Protein Alignment CG32533 and DHX40

DIOPT Version :10

• Sequence 1: NP_728244.1
• Gene: CG32533 / 32933
• FlyBaseID: FBgn0052533
• Length: 1139
• Species: Drosophila melanogaster
• Sequence 2: NP_078888.4
• Gene: DHX40 / 79665
• HGNCID: 18018
• Length: 779
• Species: Homo sapiens
• Alignment Length: 794
• Identity: 217/794 - (27%)
• Similarity: 353/794 - (44%)
• Gaps: 174/794 - (21%)

  Fly   128 RQTEKFQRIRKLRQ----------------------TQRNLPIARFRKDLREALDTSRVVIVAGD 170
            |:.|:.:|.|.|::                      |....||.:.||.:.:|:..:..:||.|:
Human    13 RRQEEGERSRDLQEERLSAVCIADREEKGCTSQEGGTTPTFPIQKQRKKIIQAVRDNSFLIVTGN 77

  Fly   171 TGCGKSTQVPQYLYDFGYRS---IACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTK 232
            ||.||:||:|:|||:.|:..   |..||||::|.:|:.:|||.|:....||:|.:|:||:...:|
Human    78 TGSGKTTQLPKYLYEAGFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSK 142

  Fly   233 LTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLR-----ARPQLKLI 292
            .|.|.::|:|.||:.:....||.::..:||||.|||.|..|.|.|:.|.|.:     .:..||::
Human   143 ETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVV 207

  Fly   293 LMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYLPPPALELKAGQATSKRSQRNRIDP---- 353
            :||||:.:.....:||  ...:..:||||:|::.::.                   |.|.|
Human   208 VMSATMELAKLSAFFG--NCPIFDIPGRLYPVREKFC-------------------NLIGPRDRE 251

  Fly   354 -APFVQVLSLIDQQYPTSE-RGDVLIFVSGVNEIESVVEAV--------HEYATEQT---HWLVL 405
             ..::|.:..:......:| .||:|:|::|..|||...|.:        ::|..:.|   ..|:|
Human   252 NTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLIL 316

  Fly   406 PLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLK 470
            |.:.......|.::|...|.|:|||::||||:.||||:||:|:|||.|.||::|.:.......|:
Human   317 PCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILE 381

  Fly   471 EFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYN-AFEAYPTPEIYRVPLDTMLLQMVSMGLPDV 534
            ...:|||.|.||.||||||..|.|||:|:.:.:| ....:..|||.|..|.:::|.:..:.:.||
Human   382 VVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDV 446

  Fly   535 RAFPFIEAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQL 599
            ..||:::.|....|.:.:..|.|..|:.....:|.||.|:...|:...:...::..:.....:.|
Human   447 IRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLL 511

  Fly   600 LTLAAMLSVQNPLTN------RAHTDQRCVRERESLESDHGDLFTLVRLYNVWVQLKMRRDGT-R 657
            |.:||||||:|....      :...:|| .||..:......|..||..::.     :.:..|. .
Human   512 LPIAAMLSVENVFIRPVDPEYQKEAEQR-HRELAAKAGGFNDFATLAVIFE-----QCKSSGAPA 570

  Fly   658 QWCRR-----------LGIEEQRFYEVTKLRQQ-------FQ----RILESC------------- 687
            .||::           ..:|.|....:.||:||       |:    .:|..|
Human   571 SWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPKETFEGPKHEVLRRCLCAGYFKNVARRS 635

  Fly   688 -----------GMVV----ASDSDSQLTSAERATRHGEL-------------------------- 711
                       |..|    :|....|.|..|....|..|
Human   636 VGRTFCTMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLH 700

  Fly   712 ----RQLKAMKRRQRFEQPRQR----KLLKQSAGRVAEDEEEQEEAQGDDMRDVDFRLRFDPRQL 768
                ..|.::.||:..|..|:|    :.:||....:::|..::.:.:.||....|.|.||
Human   701 EFNAHDLSSVARREVREDARRRWTNKENVKQLKDGISKDVLKKMQRRNDDKSISDARARF----- 760

  Fly   769 ALLER-SSRLDRHS 781
              ||| ..|...||
Human   761 --LERKQQRTQDHS 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_728244.1	HrpA	145..>619	CDD:441249	163/505 (32%)
		OB_NTP_bind	792..897	CDD:400182
DHX40	NP_078888.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		5/14 (36%)
		HrpA	51..>724	CDD:441249	196/699 (28%)
		DEAH box	173..176		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	737..779		13/43 (30%)