DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32533 and dhx9

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_001188373.1	Gene:	dhx9 / 568043	ZFINID:	ZDB-GENE-070912-171	Length:	1270	Species:	Danio rerio

Alignment Length:	1141	Identity:	285/1141 - (24%)
Similarity:	455/1141 - (39%)	Gaps:	336/1141 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DHKAELVGLLQAKSRQVGRSLVENEADFWK----------------FVGKYEAMMRSTGQ----- 72
            ||....:..:....||:||.:...|....|                .:|..||.   |||
Zfish   213 DHNRSFIAEMTIFVRQLGRRVTAREHGSTKKLAAQSCALSLVRQLYHLGVIEAY---TGQTKKKE 274

  Fly    73 -------PV--------------------LPP---------RLAEAELSSMQPYHRSKHLAL--- 98
                   ||                    :||         .|.:.:|:..:|..|.....:
Zfish   275 GESVDVYPVNVNDDVQHQLYSVVQELGIHIPPPPQDPNSPVSLVQGKLAHFEPSQRQSMAGVVPW 339

  Fly    99 -------------RLDADELLQEARDQMQSQFRHILLVYLDFRQTEKFQRIRKLRQTQRNLPIAR 150
                         .:|...|.....:|:.:.    ||..|:: |.|:.|.::.:...:..||:..
Zfish   340 SPPQVNWNPWTSSNIDEGPLAFCTPEQISND----LLNELNY-QLEQDQNLQTILTERSQLPVKN 399

  Fly   151 FRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD---FGYRSIAC----TQPRRLACVSLCKRV 208
            |::.:...:..:.|||:.|.|||||:||||||:.|   .|.|:..|    |||||::.||:.:||
Zfish   400 FQEQIMSTIYNNPVVIIRGATGCGKTTQVPQYILDEFIKGGRASDCNIVVTQPRRISAVSVAERV 464

  Fly   209 AHELLDDYGSRVAFQIRFERSRTK-LTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFG 272
            :.|..:|.|....:.:|||....: ..:|||.|.|:|||:|  .:.:.....:|:||||||::..
Zfish   465 SFERGEDVGKSCGYSVRFESFLPRPHASILFCTVGVLLRKL--ESGIRGISHVIVDEIHERDINT 527

  Fly   273 DFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIK----------LR 327
            ||||.|.:.:::|.|.:::|||||||:..:|..||  ....:::|.||..|::          .:
Zfish   528 DFLLVVLRDVVQAYPDVRVILMSATIDTTMFKEYF--FNCPVIEVHGRAHPVQEYFLEDCIQMTQ 590

  Fly   328 YLPPPALELK------------------AGQATS---KR--SQRNRIDPAPFVQVLSLIDQQYPT 369
            ::||| ::.|                  .|...|   ||  ||.|..:.: |..:.:|:......
Zfish   591 FVPPP-MDRKRKDKDDEGGDEDVNCNVICGSEYSPETKRAMSQLNEKETS-FELIEALLKYIETL 653

  Fly   370 SERGDVLIFVSGVNEIESVVEAV--------HEYATEQTHWLVLPLHSGQAIADQSKVFDYAPEG 426
            ...|.||:|:.|.|.|.|:.:.:        |:|.       :|||||.....:|.:||:..|:|
Zfish   654 EVPGAVLVFLPGWNLIYSMQKHLEMNPHFGGHQYR-------ILPLHSQIPREEQRRVFEPVPDG 711

  Fly   427 MRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGP 491
            :.|.|:||||||||:|::.|.||:||.|.|...|.:..........|.||::.:||||||||..|
Zfish   712 VTKVILSTNIAETSITINDVVFVLDSCKQKVKLFTSHNNMTNYATVWASKTNLEQRKGRAGRVRP 776

