DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Naa15-16 and naa16

DIOPT Version :9

Sequence 1:	NP_001285439.1	Gene:	Naa15-16 / 32934	FlyBaseID:	FBgn0031020	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	XP_004911890.2	Gene:	naa16 / 100486426	XenbaseID:	XB-GENE-1013076	Length:	867	Species:	Xenopus tropicalis

Alignment Length:	843	Identity:	448/843 - (53%)
Similarity:	603/843 - (71%)	Gaps:	14/843 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LPPKEGALFRKLLKCYELKQYKNGLKLAKQILSNPKYMEHGETLAMKGLTLNGLGRREEAYKYVR 71
            ||.||..||:::|||||.||||||||..|.|||||::.||||||||||||||.||::||||::||
Frog     6 LPAKESNLFKRILKCYEQKQYKNGLKFCKMILSNPRFSEHGETLAMKGLTLNCLGKKEEAYEFVR 70

  Fly    72 LGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKE 136
            .|||||::||||||||||||||||||||||||||||||.:|||||||:|||||||||||||||:|
Frog    71 KGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRE 135

  Fly   137 TRHHLFTLRPSQHASWIGFAMSYHLLGDYDMANSILETFSQS-QTSIEAHDYRHSELLLYQNQIL 200
            ||:.|..|||:|.|||||:|::||||.||:||..:||.|.:: |......||.:|||:|||||::
Frog   136 TRYQLLQLRPTQRASWIGYAIAYHLLKDYEMALKLLEEFRKTQQVPPNKIDYEYSELILYQNQVM 200

  Fly   201 IESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYYEQYI 265
            .|:|..|:::||:..|:.||.|||.|.|..|::::||.:.::|..|:.:||.|||||..|||...
Frog   201 REANLCQESLDHIETYEKQICDKLQVEEIRGEMFLKLNRLKEASVIYRALIDRNPENWKYYENLE 265

  Fly   266 AARQVTDSSA--VVSIYRVFQEQYPRALCPRRLPLNIANGDEFRVVTDEYLRRGLRKGIPPLFVN 328
            .|.:...::.  .:.||....:::|:|:.|||||||..:|::||.:...:||....||.||||..
Frog   266 KACKPAPATVEEKLQIYEEINKRHPKAVSPRRLPLNFVSGEKFRDLISRFLRVNFSKGCPPLFTT 330

  Fly   329 VRTLHQIPERAAVIEELALQYFENLTRSGHFSREDADAGIPVEPASALVWTALFLAQHYDYMRDT 393
            :::|:...|:...|:|:...:..:|.....||.:|..   ..||.:.|:|...|||||:|.:...
Frog   331 LKSLYGNSEKVLAIQEIVTGFETSLKTCNMFSVDDNG---EKEPPTTLLWVRYFLAQHFDKLGQW 392

  Fly   394 DRALEYINVAIDHTPTLIELLITKGRIFKHAGDPVEAYVWLEEAQSMDTADRYINSKCAKYMLRA 458
            ..||:.||.||..|||||||...|.:|:||.|:..||..|::|:||:|||||:|||||||||:||
Frog   393 SLALDRINSAIASTPTLIELFYMKAKIYKHIGNLKEAAKWMDESQSLDTADRFINSKCAKYMIRA 457

  Fly   459 NMVQEAEEICAKFTREGVSAMDNLNEMQCMWFQTECALAYQRMGRWGESLKKCHEVERHFAEIVE 523
            |||:||||:|:||||||..||:|||||||||||||||.|:||.|::||:||||||:||||.||.:
Frog   458 NMVKEAEEMCSKFTREGTPAMENLNEMQCMWFQTECARAFQRQGKYGEALKKCHEIERHFFEITD 522

