Protein Alignment CG32533 and DHX37

DIOPT Version :10

• Sequence 1: NP_728244.1
• Gene: CG32533 / 32933
• FlyBaseID: FBgn0052533
• Length: 1139
• Species: Drosophila melanogaster
• Sequence 2: XP_005253647.1
• Gene: DHX37 / 57647
• HGNCID: 17210
• Length: 1175
• Species: Homo sapiens
• Alignment Length: 894
• Identity: 229/894 - (25%)
• Similarity: 366/894 - (40%)
• Gaps: 291/894 - (32%)

  Fly   135 RIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS----IACTQ 195
            |..::::.:..|||....:.:.||:....:|||.|:||.||:|||||:||:.|:.|    |..|:
Human   241 RSPEMQEERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVTE 305

  Fly   196 PRRLACVSLCKRVAHELLDDYGSR-VAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDA 259
            |||:|.|::.:|||.|:  :...| |::|||:|.:.|:.|.|.|:|:|:||:::.....|.:|..
Human   306 PRRVAAVAMSQRVAKEM--NLSQRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKV 368

  Fly   260 LILDEIHERNLFGDFLLGVTKCLLRARPQ----LKLILMSATINVELFHGYFGEEGARL------ 314
            :|:||.|||:::.|.|:|:...::..|.:    |||::||||:.||.|     .:..||
Human   369 VIIDEAHERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMSATLRVEDF-----TQNPRLFAKPPP 428

  Fly   315 -VQVPGRLFPIKLRYLPPPALELKAGQATSKRSQRNRIDPAPFVQVLSLIDQQYPTSERGDVLIF 378
             ::|..|.||:.:.:.....||..:|:...|..:.:|:.||                  |.:|:|
Human   429 VIKVESRQFPVTVHFNKRTPLEDYSGECFRKVCKIHRMLPA------------------GGILVF 475

  Fly   379 VSGVNEIESV-------------------------VEAVHEYATEQT----------------HW 402
            ::|..|:.::                         ||.:.::...:.                |:
Human   476 LTGQAEVHALCRRLRKAFPPSRARPQEKDDDQKDSVEEMRKFKKSRARAKKARAEVLPQINLDHY 540

  Fly   403 L------------------------------------------------VLPLHSGQAIADQSKV 419
            .                                                ||||:|..|...|::|
Human   541 SVLPAGEGDEDREAEVDEEEGALDSDLDLDLGDGGQDGGEQPDASLPLHVLPLYSLLAPEKQAQV 605

  Fly   420 FDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKG 484
            |...|||.|.|:|:||:||||||:.|:::|||.||||:..:|........:..|||::|||||.|
Human   606 FKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAG 670

  Fly   485 RAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETERI- 548
            |||||.||.|:|||::..:..||.:|.|||.|.|::.::|||.::.:..|..|||...|..|.:
Human   671 RAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVEKVINFPFPTPPSVEALL 735

  Fly   549 --EQTILAL-------KQHCALSVEEK-----ITPLGRSLANLPVELSIGKMLLMGSVFPEVEQL 599
              |:.::||       |......::|.     ||.|||::|..||.....|||.:......:...
Human   736 AAEELLIALGALQPPQKAERVKQLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYA 800

  Fly   600 LTLAAMLSVQ---NPLTNRAHTDQRCVRERESLESDH-------------------GDLFTLVRL 642
            :|:.|.::|:   ..|...|.:|:...|    |:|..                   |||..|:..
Human   801 ITIVASMTVRELFEELDRPAASDEELTR----LKSKRARVAQMKRTWAGQGASLKLGDLMVLLGA 861

  Fly   643 YNVWVQLKMRRDGTRQWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVASDSDSQLTSAERATR 707
            .........    |.|:|...|:..:...|:.:||                   .|||:|..|
Human   862 VGACEYASC----TPQFCEANGLRYKAMMEIRRLR-------------------GQLTTAVNA-- 901

  Fly   708 HGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEEQEEAQGDDMRDVDFRLRFDPRQLALLE 772
                                           |..:.|                |..||:.....|
Human   902 -------------------------------VCPEAE----------------LFVDPKMQPPTE 919

  Fly   773 RSSRLDRHSVVVLLKLLLGSGFYPQLA--ISDEFNYCKGGGQQFFHTRLKPFVLQHPNSQFAKHF 835
                    |.|..|:.::.:|....||  :..|
Human   920 --------SQVTYLRQIVTAGLGDHLARRVQSE-------------------------------- 944

  Fly   836 ELLK-----LTESDLLPKPDFYTPKLPLSKR-HQLLCYQSLLETAKPYL 878
            |:|:     ..::.||..|.|..|...|.|. .:.:.||.::||.|.|:
Human   945 EMLEDKWRNAYKTPLLDDPVFIHPSSVLFKELPEFVVYQEIVETTKMYM 993

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_728244.1	HrpA	145..>619	CDD:441249	180/596 (30%)
		OB_NTP_bind	792..897	CDD:400182	19/95 (20%)
DHX37	XP_005253647.1	HrpA	252..>1043	CDD:441249	228/883 (26%)