid	1	1.000	553	1.000	Domainoid score	I239
eggNOG	1	0.900	-	-		E1_KOG1156
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134838
Inparanoid	1	1.050	913	1.000	Inparanoid score	I343
OMA	1	1.010	-	-		QHG53707
OrthoDB	1	1.010	-	-		D249768at33208
OrthoFinder	1	1.000	-	-		FOG0002033
OrthoInspector	1	1.000	-	-		otm45841
orthoMCL	1	0.900	-	-		OOG6_101670
Panther	1	1.100	-	-	LDO	PTHR22767
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1503
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810