  Fly   524 DQFDFHTYCMRKMTLRAYVGLLRLEDVLRQHPFYFKAAKCAIEVYIRLYDKPLKSETTIEEIDIE 588
            |||||||||||||||||||.|||||||||||.||||||:.||.:|::|::.||.:|...:|::.|
Frog   523 DQFDFHTYCMRKMTLRAYVDLLRLEDVLRQHEFYFKAAETAIGIYLKLHENPLTNENKEQEVNSE 587

  Fly   589 NLPPSELKKLRSKQRKAKKKAELESAQAAQAQVKREQHQKSKQQANQETDPDAPQLDELVAEKLE 653
            ||...||||:.||||:|:|||:||. :...|:.:|:|..:.|::..:|.:...|: :|||.||||
Frog   588 NLSAKELKKVLSKQRRAQKKAKLEE-ERKHAERERQQKNQKKKRDEEEEETSGPK-EELVPEKLE 650

  Fly   654 RTDDPLDKAIEFLKPLQQLAKERIETHLLAFELYYRKNKLLLMLQCIRRARAVDASHPVIHSCII 718
            |.|:||::||:||.||:.||..:|.|||||||:|::|.|.|||||.|:||.::|..:|.:|.|:|
Frog   651 RVDNPLEEAIKFLTPLKSLAANKIRTHLLAFEIYFKKGKFLLMLQSIKRAVSIDPHNPWLHECLI 715

  Fly   719 RFVKSLTSAAKEQPFNEHVQQVLEKATKELIGSKTPQQLNDEFIAKHNASILHLYEGARSLYELD 783
            ||.|:::..:.   ..|.|.:||.:..|.:..:|.....|:||:..::.|||||..||:.:|.||
Frog   716 RFSKAVSDHSN---LPEIVNKVLMQEMKSIFTNKNMNSFNEEFLRHNSTSILHLLSGAKMMYYLD 777

  Fly   784 NSKKAAAIKLVTSFN--LAKLRLEEATKIYTALRDGDVFGECEAEAASYQQACHQRFQYARIF 844
            .|::..||.:.:..:  |....::..|.:..||.||. ||.|..:...|:.|||:.|.....|
Frog   778 KSRQEKAIAIASKLDDTLIDKNVQSLTSVLDALLDGS-FGSCNTQYEEYRTACHKLFPLTPAF 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naa15-16	NP_001285439.1	TPR repeat	13..39	CDD:276809	17/25 (68%)
		TPR repeat	48..75	CDD:276809	20/26 (77%)
		TPR repeat	83..109	CDD:276809	25/25 (100%)
		TPR repeat	114..144	CDD:276809	24/29 (83%)
		TPR repeat	149..173	CDD:276809	14/23 (61%)
		NARP1	187..703	CDD:289346	270/517 (52%)
		TPR repeat	410..440	CDD:276809	14/29 (48%)
		TPR repeat	445..470	CDD:276809	20/24 (83%)
naa16	XP_004911890.2	TPR repeat	13..38	CDD:276809	17/24 (71%)
		PEP_TPR_lipo	39..>257	CDD:274350	140/217 (65%)
		TPR repeat	47..74	CDD:276809	20/26 (77%)
		TPR repeat	82..108	CDD:276809	25/25 (100%)
		TPR repeat	113..143	CDD:276809	24/29 (83%)
		TPR repeat	148..173	CDD:276809	15/24 (63%)
		NARP1	187..700	CDD:403685	270/517 (52%)
		TPR repeat	378..404	CDD:276809	11/25 (44%)
		TPR repeat	409..439	CDD:276809	14/29 (48%)
		TPR repeat	444..469	CDD:276809	20/24 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	554	1.000	Domainoid score	I243
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134838
Inparanoid	1	1.050	916	1.000	Inparanoid score	I360
OMA	1	1.010	-	-		QHG53707
OrthoDB	1	1.010	-	-		D249768at33208
OrthoFinder	1	1.000	-	-		FOG0002033
OrthoInspector	1	1.000	-	-		otm48934
Panther	1	1.100	-	-	LDO	PTHR22767
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4115
SonicParanoid	1	1.000	-	-		X1503
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110