DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32533 and dhx30

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	XP_021322211.1	Gene:	dhx30 / 570735	ZFINID:	ZDB-GENE-130530-833	Length:	1173	Species:	Danio rerio

Alignment Length:	1032	Identity:	269/1032 - (26%)
Similarity:	458/1032 - (44%)	Gaps:	205/1032 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ASSRRRTQINLIEFSFLDHKAELVGLLQAKSRQVGRSLVENEADFWKFVGKYEAMMRSTG----Q 72
            ||.|||          |:.:|....|...|.:::  :|::.:.........::..:|..|    |
Zfish   249 ASGRRR----------LEAEANAAALACLKLKEL--NLLDEQNKPLTHARYHQDQVREAGERHRQ 301

  Fly    73 PV---LPPRL------------AEAELSSM--QPYHRSKHLALR---LDADELLQEA------RD 111
            |.   :|.:|            .|||:..:  :..|:|..::..   .|.||.:.:|      |.
Zfish   302 PCRMQIPEQLELRIQQYLSQYPVEAEVQKLWDEEEHQSSSISTAADDYDEDEFITDAITSKPYRA 366

  Fly   112 QMQSQFRHILLVYLDFRQTEKFQRIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKS 176
            ....:..|     |..|....::|:...|..:  ||:...::.:.||:.:|:||:::|:|||||:
Zfish   367 LEPKEAEH-----LSQRLLSMWKRVGPARGAE--LPVDAHKESILEAVRSSQVVVISGETGCGKT 424

  Fly   177 TQVPQYLYDFGYR-------SIACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLT 234
            |::|::|.:.|..       ::..|||||::.||:.:|||||:.......|.:|:|.|....:.:
Zfish   425 TRIPRFLLEDGVLRGEGAECNVLVTQPRRISAVSVAQRVAHEIGPALQHCVGYQVRLESRPPERS 489

  Fly   235 N--ILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSAT 297
            .  :||:|.|:||::|.....|:....:|:||:|||::..|.||.:.:|:|..||:||::||||:
Zfish   490 GGALLFLTLGVLLKKLQSNPRLEGISHVIVDEVHERDVQTDLLLHLLRCVLSLRPELKVLLMSAS 554

  Fly   298 INVELFHGYFGEEGARLVQVPGRLFPIKLRYLPP-------PALELKAGQATSK-----RSQRNR 350
            .:.:....|||  |..:::|||.:.|::.|:|..       |.|::.:.|.:::     ..:.|.
Zfish   555 GDSQRLAQYFG--GCPVLRVPGFMHPVRARFLEDMQLDSRRPLLDMGSTQWSAEVRGRMGKEENN 617

  Fly   351 IDPAPFVQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHE-YATEQTHWLVLPLHSGQAIA 414
            :.| ....|..:||..:.|.|.|.||.|:.|..||::|.:.:.| .|......::|||||..|::
Zfish   618 VTP-DLDLVADVIDHIHRTGEPGAVLCFLPGWQEIKAVQQQLEEKQAYRSGSQIILPLHSSMAVS 681

  Fly   415 DQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSA 479
            :|..||...|.|.||.:::|||||||:|:|.:..|||:|..||.|:|...|...|...|:|:::.
Zfish   682 EQQVVFQRPPAGQRKIVLATNIAETSITIDDIVHVVDAGVQKEQNYDPRTKVSALNTVWISQANV 746

  Fly   480 DQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPF----I 540
            .||:|||||..||..:.|:..:|....|.:|.|||.|.||:::::| ..:..|:.:|..|    :
Zfish   747 TQRRGRAGRCQPGHSYHLFPRKQLERMEPFPVPEILRTPLESVVMQ-AKIHCPESKAEDFLSQVL 810

  Fly   541 EAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAM 605
            ::|:|:.:...:..|.....|...|.:||||..::.:..:..:||:|:..::|..|:.:|::.|.
Zfish   811 DSPDTQAVRTAVKNLMDIGVLDASEDLTPLGHHVSCMSCDPRLGKVLVFSALFSCVQPVLSVVAC 875

  Fly   606 LSVQNPLTNRAHTDQRCVRERESLESDHG-DLFTLVRLYNVWVQLKMRRDGTRQWCRRLGIEEQR 669
            |: ::|..|.........:.:..|....| |.....|:...|.: :..||..:.:..:..:....
Zfish   876 LT-RDPFYNSLQNRTLVSKAKAELSGSSGSDYLVFSRVVQSWRE-QHSRDSRQDYLDKHTLSGAS 938

  Fly   670 FYEVTKLRQQFQRILESCGMVVASDSDSQLTSAERATRHGELRQLKAMKRRQRFEQ--------- 725
            ...:..|.|||...|...|:|   |..::.           ||....:.::.:.||
Zfish   939 LRFIHGLMQQFSDNLCEAGLV---DHSAEC-----------LRLSSPVNQQSKEEQLITAVLLAG 989

  Fly   726 --PRQRKLLKQSAGRVAEDEEEQEEAQGDDMRDVDFRLRFDPRQLALLERSSRLDRHSVVVLLKL 788
              |   .|::...|.|.:....:.|       :|.||....|   .||.||| ::|....:..:.
Zfish   990 LYP---NLIQVKKGVVTKSGRFRAE-------NVSFRTESGP---VLLHRSS-VNRDKQHLWSRW 1040

  Fly   789 LLGSGFYPQLAISDEFNYCKGGGQQFFHTRLKPFVLQHPNSQFAKHFELLKLTESDLLPK--PDF 851
            |            ..|:..|..||.|    ::...:.||       ..||.||:.||..:  .|.
Zfish  1041 L------------TFFSAVKSSGQVF----IRDSTVVHP-------LALLLLTDCDLSERVVGDR 1082

  Fly   852 YTPKLPLSKRHQLLCYQSLLETAKPYLINCIRLPAAQTLLLFSFAIDTNAGITQIACDGWLGLDL 916
            ....||                 .|.||.....||...||                   |
Zfish  1083 VEVALP-----------------GPALIRWEFSPAVWELL-------------------W----- 1106

  Fly   917 PMPGSGMELLRRAIELRRRWSRLLYDKLDDLKSKQESPSHSSDDRSSALWQDLVDYM 973
                          :||.....::|.||    .:.|..|.|...:.|.|...|||.:
Zfish  1107 --------------DLRASIQAMIYRKL----RQSECKSSSEQRKDSELIDLLVDLL 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	66/180 (37%)
		DEXDc	163..298	CDD:238005	55/143 (38%)
		Helicase_C	358..490	CDD:278689	56/132 (42%)
		HA2	560..640	CDD:214852	19/80 (24%)
		OB_NTP_bind	<792..897	CDD:285018	23/106 (22%)
dhx30	XP_021322211.1	HrpA	371..>929	CDD:224557	178/570 (31%)
dhx30	XP_021322211.1	OB_NTP_bind	947..1069	CDD:311586	36/172 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820