DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32533 and ythdc2

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	XP_004910524.1	Gene:	ythdc2 / 779469	XenbaseID:	XB-GENE-5881731	Length:	1457	Species:	Xenopus tropicalis

Alignment Length:	1406	Identity:	317/1406 - (22%)
Similarity:	486/1406 - (34%)	Gaps:	541/1406 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IKKKADEHASS----------RRRTQINLIEFSFLDHK--AEL--------VGLLQAKSRQVGRS 48
            :|||....|||          .::...|||:...|.:|  .||        |..::|::|::|::
Frog   132 LKKKNGSEASSSLMSCTLTQNTKKAVCNLIQRFPLTNKERTELLPKTERGNVYAIEAENREIGKT 196

  Fly    49 LVENEADFWKFVGKYEAMMRSTGQPVLPPRLAEAELSSMQPYHRSKHLALRLDADELLQEARDQM 113
                            :...:.|.|.:|.:..|::
Frog   197 ----------------SGCLNGGIPQVPDKRGESK------------------------------ 215

  Fly   114 QSQFRHILLVYLDFRQTEKFQRIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQ 178
                      |..|||               :||:...::|:...:..::||::.|:||.||:||
Frog   216 ----------YDFFRQ---------------SLPVFEKQEDIIRIIKNNKVVLIVGETGSGKTTQ 255

  Fly   179 VPQYLYDFGYRS-----IACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILF 238
            :||::.|...::     |.||||||||.:|:.:|||.|..:..|..|.:|||.|...:..|.:.|
Frog   256 IPQFILDNCQKNGLPCRIFCTQPRRLAAISVAERVAAERGEIIGQCVGYQIRLESRVSPKTLLTF 320

  Fly   239 ITEGLLLRQLAVA-ANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVEL 302
            .|.|:|||.|... :.|.....:|:||:|||:.|.||||...:..::..|.|||||.||.::|.|
Frog   321 CTNGVLLRTLMGGDSTLSAITHIIVDEVHERDRFSDFLLTKLRDAIQEHPTLKLILSSAALDVNL 385

  Fly   303 FHGYFGEEGARLVQVPGRLFPIK------------------LRYLPPPALELK----------AG 339
            |..|||  |..::.:.||.|.:|                  |:|......|.|          |.
Frog   386 FIRYFG--GCPVIYIQGRPFEVKEMFLEDILRSTGYRNKGMLKYNKEKQCEEKQKTTLTEWYSAK 448

  Fly   340 QATSK-RSQRNRIDPA------------------------------------------------- 354
            |...| .:||.|..||
Frog   449 QKNMKPETQRQRSVPAIKEEYDILDDGGDTAFGQMTEKDANCLEPWLIKEIDACLSDIWLYRDKD 513

  Fly   355 PFVQVLSLID------------------------------------------------------- 364
            .|.|:..||.
Frog   514 AFAQLFHLISTENVSVDYRHSETSATPLMVAAGQGFLSHVEQLISMGANIQSKASNGWMALDWAK 578

  Fly   365 -----------QQYPTS------------------------------------------------ 370
                       :.|..|
Frog   579 HFGQTEVVDLLESYSASLETEDLDENTLVQSDGNDLSIEDRELLKAYHHSFDDEKVDLDLIMHVL 643

  Fly   371 -------ERGDVLIFVSGVNEIESVVEAV----HEYATEQTHWLVLPLHSGQAIADQSKVFDYAP 424
                   :.|.:|||:.|.:||..:.:.:    ..:|.....:.|..|||....:||.||....|
Frog   644 FNICQITDTGAILIFLPGYDEIVGLRDRILLDDKRFADNAQRYHVFMLHSNMQTSDQKKVLKLPP 708

  Fly   425 EGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRT 489
            .|:||.|:||||||||:||:.|.||:|||||||.:|||......||..|:||:||.||||||||.
Frog   709 AGIRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNNVTMLKMVWISKASAIQRKGRAGRC 773

  Fly   490 GPGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQ---MVSMGLPDVRAFPFIEAPETER---I 548
            .||:||||::..::.....:.|||:.|:||..:.|.   :|.:..| |..| .::|||...   :
Frog   774 RPGICFRLFSKLRFQNMLEFQTPELLRIPLHELCLHTKLLVPINCP-VADF-LMKAPEPPPALIV 836

