DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32533 and ythdc2

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	XP_021332046.1	Gene:	ythdc2 / 567114	-ID:	-	Length:	1381	Species:	Danio rerio

Alignment Length:	1278	Identity:	299/1278 - (23%)
Similarity:	458/1278 - (35%)	Gaps:	427/1278 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EFSFLDHKAELVGLLQAKSRQVGRSLVENEADFWKF--VGKYEAM--MRSTGQPVLPPRLAEAEL 84
            |.:|:...|:.:|.: :|||..|.|         :|  |.|.:.|  .||:....|.|.......
Zfish    64 ERAFIHRLAQSLGYI-SKSRGKGCS---------RFLTVRKKDGMEAQRSSMSCSLSPSCRALVQ 118

  Fly    85 SSMQ--PYHRSKHLALRLDADELLQEARDQMQSQFRHILLVYLDFRQTEKFQRIRKLRQT----- 142
            |.||  |....:...|:..|:..||...|...|:.|      ...|.:....::...|.:
Zfish   119 SLMQRFPISSRERSQLQPHAERGLQSPPDTTDSKSR------TSGRLSHGIPQVPPRRSSAPELD 177

  Fly   143 --QRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS-----IACTQPRRLA 200
              ::.||:...::.:.:::...:||:|.|:||.||:||:||:|.|....:     |.||||||||
Zfish   178 AFRKALPVYELQEQIIQSIRDHQVVLVLGETGSGKTTQIPQFLLDDCSATASPCRIFCTQPRRLA 242

  Fly   201 CVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAAN-LDQYDALILDE 264
            .:::.:|||.|..::.|..|.:|||.|...:..|.:.|.|.|:|||.|..... |.....:|:||
Zfish   243 TIAVAERVAAERGENIGQTVGYQIRLESRVSPKTLLTFCTSGVLLRTLMAGDEALSTVTHVIVDE 307

  Fly   265 IHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYL 329
            :|||:...||||...|.:|:..|.|:|:|.||.::|.||..|||  ...::.:.|..:.:|..:|
Zfish   308 VHERDGLTDFLLTKMKEVLQKMPNLRLVLSSAALDVSLFMRYFG--SCPVIHIKGCPYEVKQLFL 370

  Fly   330 -------------------------------------------PP-------------------- 331
                                                       ||
Zfish   371 EDILRSTAYTNKDMIKYKKEAQKEESQQCSLSEWCERDVPQADPPERPTVCVLQDNQLLDDGGDS 435

  Fly   332 ------------------------------------------------------------PALEL 336
                                                                        .||.:
Zfish   436 VFSQMSEKDVSSLEPWLLREMDSCISSIFLNQDADAFTQLFNLILNENISVDYRHSETSATALMV 500

  Fly   337 KAGQATSKRSQR-------------------------------------------NRIDPAPFVQ 358
            .||:.....:::                                           :..|.|..:|
Zfish   501 SAGRGFVSHTEQLLNMGANINIKASNGWTALDWAKHFKQTEAVDLLESHIWCAEASPQDEASLLQ 565

  Fly   359 ------------------------------VLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAV- 392
                                          :|.|:.....:|::|.||||:.|.:||.|:.:.:
Zfish   566 NSSCELSCEDQELLKAYHHSFDDEKVDLQLILHLLHSICQSSDQGAVLIFLPGYDEIVSLRDQIL 630

  Fly   393 ---HEYATEQTHWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGK 454
               ..:...|..:.|..|||....:||.||....|:|:||.|:||||||||:||..|.||:||||
Zfish   631 FDDKRFTEHQQRFQVFVLHSSMQTSDQKKVLKSTPKGVRKIILSTNIAETSITVSDVVFVIDSGK 695

  Fly   455 VKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPL 519
            |||..:||......||..|:||:||.||||||||..|||||.|::..:::....:..|::.|:||
Zfish   696 VKEKAYDALNNVTMLKMVWISKASALQRKGRAGRCRPGVCFHLFSRLRFSNMLEHQIPQLLRMPL 760

