DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Naa15-16 and hpo-29

DIOPT Version :9

Sequence 1:	NP_001285439.1	Gene:	Naa15-16 / 32934	FlyBaseID:	FBgn0031020	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_497180.3	Gene:	hpo-29 / 175189	WormBaseID:	WBGene00021754	Length:	852	Species:	Caenorhabditis elegans

Alignment Length:	826	Identity:	327/826 - (39%)
Similarity:	510/826 - (61%)	Gaps:	33/826 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSDPLPPKEGALFRKLLKCYELKQYKNGLKLAKQILSNPKYMEHGETLAMKGLTLNGLGRREEAY 67
            ||.|||.||...|:|::|.||.||||.|||.|::||::|.:.|||||||||||.||.:|:.:||.
Worm     9 SSQPLPAKELGYFKKIVKSYEQKQYKAGLKFAQKILTSPGFAEHGETLAMKGLILNCMGKLQEAQ 73

  Fly    68 KYVRLGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLE 132
            ..||.||.:||||:|||||:||:|:::||||||||.|:.||..||||||||:|||||||.:||.:
Worm    74 DCVRRGLVSDLRSYVCWHVFGLIQKTEKKYDEAIKAYKRALMLEKDNLQILRDLSLLQIHIRDYD 138

  Fly   133 GYKETRHHLFTLRPSQHASWIGFAMSYHLLGDYDMANSILETFSQSQTSIEAHDYRHSELLLYQN 197
            ||..:::.|..||.:|..||:|:.:::|||.::::|..|:..:.::.|. ..:|:..|||:||||
Worm   139 GYLSSKYELLQLRQTQRVSWLGYIVAHHLLKEHNLALGIMAEYIKNNTP-SGYDFEFSELILYQN 202

  Fly   198 QILIESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYYE 262
            .|:.|:.....|:..|.:....||||:|..||..:|.:.|:|.::|..::.:||.|||:::.||:
Worm   203 LIMREAGLPDVALQKLEENSTHIVDKVAYMETRANLLMDLEQPKQAENVWRALIERNPDSLEYYD 267

  Fly   263 QYIAARQVTDS-SAVVSIYRVFQEQYPRALCPRRLPLNIANGDEFRVVTDEYLRRGLRKGIPPLF 326
            .......:.|| .|.:::.....|::.||..||||.|.:..|:|.|....|::...||||.|.||
Worm   268 MLEKCMGIKDSPKAQLAMLDGLAEKFKRAAAPRRLALYLVEGEELRRRLHEWMIPMLRKGAPSLF 332

  Fly   327 VNVRTLHQIPERAAVIEELALQYFENLTRSGH--FSREDADAGIPVEPASALVWTALFLAQHYDY 389
            .::..|::.|::.||||.|..:|.:.:...|:  .|.:..|.  ..||.:..:|..:..:.|:|.
Worm   333 ASLVPLYKYPQKQAVIESLITEYVKKMDDEGYGNVSLDGKDQ--ECEPPTTALWLYVLASHHFDR 395

  Fly   390 MRDTDRALEYINVAIDHTPTLIELLITKGRIFKHAGDPVEAYVWLEEAQSMDTADRYINSKCAKY 454
            ...|..||.||..||.||||::|..:.|.||:|||||..||..|:|||||:||||||||.||.||
Worm   396 CGMTQLALNYIERAIQHTPTVVENYMLKARIYKHAGDYDEAARWMEEAQSLDTADRYINGKCGKY 460

  Fly   455 MLRANMVQEAEEICAKFTREGVSAMDNLNEMQCMWFQTECALAYQRMGRWGESLKKCHEVERHFA 519
            :|||....||.::.|||||||.:|..:|.:|||||::.|...|::.:.::||:|:|.|.::.||.
Worm   461 LLRAKRSDEANKMLAKFTREGENAASHLTDMQCMWYELESGRAFRSVNKYGEALRKAHHIDFHFN 525

