DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32533 and Dhx38

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_848467.1	Gene:	Dhx38 / 64340	MGIID:	1927617	Length:	1228	Species:	Mus musculus

Alignment Length:	675	Identity:	218/675 - (32%)
Similarity:	351/675 - (52%)	Gaps:	97/675 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 QPVLPPRLAEAELSSMQPYHRSKHLALRLDADELLQEARDQMQSQFRHILLV------------- 123
            :||:|.:.|.::|:.:.   |.....:|..     :|.:::.::|.:|..|.
Mouse   429 EPVIPVKDATSDLAIIA---RKGSQTVRKH-----REQKERRKAQHKHWELAGTKLGDIMGVKKE 485

  Fly   124 -----------YLDFRQTEK--------------FQRIRKLRQTQRNLPIARFRKDLREALDTSR 163
                       .:|:|..:|              |.:.:.:.:.::.|||...:::|...:..:.
Mouse   486 EEPDKAMTEDGKVDYRTEQKFADHMKEKSEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNS 550

  Fly   164 VVIVAGDTGCGKSTQVPQYLYDFGYRS---IACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIR 225
            :|||.|:||.||:||:.|||::.||..   |.||||||:|.:|:.|||:.|:..:.|..|.:.||
Mouse   551 IVIVVGETGSGKTTQLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIR 615

  Fly   226 FERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLK 290
            ||...::.|.|.::|:|:|||:....|:||.|.|:|:||.|||:|..|.|.|:.:.::..|..||
Mouse   616 FEDCTSENTLIKYMTDGILLRESLREADLDHYSAVIMDEAHERSLNTDVLFGLLREVVARRSDLK 680

  Fly   291 LILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYLPPPALELKAGQATSKRSQRNRIDPAP 355
            ||:.|||::.|.|..:||  ...:..:|||.||:.:.:...|..:..  :|..|:|.:..:..||
Mouse   681 LIVTSATMDAEKFAAFFG--NVPIFHIPGRTFPVDILFSKTPQEDYV--EAAVKQSLQVHLSGAP 741

  Fly   356 FVQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHEYATEQTH---WLVLPLHSGQAIAD-Q 416
                             ||:|||:.|..:||...:.:.|:..|..:   ..|||::| |..:| |
Mouse   742 -----------------GDILIFMPGQEDIEVTSDQIVEHLEELENAPALAVLPIYS-QLPSDLQ 788

  Fly   417 SKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQ 481
            :|:|..||:|:|||||:||||||||||||:.||:|||..|...|:.......|:.:.:|:::|:|
Mouse   789 AKIFQKAPDGVRKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQ 853

  Fly   482 RKGRAGRTGPGVCFRLYTAEQY-NAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPET 545
            |.|||||||||.||||||...| |.......|||.|..|..::|.:.|:|:.|:..|.|::.|..
Mouse   854 RSGRAGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQFHFMDPPPE 918

  Fly   546 ERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSV-- 608
            :.:..::..|....||.....:|..||.:...|::.::.|||::........::|.:.:||||
Mouse   919 DNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIVSMLSVPA 983

  Fly   609 --QNPLTNRAHTDQRCVRERESL-ESDHGDLFTLVRLYNVWVQLKMRRDGTRQWCRRLGIEEQRF 670
              ..|......:||  :||:.:: ||||      :...||::|.|.....| .||....|..:..
Mouse   984 IFYRPKGREEESDQ--IREKFAVPESDH------LTYLNVYLQWKNNNYST-IWCNDHFIHAKAM 1039

  Fly   671 YEVTKLRQQFQRI-------LESCG 688
            .:|.::|.|.:.|       |.|||
Mouse  1040 RKVREVRAQLKDIMVQQRMSLASCG 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	74/174 (43%)
		DEXDc	163..298	CDD:238005	63/137 (46%)
		Helicase_C	358..490	CDD:278689	56/135 (41%)
		HA2	560..640	CDD:214852	23/84 (27%)
		OB_NTP_bind	<792..897	CDD:285018
Dhx38	NP_848467.1	DEXDc	527..714	CDD:214692	77/188 (41%)
		DEXDc	552..688	CDD:238005	63/135 (47%)
		HELICc	759..862	CDD:197757	48/103 (47%)
		HA2	931..1013	CDD:214852	23/89 (26%)
		OB_NTP_bind	<1064..1147	CDD:285018	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810