DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32533 and Dhx30

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_001239612.1	Gene:	Dhx30 / 72831	MGIID:	1920081	Length:	1223	Species:	Mus musculus

Alignment Length:	804	Identity:	233/804 - (28%)
Similarity:	382/804 - (47%)	Gaps:	113/804 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TQINLIEFSFLDHKAELVGL---------LQAKSRQVGRSLVENEA-----DFWKFVGKYE---- 64
            |..||::|..:..|.:|..|         ..||.|:  ::..||:|     ...|.:|..:
Mouse   290 TAKNLMQFHTVGTKTKLATLTLLWPCPMTFVAKGRR--KAEAENKAAALACKKLKSLGLVDRNNE 352

  Fly    65 ---------AMMRSTG------------QPVLPPRLAEAELSS-------MQPYHRSKHLALRLD 101
                     |.:|..|            :|:|  |..||.||.       :.|       .|||.
Mouse   353 PLTHAMYNLASLRELGETQRRPCTIQVPEPIL--RKIEAFLSHYPVDSSWISP-------ELRLQ 408

  Fly   102 ADELLQEARDQMQSQFRHILLVYLDFRQTEKFQRIRKLRQTQR----------NLPIARFRKDLR 156
            :|::|...:|............|:...:.|:.:..:.|.:..|          .||:...|..:.
Mouse   409 SDDILPLGKDSGPLSDPITGKPYMPLSEAEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTIL 473

  Fly   157 EALDTSRVVIVAGDTGCGKSTQVPQYLYD------FGYR-SIACTQPRRLACVSLCKRVAHELLD 214
            .|::...||:::|||||||:|::||.|.:      .|.| ::..|||||::.||:.:||:|||..
Mouse   474 SAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGP 538

  Fly   215 DYGSRVAFQIRFE-RSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGV 278
            .....|.||:|.| :...:...:||.|.|:|||:|....:|:....:|:||:|||::..||||.:
Mouse   539 SLRRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLIL 603

  Fly   279 TKCLLRARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYLPPPALELKAGQATS 343
            .|.|.|..|.|:|:|||||.:.|.|..|||  |..:::|||.::|:|..||.....:|...|...
Mouse   604 LKGLQRLNPALRLVLMSATGDNERFSRYFG--GCPVIKVPGFMYPVKEHYLEDILAKLGKHQYPH 666

  Fly   344 KRSQRNRIDPAPF-----VQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHE-YATEQTHW 402
            :.......|....     ..::..||.:   .|.|.:|.|:.|..||:.|.:.:.| ....::.:
Mouse   667 RHRHHESEDECALDLDLVTDLVLHIDAR---GEPGGILCFLPGWQEIKGVQQRLQEALGMHESKY 728

  Fly   403 LVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQ 467
            |:||:||...:.||..:|...|.|:||.:::|||||||:||:.:..|||||..||..:|...|..
Mouse   729 LILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHVVDSGLHKEERYDLKTKVS 793

  Fly   468 RLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLP 532
            .|:..|||:::..||:|||||...|..:.|:...:......:..|||.|.||:.::|| ..:.:|
Mouse   794 CLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQ-AKIHMP 857

  Fly   533 DVRAFPF----IEAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVF 593
            :..|..|    :::|..:.:::.::.|::...|...|.:|.||:.||::..:..:.|.:::.::|
Mouse   858 EKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIF 922

  Fly   594 PEVEQLLTLAAMLS---VQNPLTNRAHTDQRCVRERESLESDHG-DLFTLVRLYNVWVQLKMRRD 654
            ..:..||.:.:.|:   ..:.|.|||..|    :.:..|..|.| |....||....|.::...:|
Mouse   923 RCLHPLLVVVSCLTRDPFSSSLQNRAEVD----KVKALLSHDSGSDHLAFVRAVAGWEEVLRWQD 983

  Fly   655 GTRQWCRRLGIEEQRFYE-----VTKLRQQF-QRILESCGMVVASDSDSQLTSAERATRHGELRQ 713
            .|   .|...:||...|.     :..|.:|| :.|.|:  .:|...||..|.||:......|...
Mouse   984 RT---SRENYLEENLLYAPSLRFIHGLIKQFSENIYEA--FLVGKPSDCTLPSAQCNEYSEEEEL 1043

  Fly   714 LKAMKRRQRFE---QPRQRKLLKQ 734
            :|.:.....:.   |.||.|:.:|
Mouse  1044 VKGVLMAGLYPNLIQVRQGKVTRQ 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	74/179 (41%)
		DEXDc	163..298	CDD:238005	61/142 (43%)
		Helicase_C	358..490	CDD:278689	52/132 (39%)
		HA2	560..640	CDD:214852	21/83 (25%)
		OB_NTP_bind	<792..897	CDD:285018
Dhx30	NP_001239612.1	DEXDc	467..646	CDD:214692	73/180 (41%)
		DEXDc	481..622	CDD:238005	60/140 (43%)
		HELICc	715..814	CDD:197757	40/98 (41%)
		HA2	886..969	CDD:214852	21/86 (24%)
		OB_NTP_bind	1009..1131	CDD:285018	17/61 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820