DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32533 and YTHDC2

DIOPT Version :9

Sequence 1:NP_001285437.1 Gene:CG32533 / 32933 FlyBaseID:FBgn0052533 Length:1139 Species:Drosophila melanogaster
Sequence 2:XP_011541883.1 Gene:YTHDC2 / 64848 HGNCID:24721 Length:1439 Species:Homo sapiens


Alignment Length:1388 Identity:322/1388 - (23%)
Similarity:495/1388 - (35%) Gaps:488/1388 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 EFSFLDHKAELVGLLQAKSRQVGRSLVENEADFWKFVGKYEAMMRSTGQPVLPPRLAEAELSSMQ 88
            |.:|:...::.:||: :||:..|             ..:|..:.:..|.     ..|.| :.:..
Human    74 ERAFIHRLSQSLGLV-SKSKGKG-------------ANRYLTVKKKDGS-----ETAHA-MMTCN 118

  Fly    89 PYHRSKHLALRL---------DADELLQEARDQMQSQFRHILLVYLDFRQTEK------------ 132
            ..|.:||....|         :..|||.      :::..::..|..:.|:..|            
Human   119 LTHNTKHAVRSLIQRFPVTNKERTELLP------KTERGNVFAVEAENREMSKTSGRLNNGIPQI 177

  Fly   133 --------FQRIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYR 189
                    |...|      ::||:...::::.:.:..::||::.|:||.||:||:||:|.|..::
Human   178 PVKRGESEFDSFR------QSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFK 236

  Fly   190 S-----IACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQL- 248
            :     |.||||||||.:::.:|||.|..:..|..:.:|||.|...:..|.:.|.|.|:|||.| 
Human   237 NGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLM 301

  Fly   249 AVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGEEGAR 313
            |..:.|.....:|:||:|||:.|.||||...:.||:..|.|||||.||.::|.||..|||  ...
Human   302 AGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFG--SCP 364

  Fly   314 LVQVPGRLFPIK------------------LRYLPPPALELK---------AGQATS--KRSQRN 349
            ::.:.||.|.:|                  |:|......|.|         :.|..|  ..|||.
Human   365 VIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEEKQQTTLTEWYSAQENSFKPESQRQ 429

  Fly   350 RI-------------------------------------------------DPAPFVQVLSLI-- 363
            |.                                                 |...|.||..||  
Human   430 RTVLNVTDEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDIDAFAQVFHLILT 494

  Fly   364 ---DQQYPTSE------------------------------------------------------ 371
               ...|..||                                                      
Human   495 ENVSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLL 559

  Fly   372 --------------------------------------------------------------RGD 374
                                                                          .|.
Human   560 ESYSATLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGA 624

  Fly   375 VLIFVSGVNEIESVVEAV----HEYATEQTHWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTN 435
            ||||:.|.:||..:.:.:    ..:|.....:.|..|||....:||.||....|.|:||.|:|||
Human   625 VLIFLPGYDEIVGLRDRILFDDKRFADSTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTN 689

  Fly   436 IAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTA 500
            |||||:||:.|.||:|||||||.:|||......||..|:||:||.||||||||..||:||||::.
Human   690 IAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSR 754

  Fly   501 EQYNAFEAYPTPEIYRVPLD-----TMLLQMVSMGLPDVRAFPFIEAPETER---IEQTILALKQ 557
            .::.....:.|||:.|:||.     |.||..|:..:.|.    .::|||...   :...:..||.
Human   755 LRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCPIADF----LMKAPEPPPALIVRNAVQMLKT 815

  Fly   558 HCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTDQR- 621
            ..|:...|.:|.||..||:||||..:|||:|...|...::.:||:|..|:.::|........|: 
Human   816 IDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKR 880