  Fly   492 GVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAF--PFIEAPETERIEQTILA 554
            |.||.|.:..::...|.:.||||:|.||..:.|.:..:.|..:..|  ..||.|..:.:.:....
Zfish   777 GFCFHLCSRARFEKLETHMTPEIFRTPLHEVALSIKLLRLGGIGNFLSKAIEPPPLDAVIEAEHT 841

  Fly   555 LKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNR---- 615
            |::..||...:::|||||.||.||:|..:|||::||.:|...:.:.|::|......|..:.
Zfish   842 LRELDALDSNDELTPLGRILAKLPIEPRLGKMMIMGCIFNVGDAVCTISAATCFPEPFISEGKRL 906

  Fly   616 --AHTDQRCVRERESLESDHGDLFTLVRLYNVWVQLKM-RRDGTRQWC--RRLGIEEQRFYEVTK 675
              .|        |....|...|...|:.::..|.:::: ..|...::|  :||.:...|.....|
Zfish   907 GFVH--------RNFAGSRFSDHVALLSVFQAWDEVRVGGEDAEIRFCEHKRLNMPTLRMTWEAK 963

  Fly   676 LRQQFQRILESCGMVVASDSDSQLTSAERATRHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVA 740
            :  |.:.||.:.|.                                     .:..||.|....|.
Zfish   964 V--QLKEILVNVGF-------------------------------------PEECLLNQVFNNVG 989

  Fly   741 EDEEEQEEAQGDDMRDVDFRLRFDPRQLALLERSSRLDRHSVVVLLKLLLGSGFYPQLAISDEFN 805
            .|                                :.||      |:..||..|.||        |
Zfish   990 PD--------------------------------NNLD------LVISLLTFGSYP--------N 1008

  Fly   806 YCKGGGQQFFHTRLKPFV-------LQHP---NSQFAKHFELLKLTESDL-LPKPDF-YTPKLPL 858
            .|       :|...:..:       |.|.   |..|:.|         || .|.|.| :..|:
Zfish  1009 VC-------YHKEKRKILTTEGRNALIHKSSVNCPFSNH---------DLKYPSPFFVFGEKI-- 1055

  Fly   859 SKRHQLLCYQSLLETAKPYLINCIRLPAAQTLLLFSFAIDTNAGITQIACDGWLGLDLPMP-GSG 922
              |.:.:..:|:.      |::.::|     :|..|..|.:|..:.::  |.|:.|.:|.. .:|
Zfish  1056 --RTRAISAKSMT------LVSPLQL-----ILFGSKKITSNGEVVEL--DDWIKLQIPHDVAAG 1105

  Fly   923 MELLRRAIELRRRWSRLLYDKLDDLKSKQESPSHSSDDRSSALWQDLVDYMALDVAYAIRRLLP- 986
            :..||..:|.                                    ||..:..|..| ||.|.|
Zfish  1106 VAGLRAGLEA------------------------------------LVVEVTKDPEY-IRNLDPL 1133

  Fly   987 ----ADIKRLYTHQAPSARLAELKENPFAVDFPMTP 1018
                .::.||.:..: ||.:..:..||...|.|..|
Zfish  1134 NERLLNVIRLVSRPS-SAGINLMASNPRFGDGPRPP 1168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	71/189 (38%)
		DEXDc	163..298	CDD:238005	62/142 (44%)
		Helicase_C	358..490	CDD:278689	51/139 (37%)
		HA2	560..640	CDD:214852	25/85 (29%)
		OB_NTP_bind	<792..897	CDD:285018	23/116 (20%)
dhx9	NP_001188373.1	DSRM	5..69	CDD:214634
		DSRM	188..258	CDD:214634	8/44 (18%)
		DEXDc	400..580	CDD:214692	72/183 (39%)
		DEXDc	413..553	CDD:238005	62/141 (44%)
		Helicase_C	641..774	CDD:278689	50/139 (36%)
		HA2	844..925	CDD:214852	25/88 (28%)
		OB_NTP_bind	965..1079	CDD:285018	36/227 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920