DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Naa15-16 and SPBC418.02

DIOPT Version :9

Sequence 1:	NP_001285439.1	Gene:	Naa15-16 / 32934	FlyBaseID:	FBgn0031020	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_596495.1	Gene:	SPBC418.02 / 2540808	PomBaseID:	SPBC418.02	Length:	695	Species:	Schizosaccharomyces pombe

Alignment Length:	693	Identity:	168/693 - (24%)
Similarity:	296/693 - (42%)	Gaps:	81/693 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LPPKEGALFRKLLKCYELKQYKNGLKLAKQILSNPKYMEHGETLAMKGLTLNGLGRREEAYKYVR 71
            |..||..||.:.:..:|..||...||..:.:|.  |..:|.:::|:.||.|..|.....|.....
pombe     4 LSEKEAFLFDRSIDQFEKGQYSKSLKTIQSVLK--KKPKHPDSVALLGLNLCKLHDSRSALLKCG 66

  Fly    72 LGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKE 136
            .....|.:|..|||...::.|..|.|:.::|||:|||....:|..:..|.:.||.|:...:...:
pombe    67 YASSIDPKSQFCWHALAIVYRETKDYNNSLKCYQNALAISPNNESLWYDAAYLQAQLGLYQPLFD 131

  Fly   137 TRHHLFTLRPSQHASWIGFAMSYHLLGDYDMANSILETFSQSQTSIEAHDYRH---SELLLYQNQ 198
            ..:.|..|..|.....:.|.:|..|.|:|.      |:..|.|..|.:.:...   |.|:.:..:
pombe   132 NWNRLLQLDSSNLEYRLCFTLSAFLSGNYK------ESLEQIQYLISSCNLSPLVVSRLISFLPR 190

  Fly   199 IL--IESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYY 261
            |.  || |..|..::.|...|...::.........|...:.:..|:::.::..|:.:.|..:.|.
pombe   191 ICEHIE-NGSQTVLEILLMNQNSFLNNFNFEHIKADFAFRQKNYEESIYLYARLLIKFPNRLDYS 254

  Fly   262 EQYIAARQVTDSSAVVSIYRVFQEQYPRALCPRRLPLNIANGDEFRVVTDEYLRRG-------LR 319
            |:|:.           |::..::..      ...|.|.:...|.......|.|:.|       |.
pombe   255 EKYLN-----------SLWNFYKSG------GLALDLLLKRTDSLIKTFSEILQTGISVLIFLLS 302

  Fly   320 KGIPPLF-----VNVRTLHQIPERAAVIEELALQYFEN-------LTRSGHFSREDADAGIPVEP 372
            |.:...|     ::....|.||   :.|..|.:....|       :|...:|...|:...||...
pombe   303 KNLDYDFCLNHLISYSMHHFIP---SFISLLKIPLKTNDAFSKKLITMLSNFREGDSAKNIPTHK 364

  Fly   373 ASALVWTALFLAQHYDYMRDTDRALEYINVAIDHTPTLIELLITKGRIFKHAGDPVEAYVWLEEA 437
                :|....|...:..:.|.:.:..::|:|||||||..||.:.|.:||...|:..||....:.:
pombe   365 ----LWCTYCLCLAHYKLGDYEESNYWLNLAIDHTPTYPELFLAKAKIFLCMGEIEEALCSFKRS 425

  Fly   438 QSMDTADRYINSKCAKYMLRANMVQEAEEICAKFTREGVSAMDN-LNEMQCMWFQTECALAYQRM 501
            ..:|.:||.:.||.|||::|.:..:||..:.:||:|.....:.| |.|.:|:||..|...:..|.
pombe   426 VELDKSDRALASKYAKYLIRMDRNEEAYIVLSKFSRFRFGGVCNYLAETECVWFLVEDGESLLRQ 490

  Fly   502 GRWGESLKKCHEVERHFAEIVEDQFDFHTYCMRKMTLRAYVGLLRLEDVLRQHPFYFKAAKCAIE 566
            ..:|.:||:.|.:.:.:.:....:||:.|.|......:.||.|:...|.|.....|.:|...|:.
pombe   491 KLYGLALKRFHSIYQIYKKWSFLKFDYFTQCAEDGEFQEYVELVEWSDNLWSSTDYLRATLGALT 555

  Fly   567 VYIRLYDKPL-----KSETTIEEIDIENLPPSELKKLRSKQRKAKKKAELESAQAAQAQVKREQH 626
            :|:.|::...     |:|      :|.::  ||::::...:...||..:|:          :.:.
pombe   556 IYLLLFESKFNMYGNKAE------EISHM--SEVEQIAYAREDNKKIMKLQ----------KIEE 602

  Fly   627 QKSKQQANQETDPDAPQLDELVAEKLERTDDPLDKAIEFLKPL 669
            .|.|.....|::......::....||..|||||.:|:.||:|:
pombe   603 DKIKSYIPSESEEPLVIDEDYFGHKLLITDDPLTEAMRFLQPI 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naa15-16	NP_001285439.1	TPR repeat	13..39	CDD:276809	7/25 (28%)
		TPR repeat	48..75	CDD:276809	6/26 (23%)
		TPR repeat	83..109	CDD:276809	11/25 (44%)
		TPR repeat	114..144	CDD:276809	6/29 (21%)
		TPR repeat	149..173	CDD:276809	5/23 (22%)
		NARP1	187..703	CDD:289346	118/513 (23%)
		TPR repeat	410..440	CDD:276809	8/29 (28%)
		TPR repeat	445..470	CDD:276809	9/24 (38%)
SPBC418.02	NP_596495.1	TPR repeat	11..36	CDD:276809	7/24 (29%)
		TPR_11	47..107	CDD:290150	19/59 (32%)
		TPR repeat	47..70	CDD:276809	5/22 (23%)
		TPR repeat	75..105	CDD:276809	13/29 (45%)
		TPR_11	78..140	CDD:290150	18/61 (30%)
		TPR_2	79..109	CDD:285020	11/29 (38%)
		TPR repeat	110..138	CDD:276809	5/27 (19%)
		TPR repeat	144..168	CDD:276809	7/29 (24%)
		NARP1	<334..645	CDD:289346	86/332 (26%)
		TPR repeat	369..393	CDD:276809	4/23 (17%)
		TPR repeat	398..428	CDD:276809	8/29 (28%)
		TPR repeat	433..458	CDD:276809	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1156
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53707
OrthoFinder	1	1.000	-	-		FOG0002033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920