DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32533 and DHX33

DIOPT Version :10

Sequence 1:NP_728244.1 Gene:CG32533 / 32933 FlyBaseID:FBgn0052533 Length:1139 Species:Drosophila melanogaster
Sequence 2:NP_064547.2 Gene:DHX33 / 56919 HGNCID:16718 Length:707 Species:Homo sapiens


Alignment Length:581 Identity:205/581 - (35%)
Similarity:314/581 - (54%) Gaps:40/581 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 QRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS---IACTQPRRLACVSL 204
            :|:|||.:.|..|...|......::.|:||.||:||:|||||:.|...   ||.|||||:|.:||
Human    71 RRSLPIFQARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYEGGISRQGIIAVTQPRRVAAISL 135

  Fly   205 CKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERN 269
            ..||:.|...:.|..|.:.:||:...::.|.|.|:|:|:|||:....:.|.:|..:||||.|||.
Human   136 ATRVSDEKRTELGKLVGYTVRFDDVTSEDTRIKFLTDGMLLREAISDSLLRKYSCVILDEAHERT 200

  Fly   270 LFGDFLLGVTKCLLRARPQ-----LKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYL 329
            :..|.|.||.|...:.|.:     ||:|:||||::|:||..||  .||.::.:.||..||::.|.
Human   201 IHTDVLFGVVKAAQKRRKELGKLPLKVIVMSATMDVDLFSQYF--NGAPVLYLEGRQHPIQVFYT 263

  Fly   330 PPPALELKAGQATSKRSQRNRIDPAPFVQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHE 394
            ..|               :|....|..|.|.. |.|:.|:|:  |:|:|::|..|||::.:...:
Human   264 KQP---------------QNDYLHAALVSVFQ-IHQEAPSSQ--DILVFLTGQEEIEAMSKTCRD 310

  Fly   395 YATEQTH----WLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKV 455
            .|.....    .|||||::....|.|.:||..||:|.||.|:||||||||:|:.|:::|||:|.|
Human   311 IAKHLPDGCPAMLVLPLYASLPYAQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMV 375

  Fly   456 KEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLD 520
            |...::.....:.|....|||:.|.||.|||||...|:|:||||.:::..|:....|||.|..|.
Human   376 KAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYRLYTEDEFEKFDKMTVPEIQRCNLA 440

  Fly   521 TMLLQMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCALSVEE---KITPLGRSLANLPVELS 582
            :::||:::|.:|:|..|.|:..|..:.|:..|..|....||..::   .:||:||.:|..|:|..
Human   441 SVMLQLLAMKVPNVLTFDFMSKPSPDHIQAAIAQLDLLGALEHKDDQLTLTPMGRKMAAFPLEPK 505

  Fly   583 IGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTDQRCVRERESLESDHGDLFTLVRLYNVWV 647
            ..|.:||...|...|::||:.::|||.:.|.|.....:.....|:...|..||..||:.:|..:.
Human   506 FAKTILMSPKFHCTEEILTIVSLLSVDSVLHNPPSRREEVQGVRKKFISSEGDHMTLLNIYRTFK 570

  Fly   648 QLKMRRDGTRQWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVASDSDSQLTSAERATRH 708
            .|    .|.:.||:...:..:....|.::|.|.:.|.....|.:|| |...:.|..|...|
Human   571 NL----GGNKDWCKENFVNSKNMTLVAEVRAQLRDICLKMSMPIAS-SRGDVESVRRCLAH 626

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32533NP_728244.1 HrpA 145..>619 CDD:441249 182/488 (37%)
OB_NTP_bind 792..897 CDD:400182
DHX33NP_064547.2 Required for nucleolar location. /evidence=ECO:0000269|PubMed:26100019 1..80 4/8 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..64
HrpA 73..>700 CDD:441249 204/579 (35%)
DEAH box 194..197 2/2 (100%)
HA2, required for interaction with EIF3G and RPL26. /evidence=ECO:0000269|PubMed:26100019 471..562 27/90 (30%)
Critical for rDNA-binding. /evidence=ECO:0000250 547..558 2/10 (20%)
Blue background indicates that the domain is not in the aligned region.

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