DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32533 and PRP22

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_010929.3	Gene:	PRP22 / 856732	SGDID:	S000000815	Length:	1145	Species:	Saccharomyces cerevisiae

Alignment Length:	782	Identity:	211/782 - (26%)
Similarity:	368/782 - (47%)	Gaps:	129/782 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SRIKKKA--------------------DEHASSRRRTQINLIEFSFLDHKAELVGLLQAKSRQVG 46
            ::||::|                    |::...:....||.   |:|..|.:...::...:.:|.
Yeast   284 NKIKRRALTSPERWEIRQLIASGAASIDDYPELKDEIPINT---SYLTAKRDDGSIVNGNTEKVD 345

  Fly    47 RSLVE-------------NEADFWKFV--------GKYEAMMRSTGQPVLPPRLAEAELSSMQPY 90
            ..|.|             |..|..||:        .|||.           |::.:.....|...
Yeast   346 SKLEEQQRDETDEIDVELNTDDGPKFLKDQQVKGAKKYEM-----------PKITKVPRGFMNRS 399

  Fly    91 ----------HRSKHLALRLDADELL-------------QEARDQMQSQFRHILLVYLDFRQTEK 132
                      ||.:.|..:.:.::.:             :::|:::| ..::.|:| .::.:...
Yeast   400 AINGSNAIRDHREEKLRKKREIEQQIRKQQSFDDPTKNKKDSRNEIQ-MLKNQLIV-TEWEKNRM 462

  Fly   133 FQRIRKLRQT-------QRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFG--- 187
            .:.|...::|       ::.||:...|.:|.:|:..::.:::.|:||.||:||:.|||.:.|
Yeast   463 NESISYGKRTSLPISAQRQTLPVYAMRSELIQAVRDNQFLVIVGETGSGKTTQITQYLDEEGFSN 527

  Fly   188 YRSIACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAA 252
            |..|.||||||:|.||:.||||.|:....|..|.:.||||......|.|.::|:|:|.|:..:..
Yeast   528 YGMIGCTQPRRVAAVSVAKRVAEEVGCKVGHDVGYTIRFEDVTGPDTRIKYMTDGMLQREALLDP 592

  Fly   253 NLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGEEGARLVQV 317
            .:.:|..::|||.|||.:..|.|..:.|.....||:||:|:.|||:|...|..||  ....::.:
Yeast   593 EMSKYSVIMLDEAHERTVATDVLFALLKKAAIKRPELKVIVTSATLNSAKFSEYF--LNCPIINI 655

  Fly   318 PGRLFPIKLRYLPPPALELKAGQATSKRSQRNRIDPAPFVQVLSLIDQQYPTSERGDVLIFVSGV 382
            ||:.||:::.|              |:..|.:.|:.|     |..:...:.....||:|:|::|.
Yeast   656 PGKTFPVEVLY--------------SQTPQMDYIEAA-----LDCVIDIHINEGPGDILVFLTGQ 701

  Fly   383 NEIESVVEAVHE----YATEQTHWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTV 443
            .||:|..|.:::    ........|:||::|......|||:|:..|:|.||.:.:|||||||:|:
Yeast   702 EEIDSCCEILYDRVKTLGDSIGELLILPVYSALPSEIQSKIFEPTPKGSRKVVFATNIAETSITI 766

  Fly   444 DGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQ-YNAFE 507
            ||:.:|||.|..|...::|....::|....:|::.|:||||||||||||.|:||||... ||...
Yeast   767 DGIYYVVDPGFAKINIYNARAGIEQLIVSPISQAQANQRKGRAGRTGPGKCYRLYTESAFYNEML 831

  Fly   508 AYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCALSVEEKITPLGR 572
            ....|||.|..|...:|.:.:||:.|:..|.|::.|....:...:..|....:|..|.|:|.||:
Yeast   832 ENTVPEIQRQNLSHTILMLKAMGINDLLKFDFMDPPPKNLMLNALTELYHLQSLDDEGKLTNLGK 896

  Fly   573 SLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQN----PLTNRAHTDQRCVRERESLESDH 633
            .::..|::.::.:.||........::::|:.:||||||    |...:...|.:    :......:
Yeast   897 EMSLFPMDPTLSRSLLSSVDNQCSDEIVTIISMLSVQNVFYRPKDRQLEADSK----KAKFHHPY 957

  Fly   634 GDLFTLVRLYNVWVQLKMRRDGTRQWCRRLGIEEQRFYEVTKLRQQFQRILESCGM-VVASDSDS 697
            ||..||:.:|..|.|...    :.|:|:...:..:.......::.|...|.:..|: :::..||.
Yeast   958 GDHLTLLNVYTRWQQANY----SEQYCKTNFLHFRHLKRARDVKSQISMIFKKIGLKLISCHSDP 1018

  Fly   698 QL 699
            .|
Yeast  1019 DL 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	67/174 (39%)
		DEXDc	163..298	CDD:238005	56/137 (41%)
		Helicase_C	358..490	CDD:278689	49/135 (36%)
		HA2	560..640	CDD:214852	21/83 (25%)
		OB_NTP_bind	<792..897	CDD:285018
PRP22	NP_010929.3	Pnp	1..423	CDD:224106	24/152 (16%)
PRP22	NP_010929.3	HrpA	456..1145	CDD:224557	183/594 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810