DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32533 and Dhx40

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_080467.3	Gene:	Dhx40 / 67487	MGIID:	1914737	Length:	779	Species:	Mus musculus

Alignment Length:	753	Identity:	211/753 - (28%)
Similarity:	344/753 - (45%)	Gaps:	142/753 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 TQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS---IACTQPRRLACVS 203
            |....||.:.||.|.:|:..:..:||.|:||.||:||:|:|||:.|:..   |..||||::|.:|
Mouse    49 TTPTFPIQKQRKKLIQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIGVTQPRKVAAIS 113

  Fly   204 LCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHER 268
            :.:|||.|:....||:|.:|:||:...:|.|.|.::|:|.||:.:....||.::..:||||.|||
Mouse   114 VAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLSKFSVIILDEAHER 178

  Fly   269 NLFGDFLLGVTKCLLR-----ARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRY 328
            .|..|.|.|:.|.|.:     .:..||:::||||:.:.....:||  ...:..:||||:|::.::
Mouse   179 TLTTDILFGLLKKLFQDKSPNRKEHLKVVVMSATMELAKLSAFFG--NCPIFDIPGRLYPVREKF 241

  Fly   329 LPPPALELKAGQATSKRSQRNRIDPAPFVQVLSLIDQQYPTSE-RGDVLIFVSGVNEIESVVEAV 392
            .          .....|.:.|    ..::|.:..:......:| .||:|:|::|..|||...|.:
Mouse   242 C----------NLIGPRDREN----TAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELL 292

  Fly   393 --------HEYATEQT---HWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGV 446
                    ::|..:.|   ..|:||.:.......|.::|...|.|:|||::||||:.||||:||:
Mouse   293 FQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGI 357

  Fly   447 RFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYN-AFEAYP 510
            |:|||.|.||::|.:.......|:...:|||.|.||.||||||..|.|||:|:.|.:: ....:.
Mouse   358 RYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTASGKCFRIYSKEFWSQCMPDHV 422

  Fly   511 TPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCALSVEEKITPLGRSLA 575
            .|||.|..|.:::|.:..:.:.||..||:::.|....|.:.:..|.|..|:.....:|.||.|:.
Mouse   423 IPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMV 487

  Fly   576 NLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTN------RAHTDQRCVRERESLESDHG 634
            ..|:...:...::..:.....:.||.:||||||:|....      :...:|| .||..:......
Mouse   488 EFPLPPHLTCAVIRAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQR-HRELAAKAGGFN 551

  Fly   635 DLFTLVRLYNVWVQLKMRRDGT-RQWCRR-----------LGIEEQRFYEVTKLRQQ--FQR--- 682
            |..||..::.     :.:..|. ..||::           ..:|.|....:.||:||  |.|
Mouse   552 DFATLAVIFE-----QCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPRETF 611

  Fly   683 ------ILESC------------------------GMVV----ASDSDSQLTSAERATRHGEL-- 711
                  :|..|                        |..|    :|....|.|..|....|..|
Mouse   612 EGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVT 676

  Fly   712 ----------------------------RQLKAMKRRQRFEQPRQ----RKLLKQSAGRVAEDEE 744
                                        ..|.::.||:..|..|:    ::.:||....::::..
Mouse   677 TKVYARIVCPIRYEWVRDLLPKLHELNAHDLSSVARREMREDARRKWTNKENVKQLKDGISKEVL 741

  Fly   745 EQEEAQGDDMRDVDFRLRFDPRQLALLER-SSRLDRHS 781
            ::.:.:.||....|.|.||       ||| ..|:..||
Mouse   742 KKMQRRNDDKSISDARARF-------LERKQQRIQDHS 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	68/179 (38%)
		DEXDc	163..298	CDD:238005	58/142 (41%)
		Helicase_C	358..490	CDD:278689	53/143 (37%)
		HA2	560..640	CDD:214852	21/85 (25%)
		OB_NTP_bind	<792..897	CDD:285018
Dhx40	NP_080467.3	OB_NTP_bind	591..699	CDD:285018	17/107 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		1/3 (33%)
		DEXDc	48..236	CDD:214692	72/188 (38%)
		DEXDc	78..213	CDD:238005	55/134 (41%)
		DEAH box	173..176		2/2 (100%)
		HELICc	312..399	CDD:197757	38/86 (44%)
		HA2	469..557	CDD:214852	22/88 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810