DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG32533 and Dhx36

DIOPT Version :9

Sequence 1:NP_001285437.1 Gene:CG32533 / 32933 FlyBaseID:FBgn0052533 Length:1139 Species:Drosophila melanogaster
Sequence 2:NP_082412.2 Gene:Dhx36 / 72162 MGIID:1919412 Length:1001 Species:Mus musculus


Alignment Length:1068 Identity:286/1068 - (26%)
Similarity:458/1068 - (42%) Gaps:233/1068 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KKKADEHASSRRRTQINLIEFSFLDHKAELVGLLQAKSRQVGRSLVENEADFWKFVGK---YEAM 66
            :::|..|...||..||           .:|:..:|||:.:      ::||....|..:   |...
Mouse    73 QERAVVHMDERREEQI-----------VQLLNSVQAKTDK------DSEAQISWFAPEDHGYGTE 120

  Fly    67 MRSTGQPVLPPRLAEAELSSMQPYHRSKHLA----LRLDADELLQEARDQMQSQFRHILLVYLDF 127
            :.|..:.....:|...|...:....::..:.    :..|::.||||....: |..:|:|   .|.
Mouse   121 VSSEKKINSEKKLDNQEKKLLNQEKKTFRITDKSYIDRDSEYLLQENEPNL-SLDQHLL---EDL 181

  Fly   128 RQTEKFQRIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD----FGY 188
            ::.:...|..::::.::.||....:|:|...::..:|.:::|:|||||:|||.|::.|    .|.
Mouse   182 QRKKTDPRYIEMQRFRKKLPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGK 246

  Fly   189 RS---IACTQPRRLACVSLCKRVAHELLDD--YGSRVAFQIRFE-RSRTKLTNILFITEGLLLRQ 247
            .|   |.||||||::.:|:.:|||.|..:.  .|:...:|||.: |...|..:||:.|.|::|:.
Mouse   247 GSACRIVCTQPRRISAISVAERVATERAESCGNGNSTGYQIRLQSRLPRKQGSILYCTTGIILQW 311

  Fly   248 LAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGEEGA 312
            |...:.|.....::|||||||||..|.|:.|.|.||..|..||:||||||:|.|.|..|||  ..
Mouse   312 LQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFG--NC 374

  Fly   313 RLVQVPGRLFPI----------KLRYLPPP---ALELKAG--QATSKRSQRNRID---------- 352
            .::.:||..||:          |:||:|..   ..:.|.|  |....|.::...:          
Mouse   375 PMIHIPGFTFPVVEYLLEDIIEKIRYVPDQKEHRSQFKRGFMQGHVNRQEKEEKEAIYKERWPAY 439

  Fly   353 --------PAPFVQVLSLIDQ------------QYPT--SERGDVLIFVSGVNEIESVVEAVHEY 395
                    .|..|.||.::|.            :|..  .|.|.:|:|:.|.:.|.:    :|:.
Mouse   440 IKELRTRYSASTVDVLQMMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNIST----LHDL 500

  Fly   396 ATEQT-----HWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKV 455
            ...|.     .:|::||||.....:|::||...|.|:||.:::|||||||:|:|.|.:|:|.||:
Mouse   501 LMSQVMFKSDKFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGKI 565

  Fly   456 KEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLD 520
            ||.:||.......:...||||::|.||||||||..||.|:.||...:.:..:.|..|||.|.||:
Mouse   566 KETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLE 630

  Fly   521 TMLLQMVSMGLPDVRAF--PFIEAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSI 583
            .:.||:..:.|..:..|  ..::.|..|.:..:|..|.:..||..:|::||||..||.||||..|
Mouse   631 ELCLQIKILRLGGIAYFLSRLMDPPSNEAVVLSIKHLMELSALDKQEELTPLGVHLARLPVEPHI 695

  Fly   584 GKMLLMGSVFPEVEQLLTLAAMLSVQN----PLTNRAHTDQRCVRERESLESDHGDLFTLVRLYN 644
            |||:|.|::|..::.:||:||.||.::    ||......|.|.....:...|||   .|:|..:.
Mouse   696 GKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKELAKETRSDH---LTVVNAFE 757

  Fly   645 VWVQLKMRRDGTR---QWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVASDSDSQLTSAERAT 706
            .|.:.|.|  |.|   .:|....:.......:..::.||...|...|.|.:              
Mouse   758 GWEEAKRR--GFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSS-------------- 806

  Fly   707 RHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEEQEEAQGDDMRDVDFRLRFDPRQLALL 771
                             ..|:..|      ..:..|.|:                          
Mouse   807 -----------------RSPKDPK------ANINSDNEK-------------------------- 822

  Fly   772 ERSSRLDRHSVVVLLKLLLGSGFYPQLAISDEFNYCKGGGQQFFHTRLKPFVLQHPNSQFAKHFE 836
                         ::|.::.:|.||::| ....|..|.......||:....|..||.|       
Mouse   823 -------------IIKAVICAGLYPKVA-KIRLNLGKKRKMVKVHTKSDGLVSIHPKS------- 866

  Fly   837 LLKLTESDLLPKPDFYTPKLPLSKRHQLLCYQSLLETAKPYLINCIRLPAAQTLLLFSFAIDTNA 901
             :.:.::|.               .:..|.|...:.|:..||.:|..: :...||.|...|....
Mouse   867 -VNVEQTDF---------------HYNWLIYHLKMRTSSIYLYDCTEV-SPYCLLFFGGDISIQK 914

  Fly   902 GITQ--IACDGWLGLDLPMPGSGMELLRRAIE-LRRRWSRLLYDKLDDLKSKQESPSHSSD---- 959
            ...|  ||.|.|:....|      |.:...:: ||:....||.:|:       ||| |..|    
Mouse   915 DKDQEIIAVDEWIVFQSP------ERIAHLVKGLRKELDSLLQEKI-------ESP-HPVDWDDT 965

  Fly   960 -DRSSALWQDLVDYMALDVAYAIRRLLP 986
             .|..|:...::|.:........|.|.|
Mouse   966 KSRDCAVLSAILDLIKTQEKATPRNLPP 993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32533NP_001285437.1 DEXDc 155..327 CDD:214692 75/191 (39%)
DEXDc 163..298 CDD:238005 62/144 (43%)
Helicase_C 358..490 CDD:278689 55/150 (37%)
HA2 560..640 CDD:214852 34/83 (41%)
OB_NTP_bind <792..897 CDD:285018 22/104 (21%)
Dhx36NP_082412.2 Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250|UniProtKB:Q9H2U1 1..193 27/140 (19%)
Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8 1..97 7/34 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250|UniProtKB:Q9H2U1 1..44
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H2U1 46..98 8/35 (23%)
DSM (DHX36-specific motif). /evidence=ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q9H2U1 46..68
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 99..379 90/291 (31%)
HrpA 188..894 CDD:224557 232/816 (28%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 258..310 17/51 (33%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 327..330 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 380..621 75/244 (31%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 491..550 20/62 (32%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9H2U1 510..521 5/10 (50%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 622..691 24/68 (35%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 631..690 17/58 (29%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 834..898 17/87 (20%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 842..853 2/10 (20%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 863..893 8/52 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D222681at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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