Protein Alignment CG32533 and DHX57

DIOPT Version :10

• Sequence 1: NP_728244.1
• Gene: CG32533 / 32933
• FlyBaseID: FBgn0052533
• Length: 1139
• Species: Drosophila melanogaster
• Sequence 2: NP_945314.1
• Gene: DHX57 / 90957
• HGNCID: 20086
• Length: 1386
• Species: Homo sapiens
• Alignment Length: 937
• Identity: 255/937 - (27%)
• Similarity: 419/937 - (44%)
• Gaps: 221/937 - (23%)

  Fly   127 FRQTEKFQRIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYR-- 189
            ||..:..::.:.:.|.:::||....|:.:...|...:||:::|.|||||:||:||::.|....
Human   525 FRMKQASRQFQSILQERQSLPAWEERETILNLLRKHQVVVISGMTGCGKTTQIPQFILDDSLNGP 589

  Fly   190 -----SIACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLA 249
                 :|.||||||::.:|:.:|||.|..:..|..|.:|||.|..::..|.:|:.|.|:|||:|.
Human   590 PEKVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLE 654

  Fly   250 VAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGEEGARL 314
            ....|.....:|:||:|||....||||.|.|.::..||.|::||||||:|.|||..||  ....:
Human   655 GDTALQGVSHIIVDEVHERTEESDFLLLVLKDIVSQRPGLQVILMSATLNAELFSDYF--NSCPV 717

  Fly   315 VQVPGRLFPIK----------LRYL----PPPALELKAGQATSKRSQRNRI-------------- 351
            :.:|||.||:.          .||:    .|....:|.......:::|||.
Human   718 ITIPGRTFPVDQFFLEDAIAVTRYVLQDGSPYMRSMKQISKEKLKARRNRTAFEEVEEDLRLSLH 782

  Fly   352 --------DPAP-------------------FVQVLSLID--------------------QQYPT 369
                    |..|                   .::.:|::|                    ..||.
Human   783 LQDQDSVKDAVPDQQLDFKQLLARYKGVSKSVIKTMSIMDFEKVNLELIEALLEWIVDGKHSYPP 847

  Fly   370 SERGDVLIFVSGVNEIESVVEAVHEYA----TEQTHWLVLPLHSGQAIADQSKVFDYAPEGMRKC 430
               |.:|:|:.|:.||:.:.|.:...:    ......::.||||..:..:|..||...|.|:.|.
Human   848 ---GAILVFLPGLAEIKMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPAGVTKI 909

  Fly   431 IVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCF 495
            |:||||||||:|:|.|.:|:||||:||..:||:...:.|::.:||:::|.||||||||...||||
Human   910 IISTNIAETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCF 974

  Fly   496 RLYTAEQYN-AFEAYPTPEIYRVPLDTM-----LLQMVSM-GLPDVRAFPFIEAPETERIEQTIL 553
            .|:|:..|| .......|||.||||:.:     :|:|.|. .|..|.: ..||.|.|:.:..:.:
Human   975 HLFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSAHNLQSVFS-RLIEPPHTDSLRASKI 1038

  Fly   554 ALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHT 618
            .|:...||:.:|::||||..||:|||::.|||::|.||:|..::..||:||.|:.::|..:....
Human  1039 RLRDLGALTPDERLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDK 1103

  Fly   619 DQRCVRERESLESDHGDLFTLVRLYNVWVQLKMRRDGTR---QWCRRLGIEEQRFYEVTKLRQQF 680
            .:...:::......:.|...|::.|..| ||. .::|.|   .:||:..:..:...|:..|::||
Human  1104 KEEANQKKLEFAFANSDYLALLQAYKGW-QLS-TKEGVRASYNYCRQNFLSGRVLQEMASLKRQF 1166

  Fly   681 QRILESCGMVVASDSDSQLTSAERATRHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEE 745
            ..:|...|.                .|.|                .|.|::.|::.|
Human  1167 TELLSDIGF----------------AREG----------------LRAREIEKRAQG-------- 1191

  Fly   746 QEEAQGDDMRDVDFRLRFDPRQLALLERSSRLDRHSVVVLLKLLLGSGFYPQL----AISDEFNY 806
                 ||.:.|....           |.:|..:...   |:..:|.:..||.:    :...:|..
Human  1192 -----GDGVLDATGE-----------EANSNAENPK---LISAMLCAALYPNVVQVKSPEGKFQK 1237

  Fly   807 CKGGGQQFFHTRLKPFVLQHPNSQFAKHFELLKLTESDLLPKPDFYTPKLPLSKRHQL------- 864
            ...|.     .|::|                 |..|...:.|.|.|....|.|..:|:
Human  1238 TSTGA-----VRMQP-----------------KSAELKFVTKNDGYVHIHPSSVNYQVRHFDSPY 1280

  Fly   865 LCYQSLLETAKPYLINCIRLPAAQTLLLF------------SFAIDTNAGITQIACDGWLGLDLP 917
            |.|...::|::.::.:| .:.:...|:||            .|.:..:        |||:.. :.
Human  1281 LLYHEKIKTSRVFIRDC-SMVSVYPLVLFGGGQVNVQLQRGEFVVSLD--------DGWIRF-VA 1335

  Fly   918 MPGSGMELLRRAIELRRRWSRLLYDKL 944
            ......||::   |||....:||.||:
Human  1336 ASHQVAELVK---ELRCELDQLLQDKI 1359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_728244.1	HrpA	145..>619	CDD:441249	189/566 (33%)
		OB_NTP_bind	792..897	CDD:400182	22/127 (17%)
DHX57	NP_945314.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..106
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..147
		UBA_DHX57	181..218	CDD:270502
		RWD_DHX57	242..425	CDD:467661
		zf_CCCH_4	305..323	CDD:465719
		HrpA	543..>1170	CDD:441249	203/634 (32%)
		DEVH box	668..671		2/2 (100%)
		OB_NTP_bind	1213..1310	CDD:400182	22/119 (18%)