DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Naa15-16 and naa15

DIOPT Version :9

Sequence 1:	NP_001285439.1	Gene:	Naa15-16 / 32934	FlyBaseID:	FBgn0031020	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_588160.1	Gene:	naa15 / 2539338	PomBaseID:	SPCC338.07c	Length:	729	Species:	Schizosaccharomyces pombe

Alignment Length:	764	Identity:	261/764 - (34%)
Similarity:	424/764 - (55%)	Gaps:	61/764 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LPPKEGALFRKLLKCYELKQYKNGLKLAKQILSNPKYMEHGETLAMKGLTLNGLGRREEAYKYVR 71
            |.|||..|||..|||||.||||.|||..:.:|.  ::.||||:||:||:.|:.||..:|.|..||
pombe     6 LSPKEITLFRTALKCYETKQYKKGLKAIEPLLE--RHPEHGESLAIKGILLHSLGNTKEGYDNVR 68

  Fly    72 LGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKE 136
            ||||||:.|.||||::||:.|:||.|.:|.|||.||.|.||:|..:|:||:|||.|:|..:...:
pombe    69 LGLRNDVGSGVCWHIFGLISRADKDYVQAAKCYINAHKLEKNNSSLLRDLALLQSQLRQYKALAD 133

  Fly   137 TRHHLFTLRPSQHASWIGFAMSYHLLGDYDMANSILETF-SQSQTSIEAHDYRHSELLLYQNQIL 200
            ||:.|....|...|:|...|::..|.|:|..|..|::.| |.....:.......||.:|:.|.::
pombe   134 TRNALLQDNPGVRANWSALAVAQFLRGEYASAYKIVDAFESTINQGVPVDTQEESEAMLFMNLVI 198

  Fly   201 IESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYYEQY- 264
            ::.:.::.|..||...:.:::|::|..||..:..:.|.:.|:|......|:.|||:|..||...
pombe   199 LKKDGVEDAYKHLLSIEKKVLDRVAFLETRAEYELYLSKMEEAKSTIYLLLDRNPDNHQYYYNLQ 263

  Fly   265 ------IAARQVTDSSAVVSIYRVFQEQYPRALCPRRLPLNIANGDEFRVVTDEYLRRGLRKGIP 323
                  .|:.:|.||:..:::|....::||::.||.||||....||||....|.|||:.|::|||
pombe   264 RAYGYEDASGKVLDSAEWLNLYSQLAKRYPKSECPTRLPLEKLEGDEFLTHVDLYLRKKLKRGIP 328

  Fly   324 PLFVNVRTLHQIPERAAVIEELALQYFENLTRSGHFSREDADAGIPVEPASALVWTALFLAQHYD 388
            .:||:|::|::..::..|:|:|..:|..:|:.:..||.:|.::  .:|..:.|:||..|||||:|
pombe   329 SVFVDVKSLYKDTKKCKVVEDLVSKYASSLSTTNKFSEDDDNS--QIEIPTTLLWTYYFLAQHFD 391

  Fly   389 YMRDTDRALEYINVAIDHTPTLIELLITKGRIFKHAGDPVEAYVWLEEAQSMDTADRYINSKCAK 453
            ::.:.::|.:|:::||||||||:||.:||.||.||.|:...|...::.|:.:|..||:||.||||
pombe   392 HVGELEKAEKYVDLAIDHTPTLVELFMTKARISKHKGELQTAMEIMDHARKLDLQDRFINGKCAK 456

  Fly   454 YMLRANMVQEAEEICAKFTR-EGV-SAMDNLNEMQCMWFQTECALAYQRMGRWGESLKKCHEVER 516
            ||||.:..:.|.:..:.||| |.| .|:.:|.:|||:|:..|...::.|..::..:||:...|.:
pombe   457 YMLRNDENELAAKTVSLFTRNEAVGGAVGDLADMQCLWYMLEDGKSFARQKKFALALKRFSTVFK 521

  Fly   517 HFAEIVEDQFDFHTYCMRKMTLRAYVGLLRLEDVLRQHPFYFKAAKCAIEVYIRLYDKPLKSETT 581
            .|....:||||||.:..||.:||.|:.|:..||.:...|.:.:||:.:||:|..|:|.|. ::.:
pombe   522 IFDTWADDQFDFHFFAFRKGSLRTYLDLMSWEDSVYDDPSFREAAQGSIEIYFALFDLPF-AKYS 585

  Fly   582 IEEIDIENLPPSELKKLRSKQRKAKKKAELESAQAAQAQVKREQHQKSKQQANQETDPDAPQLDE 646
            .:..|.|.|...|:.:...|:...|.|.:|........::|.....::|.:.......|    ::
pombe   586 PKLPDFEKLSSGEINEEEEKKIYKKLKKDLSKRLERAEKLKEADKSRAKSEDGMPVKYD----ED 646

  Fly   647 LVAEKLERTDDPLDKAIEFLKPLQQLAKERIETHLLAFELYYRKNKLLLMLQCIRRARAVDASHP 711
            .:.|.|..|.:||.:|.:.|:.|.....:....::||.:||.|
pombe   647 PLGENLVATSEPLKEAQKCLEKLLPYGDKNPSAYILAAQLYTR---------------------- 689

  Fly   712 VIHSCIIRFVKSLTSAAKEQPFNEHVQQVLEKATKELIGSKTPQQLNDE 760
                     :|:..:|:|          .||:| |.::|...|..::.|
pombe   690 ---------LKNFDTASK----------YLEQA-KVILGQNDPTVISTE 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naa15-16	NP_001285439.1	TPR repeat	13..39	CDD:276809	15/25 (60%)
		TPR repeat	48..75	CDD:276809	14/26 (54%)
		TPR repeat	83..109	CDD:276809	15/25 (60%)
		TPR repeat	114..144	CDD:276809	12/29 (41%)
		TPR repeat	149..173	CDD:276809	8/23 (35%)
		NARP1	187..703	CDD:289346	167/524 (32%)
		TPR repeat	410..440	CDD:276809	12/29 (41%)
		TPR repeat	445..470	CDD:276809	12/24 (50%)
naa15	NP_588160.1	TPR repeat	12..38	CDD:276809	15/25 (60%)
		TPR repeat	45..72	CDD:276809	14/26 (54%)
		TPR repeat	80..106	CDD:276809	15/25 (60%)
		TPR repeat	111..140	CDD:276809	12/28 (43%)
		NARP1	186..703	CDD:289346	172/564 (30%)
		TPR repeat	677..703	CDD:276809	10/66 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	294	1.000	Domainoid score	I270
eggNOG	1	0.900	-	-		E1_KOG1156
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134838
Inparanoid	1	1.050	450	1.000	Inparanoid score	I296
OMA	1	1.010	-	-		QHG53707
OrthoFinder	1	1.000	-	-		FOG0002033
OrthoInspector	1	1.000	-	-		oto101618
orthoMCL	1	0.900	-	-		OOG6_101670
Panther	1	1.100	-	-	LDO	PTHR22767
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4115
SonicParanoid	1	1.000	-	-		X1503
TreeFam	1	0.960	-	-
	14	13.860