  Fly   622 ----CVRER--ESLESDHGDLFTLVRLYNVWVQLKMRRDGTRQWCRRLGIEEQRFYEVTKLRQQF 680
                | |:|  ....|||   ..|:|.:..|  .|.|.||   |       |:.|.|...|.|..
Human   881 AAMLC-RKRFTAGAFSDH---MALLRAFQAW--QKARSDG---W-------ERAFCEKNFLSQAT 929

  Fly   681 QRILESCGMVVASDSDSQLTSAERATRHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEE 745
            ..|:  .||              |....|:||....::.|                         
Human   930 MEII--IGM--------------RTQLLGQLRASGFVRAR------------------------- 953

  Fly   746 QEEAQGDDMRDVDFRLRFDPRQLALLERSSRLDRHSVVVLLKLLLGSGFYPQLAISDEFNYCKGG 810
                .|.|:|||                ::..:..:||   |..|.:|.||.|...|..|....|
Human   954 ----GGGDIRDV----------------NTNSENWAVV---KAALVAGMYPNLVHVDRENLVLTG 995

  Fly   811 GQQFFHTRLKPFVLQHPNSQFAKHFELLKLTESDLLPKPDFYTPKLPLSKRH---------QLLC 866
            .::       ..|..||.|               :|.:|.:  .|:|.:...         ..|.
Human   996 PKE-------KKVRFHPAS---------------VLSQPQY--KKIPPANGQAAAIKALPTDWLI 1036

  Fly   867 YQSLLETAKPYLINCIRLPAAQTLLLF---------------SFAID--------------TNAG 902
            |..:....:...|.|.......|:|:|               ||.:|              |.|.
Human  1037 YDEMTRAHRIANIRCCSAVTPVTILVFCGPARLASNALQEPSSFRVDGIPNDSSDSEMEDKTTAN 1101

  Fly   903 ITQIACDGWLGLDLPMPGSGMELLRRAIELRRRWSRLL----------YDKLDDLKSKQESPSHS 957
            :..:..|.||...|....:.:     .::||::|..|.          :.::|:...:......|
Human  1102 LAALKLDEWLHFTLEPEAASL-----LLQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLS 1161

  Fly   958 SDDRSSALWQDLVDYMALDVAYAIRRLLPADIKRLYTHQAPSARLAELKENPFAVDFPMTPNEEK 1022
            ::::|:.|.|                  |:.|     .|.|....:|  |.|.|..: .:.|..|
Human  1162 TEEQSAGLQQ------------------PSGI-----GQRPRPMSSE--ELPLASSW-RSNNSRK 1200

  Fly  1023 GGLNVSEHVVYSCLAEQQWTTAMDATLRAEPWQCTRCDFELEEFDVLEQLVHRSKCKRRKAQESR 1087
            ...:..        ...:.||| :..|...|........:.::..:|    |..:....::.:| 
Human  1201 SSADTE--------FSDECTTA-ERVLMKSPSPALHPPQKYKDRGIL----HPKRGTEDRSDQS- 1251

  Fly  1088 TAKTTSTESSTEVASSSSSHSSG 1110
            :.|:|.:.|.....:|.|..|||
Human  1252 SLKSTDSSSYPSPCASPSPPSSG 1274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32533NP_001285437.1 DEXDc 155..327 CDD:214692 72/195 (37%)
DEXDc 163..298 CDD:238005 62/140 (44%)
Helicase_C 358..490 CDD:278689 67/256 (26%)
HA2 560..640 CDD:214852 28/86 (33%)
OB_NTP_bind <792..897 CDD:285018 24/128 (19%)
YTHDC2XP_011541883.1 R3H_DEXH_helicase 46..104 CDD:100077 8/43 (19%)
HrpA 189..>1016 CDD:224557 247/942 (26%)
DEXHc_YTHDC2 193..368 CDD:350745 70/176 (40%)
ANK repeat 505..537 CDD:293786 1/31 (3%)
ANK repeat 539..564 CDD:293786 0/24 (0%)
OB_NTP_bind 971..1066 CDD:369483 25/121 (21%)
YTH 1288..1404 CDD:367840
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D222681at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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