  Fly   549 EQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLT 613
            ...:..||...|:...|.:|.:|..||:||||..:|||:|...:...::.:||:|..|:.::|..
Frog   837 RNAVQMLKTIDAMDNWEDLTEIGHHLADLPVEPHLGKMVLCAVILKCLDPILTIACTLAYRDPFV 901

  Fly   614 NRAHTDQR-----CVRER--ESLESDHGDLFTLVRLYNVWVQLKMRRDG-TRQWCRRLGIEEQRF 670
            ..:...|:     | |:|  ....|||   ..|:|.:..|  .|.:.|| .|.:|.:..:.:...
Frog   902 LPSQASQKRAAMLC-RKRFTAGTFSDH---MALLRAFQAW--QKAKSDGWERAFCEKNFLSQATM 960

  Fly   671 YEVTKLRQQFQRILESCGMVVASDSDSQLTSAERATRHGELRQLKAMKRRQRFEQPRQRKLLKQS 735
            ..:..||.|....|.:.|.|.|..
Frog   961 EIIIGLRTQLLGQLRASGFVRARG----------------------------------------- 984

  Fly   736 AGRVAEDEEEQEEAQGDDMRDVDFRLRFDPRQLALLERSSRLDRHSVVVLLKLLLGSGFYPQLAI 800
                           |.|:|||:.                ..:..:||   |..|.||.||.|..
Frog   985 ---------------GGDIRDVNI----------------NSENWAVV---KAALLSGMYPNLIH 1015

  Fly   801 SDEFNYCKGGGQQFFHTRLKPFVLQHPNSQFAKHFELLKLTESDLLPKPDFYTPKLPLSKRH--- 862
            .|..|....|.::       ..|..||:|               .|.:|.:  .|:|.:...
Frog  1016 VDRENMVLSGVKE-------KRVRFHPSS---------------ALSEPQY--KKIPSANCQAEA 1056

  Fly   863 ------QLLCYQSLLETAKPYLINCIRLPAAQTLLLF---------------SFAI--------- 897
                  ..|.|..:..:.:...|.|..:....|.:||               ||.:
Frog  1057 VQALPTDWLVYDEMTRSHRIANIKCCSVVTPVTAVLFAGPARLPSSALKEPSSFQVGDGIPNDSS 1121

  Fly   898 -----DTNA-GITQIACDGWLGLDLPMPGSGMELLRRAIELRRRWSRLLYDKLDDLKSKQESPSH 956
                 |.|. .:..:..|.||...|....:|:     ..:||::|..|...::       ::||.
Frog  1122 DSEMEDRNTFTLATLKLDEWLHFRLDPEAAGL-----LFQLRQKWQSLFLRRI-------QAPSK 1174

  Fly   957 SSDDRSSALWQDLVDYMALDVAYAIRRL--------LPADI-KRLYT-----HQAPSARL----- 1002
            .        |.. ||...:.|..|:...        .|:.| :|..|     |...|.|:
Frog  1175 P--------WSQ-VDEATIRVIIAVLNTEEQSAGLQQPSGIGQRPRTLNCEDHLLTSGRINNSQK 1230

  Fly  1003 ----AELKENPFAVD--------FPMTPNEEKGGLNVSEHVVYSCLAEQQWTTAMDATLRAEPWQ 1055
                ||..::|.::|        .|....:|||.   |.|                      .|.
Frog  1231 NFTEAESLDDPSSLDRIAPPSAFSPQAKYKEKGN---SLH----------------------KWP 1270

  Fly  1056 CTRCDFELEEFDVLEQLVHRSKCKRRKAQESRTAKTTSTES 1096
            ..:.|....::.:.:...|.|.|:  ....|.:||.:::.|
Frog  1271 EDKSDLSSVKYKLSDNSSHPSPCE--SPSPSSSAKGSNSPS 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	71/195 (36%)
		DEXDc	163..298	CDD:238005	60/140 (43%)
		Helicase_C	358..490	CDD:278689	64/256 (25%)
		HA2	560..640	CDD:214852	26/86 (30%)
		OB_NTP_bind	<792..897	CDD:285018	25/128 (20%)
ythdc2	XP_004910524.1	R3H_DEXH_helicase	76..134	CDD:100077	0/1 (0%)
		HrpA	219..>1046	CDD:224557	240/950 (25%)
		ANK repeat	535..567	CDD:293786	0/31 (0%)
		ANK repeat	569..600	CDD:293786	2/30 (7%)
		OB_NTP_bind	1001..1096	CDD:369483	26/121 (21%)
		YTH	1316..1447	CDD:367840
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920