DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Naa15-16 and psidin

DIOPT Version :9

Sequence 1:	NP_001285439.1	Gene:	Naa15-16 / 32934	FlyBaseID:	FBgn0031020	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_650858.1	Gene:	psidin / 42389	FlyBaseID:	FBgn0243511	Length:	948	Species:	Drosophila melanogaster

Alignment Length:	959	Identity:	171/959 - (17%)
Similarity:	325/959 - (33%)	Gaps:	294/959 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EGALF-RKLLKCYELKQYKNGLKLAKQILSNPKYMEHGETL---AMKGLTLNGLGRREEAYKYVR 71
            :.||| |:|...|:..:..|..|..::  |.....:|...|   |:|||:|..|||.:|::..::
  Fly     8 DSALFERRLRPVYDNLEVGNNRKALQE--SEKLLRKHPNLLCARALKGLSLLRLGRYDESHGCLQ 70

  Fly    72 LGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKE 136
            ..............|.....|..::.|:.::.|::|:|....|.::|..|.:..:::.|.:..:.
  Fly    71 TVAEEKPTDDSTLQVLSFCYREMEQLDKIVELYQHAVKQNPGNEELLAHLFISHVRVEDYKAQQA 135

  Fly   137 TRHHLFTLRPSQHASWIGFAMSYHLLGDYDMANSILET----FSQSQTSIEAHDYR-----HSEL 192
            ....|:..:| ::|.:....:|....|.....:::.|.    ...:|..::.|...     ..|.
  Fly   136 VALQLYKAQP-KNAYYFWSVISVVFQGIRGPESALPEKRKIYLGLAQRMVDKHIKEGKMETEQEA 199

  Fly   193 LLYQNQILIESNRLQQAVDHLTKYQGQIVDKL---AVRETMGDLYIKLQQQEKAVPIFESLIRRN 254
            .||.: ||...|:.|:|.:.||   |::..||   |......:|..:|....:...:.:.|:..:
  Fly   200 FLYLH-ILKLQNKYQEAWEFLT---GELCAKLYPGAPVSMKFELLKELGNWRELNELLQQLLDAD 260

  Fly   255 PENVLYYEQYIAARQVTDSSAVVSIYRVFQEQYPRALCPRRLPLNIANGDEFRVV-TDEYLRRGL 318
            .:...:|::||.           |.:.:.          :..|..:.|||:..:. ..|:|:|.:
  Fly   261 RDRWDFYKEYIQ-----------SSFELL----------KLTPQGVENGDKDSLARCQEFLQRII 304

  Fly   319 ----RKGIPPLFVNVRTLH------QIPERAAV--IEELALQYFENLTRSGHFSREDADAGIPVE 371
                ||...|....:. ||      |:|....:  .:|:.::||.........:.:
  Fly   305 DSSERKKRGPYLARLE-LHQRMRAEQLPAEKLIGDFDEMVIEYFRLFGDKSCCTHD--------- 359

  Fly   372 PASALVWTALFLAQHYDYMRDTDRALEYINVAIDHTPTLIELLITKGRIFKHAGDPVEAYVWLEE 436
                   .||||.                :::::....|...|:
  Fly   360 -------IALFLP----------------SISMNQRQALASKLL--------------------- 380

  Fly   437 AQSMDTADRYINSKCAKYMLRANMVQEAEEICA-KFTREGVSAMDNLNEMQCMWFQTECALAYQR 500
                      :.|......|..|..|..:.:|| :.:|...|.|| |.....:.|.|...|.|:.
  Fly   381 ----------LESGVTSTSLPKNKEQLQKHLCALQISRMCGSHMD-LPADHLLAFYTALKLHYEH 434

  Fly   501 MGR--WGESL----------------KKCHEVERHFAEIVEDQFD--FHTYCMRKMTLRAYVGLL 545
             ||  :|:.|                ...:::.|.     |::.|  |...|:
  Fly   435 -GRTTFGKKLLATEMGPSDAYALLAANVMYDLSRR-----ENKSDHLFEALCL------------ 481

  Fly   546 RLEDVLRQHPFYFKAAKCAIEVYIRLYDKPLKSETTIEEIDIENLPPSELKKLRSKQRKAKKKAE 610
             |:.|||.....|.....::::| .|:...:.::...|.:||                   |:.:
  Fly   482 -LQYVLRNSTSNFHVKLLSLKIY-HLFGCQVGAQEMYEYLDI-------------------KQIQ 525

  Fly   611 LESAQAAQAQVKREQHQKSKQQANQETDPDAPQLDELVAEKLERTDDPLDKAIEFLKPLQQLAKE 675
            |:|......|:.                        .:..:.....:..|..::|   .....||
  Fly   526 LDSMGYVHCQLL------------------------ALGGRFSGNRNVYDATLKF---FTNSYKE 563

  Fly   676 RIETHLLAF---------ELYYRKNKLLLMLQCIRRARAVDASHPVIHSCIIRFVKSLTS--AAK 729
            |:|...|.:         |....|.:|...||.:  |.:|:|....:.||.....::|::  |..
  Fly   564 RLEYIALTYRFCTFSKMEEFMNFKERLTNSLQYV--ACSVEAQICDLVSCYGNITQNLSAYVAMS 626

  Fly   730 EQPFNEHVQQVLEKATKELIGSK---------------TPQQLNDEF------------IAKHNA 767
            .:|..:.:      |..||..::               ..::..:.|            :.:..|
  Fly   627 IEPAEDRI------AWHELSDNRDLGAIIRWDPLHEVDAAEERRESFDQEVEVLQVRSLMLRLFA 685

  Fly   768 SILHLYEGARSLYELDNSKKAAAIKLVTSFNLAKLRLEEATKIYTALRDGDVFGECEAEAASYQQ 832
            |.:.||.|| .|.:.....:.|.::|:.         |..|.::..||           ..:|:.
  Fly   686 SFIDLYHGA-GLKDSPAGAETATLELLR---------ESWTGLFQRLR-----------VMNYKP 729

  Fly   833 ACHQRF---------------QYARIFRNVEELEAQLQEKEAAKLRAEE 866
            .. |:|               .|.|.|.::.:|...|| ..:||| ||:
  Fly   730 LA-QKFLVNLLPTRLHLLLDMPYERFFDDLAQLVLDLQ-SGSAKL-AEQ 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naa15-16	NP_001285439.1	TPR repeat	13..39	CDD:276809	8/26 (31%)
		TPR repeat	48..75	CDD:276809	10/29 (34%)
		TPR repeat	83..109	CDD:276809	5/25 (20%)
		TPR repeat	114..144	CDD:276809	5/29 (17%)
		TPR repeat	149..173	CDD:276809	3/23 (13%)
		NARP1	187..703	CDD:289346	94/566 (17%)
		TPR repeat	410..440	CDD:276809	2/29 (7%)
		TPR repeat	445..470	CDD:276809	6/25 (24%)
psidin	NP_650858.1	TPR_12	42..108	CDD:290160	16/65 (25%)
		TPR repeat	48..74	CDD:276809	9/25 (36%)
		TPR repeat	79..109	CDD:276809	5/29 (17%)
		TPR repeat	114..142	CDD:276809	4/27 (15%)
		NatB_MDM20	264..642	CDD:286836	88/537 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470226
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22767
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030