DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32533 and ECM16

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_013847.1	Gene:	ECM16 / 855158	SGDID:	S000004735	Length:	1267	Species:	Saccharomyces cerevisiae

Alignment Length:	772	Identity:	226/772 - (29%)
Similarity:	369/772 - (47%)	Gaps:	181/772 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 KHLALRLDADELLQEA-----RDQMQSQFRHILLVYLDFRQTEKFQRIRKLRQTQRNLPIARFRK 153
            |.:..:.|.|:.||||     .:..:..|      |::..::::.|:.|      ..||:.....
Yeast   346 KPIIRKEDLDDGLQEAYVPINENSTRKAF------YVEVSRSDEIQKAR------IQLPVFGEEH 398

  Fly   154 DLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS---------IACTQPRRLACVSLCKRVA 209
            .:.||:..:.|||:.|:||.||:|||||:||:.|:.:         :..|||||:|.||:.:|||
Yeast   399 KIMEAIHHNDVVIICGETGSGKTTQVPQFLYEAGFGAEDSPDYPGMVGITQPRRVAAVSMAERVA 463

  Fly   210 HELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDF 274
            :| |.|:|.:|.:||||:.:..:.|.:.|:|:|:|||::.....|.:|.::|:||.||||:..|.
Yeast   464 NE-LGDHGHKVGYQIRFDSTAKEDTKVKFMTDGVLLREMMHDFKLTKYSSIIIDEAHERNINTDI 527

  Fly   275 LLG-VTKCL-LRAR---------PQLKLILMSATINVELFHGYFGEEGARL-------VQVPGRL 321
            |:| :::|: |||:         .:||||:||||:.|..|     .|...|       :||..|.
Yeast   528 LIGMLSRCVRLRAKLHKENPIEHKKLKLIIMSATLRVSDF-----SENKTLFPIAPPVLQVDARQ 587

  Fly   322 FPIKLRY----------------------LPPPA-LELKAGQAT--------------SKRSQRN 349
            ||:.:.:                      |||.| |....||..              .|.|:.|
Yeast   588 FPVSIHFNRRTAFNYTDEAFRKTCKIHQKLPPGAILVFLTGQQEITHMVKRLRKEFPFKKNSKYN 652

  Fly   350 RIDPAPFVQV-----------------LSLIDQ-------QYPTSERGDVLIFVSGVNEIESVVE 390
            :....|..::                 :.:|||       :|...|...    .:|.:|.:...|
Yeast   653 KDLETPVSKMGINSKTTDLEAEDIDFSVQVIDQDKFKSAIRYEEDEGNS----GNGEDEEDEEEE 713

  Fly   391 AVHEYATE-QT---HWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVD 451
            ...|..|| ||   ...||||:|.....:|.:||...|:|.|.|||:||:||||||:.|||:|||
Yeast   714 GFEEVLTEGQTANDPLYVLPLYSLLPTKEQMRVFQKPPQGSRLCIVATNVAETSLTIPGVRYVVD 778

  Fly   452 SGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQY-NAFEAYPTPEIY 515
            ||:.||..::.:...|..:..||||:||:||.|||||||||.|:|||::..: :.||.:..|||.
Yeast   779 SGRSKERKYNESNGVQSFEVGWVSKASANQRSGRAGRTGPGHCYRLYSSAVFEHDFEQFSKPEIL 843

  Fly   516 RVPLDTMLLQMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVE 580
            |:|:::::|||.||.:.::..|||...|:...:.:.|..|:...||..:|.||..|:.::..|:.
Yeast   844 RMPVESIVLQMKSMAIHNIINFPFPTPPDRVALSKAIQLLQYLGALDNKEMITEDGKKMSLFPLS 908

  Fly   581 LSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTN-----------RAHTDQRC---VRERESLES 631
            ....||||:......:..::.:.:.|||.:|..|           :.:.|:..   :||.:  ||
Yeast   909 PRFSKMLLVSDEKACLPYIVAIVSALSVGDPFINEFELGINEISRKPNPDENLDDKIREHD--ES 971

  Fly   632 DHG---------------------------DLFTLVRLYNVWVQLKMRRDGTRQWCRRLGIEEQR 669
            ..|                           |:|.|:.:.:....:.  ::....:.::..:..:.
Yeast   972 TPGMDPELKKELRSKFYKSRSQFSKLDKFSDVFRLLSVVSAMDYVP--KEQKEIFMKKNFLRGKL 1034

  Fly   670 FYEVTKLRQQFQRIL------ESCGMVVAS-DSDSQLTSAERATRHGELRQLKAMKR 719
            ..|:.|||:|...|:      |:..:|:.: |..|.:.|         :.|:|.:|:
Yeast  1035 MEEIVKLRKQLMYIIKSNTSKENIAVVIRNEDLKSDIPS---------VIQIKLLKQ 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	78/198 (39%)
		DEXDc	163..298	CDD:238005	66/154 (43%)
		Helicase_C	358..490	CDD:278689	59/159 (37%)
		HA2	560..640	CDD:214852	24/120 (20%)
		OB_NTP_bind	<792..897	CDD:285018
ECM16	NP_013847.1	HrpA	360..1267	CDD:224557	221/758 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810