  Fly   520 DTMLLQMVSMGLPDVRAFPFI----EAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVE 580
            ..:.|....:...:.....|:    |.|....::..:..||...|:...|.:|.||..||:||||
Zfish   761 QELCLHTKLLAPINCPVAEFLSRAPEPPHINTVKHAVQMLKTIDAMDPWENLTELGLHLADLPVE 825

  Fly   581 LSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTDQRCV----RERESLE--SDHGDLFTL 639
            ..:|||:|...|...::.:||:|..|:.:.|....|...||.|    |.|.:..  |||   ..|
Zfish   826 PHLGKMVLCAVVLKCLDPVLTIACTLAHREPFVLPAQAAQRRVAMLCRRRFTANTFSDH---MAL 887

  Fly   640 VRLYNVWVQLKMRRDGTRQWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVASDSDSQLTSAER 704
            :|.:..|  .|.|.||   |       |:.|.|...|.|....|:.|.                |
Zfish   888 LRAFQAW--QKARSDG---W-------ERAFCEKNFLSQATMEIIVSM----------------R 924

  Fly   705 ATRHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEEQEEAQGDDMRDVDFRLRFDPRQLA 769
            ....|:||....::.|                             .|.|:|||
Zfish   925 TQLLGQLRATGFVRAR-----------------------------GGGDIRDV------------ 948

  Fly   770 LLERSSRLDRHSVVVLLKLLLGSGFYPQLAISDEFNYCKGGGQQFFHTRLKPFVLQHPNSQFAKH 834
                :...:..:||   |..|.:|.||.|...|..:.   .|::....||      ||.|
Zfish   949 ----NQNSENWAVV---KAALVAGMYPNLIHRDGLSL---SGEKEKKVRL------HPTS----- 992

  Fly   835 FELLKLTESDLLPKPDFYTPKLPLSKRH---------QLLCYQSLLETAKPYLINC--------- 881
                      :|.:|.:  .|:|.:...         ..|.|..:....:...:.|
Zfish   993 ----------VLSQPQY--KKIPPANGQAAAVDSLPTDWLIYDEMTRAHRIASVRCCTAVTPLTI 1045

  Fly   882 ------IRLP--AAQTLLLFSFAIDTNAGITQIAC---------DGWLGLDLPMPGSGMELLRRA 929
                  .:||  |.|..:|...:.|::....:..|         |.|:...|     ..|.....
Zfish  1046 ALFGGGAKLPSSALQEAVLQRGSADSSDSEVEDQCSARQAHLTLDHWINFRL-----DPETAELV 1105

  Fly   930 IELRRRWSRLLYDKLDDLKSKQESPSHSSDDRSSALWQDLVDYMALDVAYA----------IRRL 984
            ..||:||..:...::       .|||.:......:..:.||..::.:...|          ..|.
Zfish  1106 FGLRQRWQSVFLRRI-------RSPSKACSQLDESTIRTLVSVLSAEEQSAGLQQPTGIGQRPRP 1163

  Fly   985 LPADIKRLYTH-------------QAPSA-----RLAELKENP 1009
            :.|:....|||             |..:|     |||...:||
Zfish  1164 VSAEDSSSYTHTHGRSRNTADTPQQEATASPDRPRLASQLKNP 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	68/177 (38%)
		DEXDc	163..298	CDD:238005	60/140 (43%)
		Helicase_C	358..490	CDD:278689	64/165 (39%)
		HA2	560..640	CDD:214852	30/85 (35%)
		OB_NTP_bind	<792..897	CDD:285018	23/130 (18%)
ythdc2	XP_021332046.1	R3H_DEXH_helicase	36..94	CDD:100077	11/39 (28%)
		HrpA	169..>1001	CDD:224557	232/938 (25%)
		ANK repeat	496..524	CDD:293786	4/27 (15%)
		YTH	1248..1379	CDD:309322
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920