  Fly   520 EIVEDQFDFHTYCMRKMTLRAYVGLLRLEDVLRQHPFYFKAAKCAIEVYIRLYDKP--LKSETTI 582
            ..:|||:||||||:|||||.:|:.|||:.|.||...:|::.||.||::|:|:.|:|  :...:.:
Worm   526 TWIEDQYDFHTYCLRKMTLCSYIRLLRMCDKLRDADYYYQGAKLAIKIYLRMIDRPDDMNEHSAL 590

  Fly   583 EEIDIENLPPSELKKLRSKQRKAKKKAELESAQAAQAQVKREQHQKSKQQANQETDPDAPQLDEL 647
            .:   |.:...|:||::   :|.||:.||        |.:.|:.:|.|:| .:|.....||:|
Worm   591 IK---EGMTDQEIKKMK---KKLKKQKEL--------QEEEEKKKKDKEQ-KEEGLQRGPQID-- 638

  Fly   648 VAEKLERTDDPLDKAIEFLKPLQQLAKERIETHLLAFELYYRKNKLLLMLQCIRRARAVDASHPV 712
             ||.|.:|:|||.:|.:|...:.....:::..:.|..|:|.||.|:||.|:|:......:.:||:
Worm   639 -AEALLKTEDPLGEAAKFCHNIHTFGTQKVTGYALCAEVYRRKGKVLLALKCLNEGEDREPTHPL 702

  Fly   713 IHSCIIRFVKSLTSAAKEQPFNEHVQQVLEKATKELIGS-KTPQQLNDEFIAKHNASILHLYEGA 776
            :|   ::.||.|....|.: .:..|::..::..|.:.|: :...:||::|..:|.....|....|
Worm   703 LH---VQKVKFLAYWPKCE-LSGLVKETADELMKCVYGAERDAAELNEKFKIEHQHDFAHRLAYA 763

  Fly   777 RSLYELDNSKKAAAIKLVTSFNLAKLRLEEATKIYTALRDGDVFGE 822
            .:.|.:|:|....: .::.|...:|:. ..:.|:...|:||..:|:
Worm   764 EAQYSIDSSTNLIS-WILKSIEDSKVN-GRSLKMMIKLKDGIEYGK 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naa15-16	NP_001285439.1	TPR repeat	13..39	CDD:276809	14/25 (56%)
		TPR repeat	48..75	CDD:276809	16/26 (62%)
		TPR repeat	83..109	CDD:276809	17/25 (68%)
		TPR repeat	114..144	CDD:276809	17/29 (59%)
		TPR repeat	149..173	CDD:276809	8/23 (35%)
		NARP1	187..703	CDD:289346	202/520 (39%)
		TPR repeat	410..440	CDD:276809	16/29 (55%)
		TPR repeat	445..470	CDD:276809	13/24 (54%)
hpo-29	NP_497180.3	TPR_11	54..118	CDD:290150	40/63 (63%)
		TPR repeat	54..81	CDD:276809	16/26 (62%)
		TPR repeat	86..116	CDD:276809	20/29 (69%)
		NARP1	192..692	CDD:289346	202/519 (39%)
		TPR repeat	385..411	CDD:276809	8/25 (32%)
		TPR repeat	416..446	CDD:276809	16/29 (55%)
		TPR repeat	451..476	CDD:276809	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167160
Domainoid	1	1.000	364	1.000	Domainoid score	I491
eggNOG	1	0.900	-	-		E1_KOG1156
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134838
Inparanoid	1	1.050	588	1.000	Inparanoid score	I542
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53707
OrthoDB	1	1.010	-	-		D249768at33208
OrthoFinder	1	1.000	-	-		FOG0002033
OrthoInspector	1	1.000	-	-		oto17966
orthoMCL	1	0.900	-	-		OOG6_101670
Panther	1	1.100	-	-	LDO	PTHR22767
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4115
SonicParanoid	1	1.000	-	-		X1503
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840