DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32533 and Tdrd9

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_083332.1	Gene:	Tdrd9 / 74691	MGIID:	1921941	Length:	1383	Species:	Mus musculus

Alignment Length:	899	Identity:	246/899 - (27%)
Similarity:	385/899 - (42%)	Gaps:	190/899 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RSLVENEADFWKFVGKYEAMMRSTGQPVLPPRL-AEAELSSMQPYHRSKHLALRLDADELLQ--- 107
            |.|..::.:.|..:||....:...|   |||.. |||....:|   ||:.:.   :.|...|
Mouse     3 RKLTVDQINDWFTIGKTVTNVELLG---LPPAFPAEAPREEVQ---RSEEVP---NEDPTAQAQV 58

  Fly   108 ---------------EARDQMQSQFRHILLVYLDFRQTE-----------------------KFQ 134
                           .:..|..|:..:|    ..:||.|                       |..
Mouse    59 PVKATAPARPASTSGRSLSQRSSEMEYI----NKYRQLEEQELDIYGQDQPPSGPGLRSPLAKLS 119

  Fly   135 RIRKLRQT---QRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD-FGYRSIAC-- 193
            .:..:.:|   ..:|||.|.::::...::::.|||:.|.||.|||||:|||:.| :..||..|
Mouse   120 NVACIPETTYKYPDLPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQRSAFCNI 184

  Fly   194 --TQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQ 256
              ||||::...|:.:.::.|.....|..|.:|:..|:..|:.|.::::|.|:||:::..|.:|.:
Mouse   185 VVTQPRKIGASSIARWISKERSWTLGGLVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLME 249

  Fly   257 YDALILDEIHERNLFGDFLLGVTKCLLRARPQ-LKLILMSATINVELFHGYFG------EEGARL 314
            :..:.:||:|||....||||.|.:.|||...: :|::|||||||.:.|..||.      ...|.:
Mouse   250 FTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATINCKQFADYFAVPVQNKMNPAYV 314

  Fly   315 VQVPGRLFPIKLRYLPPPALELKAGQATSKRSQRNRIDPAPFVQVLSLIDQ-------------- 365
            .:|.|:...|:..||........:|  ...|.:...|....:...:|||..
Mouse   315 FEVEGKPHAIEEYYLNDLGHIYHSG--LPYRLEEPVITKDVYEVAVSLIQMFDDLDMKESGNKTW 377

  Fly   366 ---QYPTSERGDVLIFVSGVNEIESVVEAVHEYATEQTH--WLVLPLHSGQAIADQSKVFDYAPE 425
               |: .|||..||:|:.|:.||    ..:||..|...|  ..|.||||...:.:|:.||.....
Mouse   378 SGAQF-VSERSSVLVFLPGLGEI----NYMHELLTNMIHKRLQVYPLHSSVTLEEQNNVFLSPVP 437

  Fly   426 GMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTG 490
            |.||.|:||||||:|:||..|::|:|....:.:..|.....|.|:..|.||:|.|||||||||..
Mouse   438 GYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRKGRAGRVS 502

  Fly   491 PGVCFRLYTAEQY-NAFEAYPTPEIYRVPLDTMLL--QMVSMGLPDVRAFPFIEAPETERIEQTI 552
            .|.|:||...:.: :|...:..||:.|.||.:.:|  :::.||.|.......:..|....||:||
Mouse   503 KGYCYRLIPRDFWDSAIPDHVVPEMLRCPLGSTILKVKLLDMGEPRALLATALSPPSLSDIERTI 567

  Fly   553 LALKQHCALSV----------EEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLS 607
            |.||:..||:|          :.::|.|||.||.|||...:||::::|.||..:::.|.:||.||
Mouse   568 LLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVSQQLGKLVVLGHVFGCLDECLIIAAALS 632

  Fly   608 VQNPLTN--RAHTDQRCVRERESLE-SDHGDLFTLVRLYNVWVQLKMRRDGTR-----QWCRRLG 664
            ::|..|.  |.|.|.  .|.:.... |...|...||..:..|...:.|.:..|     .|.|...
Mouse   633 LKNFFTMPFRQHLDG--YRNKVHFSGSSRSDCLALVEAFRAWQACRQRGELRRPKDELDWGRLNY 695

  Fly   665 IEEQRFYEVTKLRQQFQRILESCGMVVASDSDSQLTSAERATRHGELRQLKAMKRR--------- 720
            |:.:|..||.:|.::.:..:....|.|             ...|..|.|....|:|
Mouse   696 IQIKRIREVAELYEELKNRISQFNMFV-------------GPHHPVLDQEYPYKQRFILQVVLAG 747

  Fly   721 ------QRFEQPRQRKLLKQSAGRVAEDEEEQEEAQGDDMRDVDFRLRFDPRQLALLERSSRLDR 779
                  ..|.||.:...:::.||:                         ||:
Mouse   748 AFYPNYFTFGQPDEEMAVRELAGK-------------------------DPK------------- 774

  Fly   780 HSVVVLLKLLLGSGFYPQLAISDEFNYCKGGGQQFFHTRLKPFV--LQHPNSQF 831
              ..|:||.:...||.....:...|..| |..:.......|.||  .::|..:|
Mouse   775 --TTVVLKHIPPYGFLYYKQLQSLFRQC-GQVKSIVFDGAKAFVEFSRNPTERF 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	64/183 (35%)
		DEXDc	163..298	CDD:238005	54/140 (39%)
		Helicase_C	358..490	CDD:278689	57/150 (38%)
		HA2	560..640	CDD:214852	30/92 (33%)
		OB_NTP_bind	<792..897	CDD:285018	10/42 (24%)
Tdrd9	NP_083332.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..82		8/52 (15%)
		HrpA	111..>717	CDD:224557	196/614 (32%)
		DEXDc	151..292	CDD:238005	54/140 (39%)
		DEAH box. /evidence=ECO:0000269\|PubMed:28633017	256..259		2/2 (100%)
		Helicase_C	384..501	CDD:278689	52/120 (43%)
		HA2	589..666	CDD:214852	27/78 (35%)
		TUDOR	905..1014	CDD:278965
		TUDOR	950..997	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820