DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32533 and Dhx34

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_001258381.1	Gene:	Dhx34 / 684903	RGDID:	1584452	Length:	1143	Species:	Rattus norvegicus

Alignment Length:	1116	Identity:	483/1116 - (43%)
Similarity:	658/1116 - (58%)	Gaps:	73/1116 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 FWKF---VGKYEAMMRS-----TGQPV--------LP----PRLAEAELSSMQPYHRSKHLALRL 100
            ||.|   :.||:.:..|     .|||.        ||    ||. ...||.:.|..|.:|
  Rat    62 FWAFFERLQKYQHLKTSQKEKDPGQPKHGIAALADLPCTYDPRY-RINLSILGPDTRGRH----- 120

  Fly   101 DADELLQEARDQMQSQFRHILLVYLDFRQTEKFQRIRKLRQTQRNLPIARFRKDLREALDTSRVV 165
            ...:.|...|   .|:||..||.||||:|.:.|.|:.||::.:..||||::...:.:.|...:||
  Rat   121 GPGKGLPPER---VSEFRRALLHYLDFQQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQVV 182

  Fly   166 IVAGDTGCGKSTQVPQYLYDFGYRSIACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSR 230
            :|||||||||||||||||...|:..:|||||||:||:||.|||..|.|..|||:|.:|||||.:|
  Rat   183 VVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTR 247

  Fly   231 TKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMS 295
            :..|.|:|:|.||||||:.....|.||..||:||:|||:|..||||||.:.||..||.||:||||
  Rat   248 SAATKIVFLTVGLLLRQIQCEPRLPQYQVLIVDEVHERHLHNDFLLGVLQRLLPQRPDLKVILMS 312

  Fly   296 ATINVELFHGYFGEEGARLVQVPGRLFPIKLRYLPPPALELKAGQATSKRSQRNRIDPAPFVQVL 360
            ||||:.||..||..  |.:||||||||||.:.|.|.        :|....|:..::||.||::||
  Rat   313 ATINISLFSSYFSH--APVVQVPGRLFPITVVYQPQ--------EAEQSASKSEKLDPRPFLRVL 367

  Fly   361 SLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHEYATEQTHWLVLPLHSGQAIADQSKVFDYAPE 425
            ..||.:||..||||:|:|:||:.||.:|::|...|||....|:||||||..::|||.||||.||.
  Rat   368 EAIDNKYPPEERGDLLVFLSGMAEISTVLDAAQAYATLTQRWVVLPLHSALSVADQDKVFDVAPA 432

  Fly   426 GMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTG 490
            |:||||:||||||||:|:||:||||||||||||::|...|.|||:|||:|::||:||||||||||
  Rat   433 GVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTG 497

  Fly   491 PGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETERIEQTILAL 555
            ||||:|||....|:||..||.|||.||.||.::|||.||.:.|.|.|||||.|....:|..||.|
  Rat   498 PGVCYRLYAESDYDAFAPYPVPEIRRVALDALVLQMKSMSVGDPRTFPFIEPPPAASVETAILYL 562

  Fly   556 KQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTDQ 620
            :...||...|.:||:|..||.|||::.||||:::||:|...|.:||:||.||||:|.|..|.::.
  Rat   563 QDQGALDSSEALTPIGSLLAQLPVDVVIGKMMILGSMFSLAEPVLTIAAALSVQSPFTRSAQSNL 627

  Fly   621 RCVRERESLESDHGDLFTLVRLYNVWVQLKMRRDG-TRQWCRRLGIEEQRFYEVTKLRQQFQRIL 684
            .|...|..||||.||.|||..::|.|||:|..|.| :|:||||.|:||.|.||:..||:||:.:|
  Rat   628 DCATARRPLESDQGDPFTLFNVFNAWVQVKSERSGNSRKWCRRRGVEEHRLYEMANLRRQFKELL 692

  Fly   685 ESCGMVVASDSDSQLTSAERATRHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEEQ--- 746
            |..|::..:...:...|..|..:..|.:.|..:||:......|:||:|:......:.||:.:
  Rat   693 EDHGLLRGAQVVAPRDSYSRLQQRRERQTLHQLKRQHEEGGGRRRKVLRLQEDGCSSDEDHEGSA 757

  Fly   747 -EEAQGDDMRDVDFRLRFDPRQLALLERSSRLDRHSVVVLLKLLLGSGFYPQLAISDEFNYCKGG 810
             :.|...|::||.|:||.:..||.....|::......:.||||:||.|.|||||:.|.||..:..
  Rat   758 SQRADSVDIQDVKFKLRHNLEQLQAAASSAQDLTRDQLALLKLVLGRGLYPQLAVPDAFNSGRKD 822

  Fly   811 GQQFFHTRLKPFVLQHPNSQFAKHFELLKLTESDLLPKPDFYTPKLPLSKRHQLLCYQSLLETAK 875
            ..|.|||:.|...:.||...||...|:|.....:...:......|..:|.:||||.:.|||||.|
  Rat   823 SDQIFHTQAKQGTVLHPTCVFANSPEVLHTQGPEASGREGSQDGKDQMSCKHQLLAFVSLLETNK 887

  Fly   876 PYLINCIRLPAAQTLLLFSFAIDTNAGITQIACDGWLGLDLPMPGSGMELLRRAIELRRRW---- 936
            |||:||:|:||.|:|||||.:||||...:::..||||.|.|....|.:.||..::.||..|
  Rat   888 PYLVNCVRIPALQSLLLFSRSIDTNGDCSRLVADGWLELQLADSESAVRLLATSLRLRAHWESAL 952

  Fly   937 SRLLYDKLDDLKSKQESPSHS---SDDRSSALWQDLVDYMALDVAYAIRRLLPADIKRLYT---- 994
            .|.|..:....|.:||....|   |....:||.::|:.:||..|.|.:|||...:.:.||.
  Rat   953 DRQLAQQAQRRKLEQEEDPESPAVSPQEVAALSRELLQFMAAKVPYRLRRLTGLEAQNLYVGPQT 1017

  Fly   995 -HQAPSARLAELKENPFAVDFPMTPNEEKGGLNVSEHVVYSCLAEQQWTTAMDATLRAEPWQCTR 1058
             ..|||  |..|..|..     ::|:..|||..||:::.|:||...  |......||:. |.|..
  Rat  1018 ITTAPS--LPGLFGNSI-----LSPHPTKGGYAVSDYLTYNCLTSD--TDLYSDCLRSF-WTCPH 1072

  Fly  1059 CDFELEEFDVLEQLVHRSKCKRRKAQESRTAKTTSTESSTEVASSSSSHSSGGYYCNSCKRELRL 1123
            |...: .|..||::.|.:.|....:.      ...:|.:..|.:..:|.....|:|..|.::...
  Rat  1073 CGLHM-PFTPLERIAHENTCPEAPSD------GPGSEEAAPVPTQKTSALQRPYHCQVCGQDFLF 1130

  Fly  1124 TTIDILRHKKQ 1134
            |..::|||::|
  Rat  1131 TPTEVLRHRRQ 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	103/171 (60%)
		DEXDc	163..298	CDD:238005	84/134 (63%)
		Helicase_C	358..490	CDD:278689	84/131 (64%)
		HA2	560..640	CDD:214852	40/79 (51%)
		OB_NTP_bind	<792..897	CDD:285018	46/104 (44%)
Dhx34	NP_001258381.1	HrpA	155..>687	CDD:224557	300/541 (55%)
Dhx34	NP_001258381.1	OB_NTP_bind	798..909	CDD:400182	51/110 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334371
Domainoid	1	1.000	260	1.000	Domainoid score	I1907
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69171
Inparanoid	1	1.050	817	1.000	Inparanoid score	I448
OMA	1	1.010	-	-		QHG49470
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0006245
OrthoInspector	1	1.000	-	-		oto98735
orthoMCL	1	0.900	-	-		OOG6_107230
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4527
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810