DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32533 and dhx57

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	XP_001921063.3	Gene:	dhx57 / 555250	ZFINID:	ZDB-GENE-030131-4078	Length:	1431	Species:	Danio rerio

Alignment Length:	1155	Identity:	303/1155 - (26%)
Similarity:	480/1155 - (41%)	Gaps:	317/1155 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LIEFSFLDHKAELVGLLQAKSRQVGRSL---VENEADFWKFVGKYE--AMMR----------STG 71
            |:.||..|......|.|.......|:||   .|.|...:..:...|  ..:|          |..
Zfish   390 LVAFSSTDESLSGAGRLSVTEYLFGQSLSAAEEGEPVVYTLISSLEEDGPVRELLSAAHHKYSAP 454

  Fly    72 QPVL-PPRLAEAELSSMQ----------------------PYHR--SKHLA--LRLDADELLQEA 109
            .||| ||.:..|:..|.:                      ..||  .|.:|  |..|.|::..|.
Zfish   455 PPVLAPPTVTPAKSRSNKINVDNRTSATRDQSTSTSISEITNHRVKQKEVAQILSEDIDDVQDEG 519

  Fly   110 RD------------------------------QMQSQFRHILLVYLDFRQTEKFQRIRKLRQTQR 144
            .|                              |||.:.:.:.   .:|::....:|...:::.::
Zfish   520 DDEDEEECIPVENESYVNLRKRMVKKTEIRTEQMQEENKKLC---REFKRKRSSRRYISMQEQRQ 581

  Fly   145 NLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYR--------SIACTQPRRLAC 201
            .||..:.|:.:.|.|..::|::::|.|||||:||:||::.|...:        :|.||||||::.
Zfish   582 KLPAWQKREAILECLVKNQVLVISGMTGCGKTTQIPQFILDNFLQTGRPDRVANIICTQPRRISA 646

  Fly   202 VSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIH 266
            :::..|||.|..:..|....:|||.|..|:.:|.::|.|.|:|||:|.....|.....:|:||:|
Zfish   647 IAVATRVAQERAEALGHSTGYQIRLETVRSSITRLMFCTTGVLLRRLEGDPELSGVTHVIVDEVH 711

  Fly   267 ERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPI------- 324
            ||....||||.|.|.|:..|..||:|:||||:|.|||..||  .....:.:|||.||:
Zfish   712 ERTEESDFLLLVLKDLIVKRTDLKVIMMSATLNAELFSQYF--NNCPCIHIPGRTFPVEQFFLED 774

  Fly   325 ---KLRYL----------------PPPALELKAGQA--------------TSKRSQRNRIDPAPF 356
               |.||:                ..|..:...|:|              ||.|::.:..|..|.
Zfish   775 AIAKTRYVIEDGSPYRRSTKLNRSSGPGGKTGKGRALVEDFDDDYGGWSFTSFRNKESVKDSVPD 839

  Fly   357 VQ---------------------------------VLSLI------DQQYPTSERGDVLIFVSGV 382
            .|                                 |.||:      |..||.   |.||:|:.|:
Zfish   840 QQLSQQDLTVRYSNYSKSVVKTLAAMDLDKINMDLVESLLEWIVDGDHSYPP---GAVLVFLPGL 901

  Fly   383 NEIESVVEAVHE---YATEQTH-WLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTV 443
            .||:.:.|.:..   :...:|: .:|.||||..:..:|..||.....|:.|.|:||||||||:|:
Zfish   902 AEIKQLYEQLQSNRMFNNRRTNRCVVYPLHSSLSNEEQQAVFTRPQNGVTKIIISTNIAETSVTI 966

  Fly   444 DGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQY-NAFE 507
            |.|.:|:|||::||..:||:...:.|::.|||:::|.||||||||...||||.|:|:.:: :...
Zfish   967 DDVVYVIDSGRMKEKRYDASRSMESLEDVWVSRANALQRKGRAGRVASGVCFHLFTSHRFEHHLS 1031

  Fly   508 AYPTPEIYRVPLDTMLLQM----VSMGLPDVRAFPFIEAPETERIEQTILALKQH-CALSV---E 564
            ....|||.||||:.:.|::    |....|....|..:..|.|   |.::.|.||. |||..   |
Zfish  1032 QQQLPEIQRVPLEQLCLRVKVLEVFAERPLDSVFSQLIEPPT---EGSLEAAKQRLCALGALTDE 1093

  Fly   565 EKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTDQRCVRERESL 629
            |.:||||..||.|||::.|||::|:|::|..::..||:||.|:.::|..  :..|:|.....:.|
Zfish  1094 ESLTPLGWHLACLPVDVRIGKLMLLGAIFRCLDPALTIAASLAFKSPFV--SPWDKREEANEKKL 1156

  Fly   630 -----ESDHGDLFTLVRLYNVWVQLKMRRDGTR---QWCRRLGIEEQRFYEVTKLRQQFQRILES 686
                 .|||   ..|::.|..|  ....:.|.:   |:||...:..:...|:..|::||..:|..
Zfish  1157 GFSLANSDH---LALMQAYKGW--CNAAQSGFKAGYQYCRENFLSIRGLQEIACLKRQFAELLSD 1216

  Fly   687 CGMVVASDSDSQLTSAERATRHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEEQEEAQG 751
            .|.|                :.|    |||                     ||.    |:..::|
Zfish  1217 IGFV----------------KDG----LKA---------------------RVI----EKMSSKG 1236

  Fly   752 DDMRDVDFRLRFDPRQLALLERS---SRLDRHSVVVLLKLLLGSGFYPQL--AISDEFNY---CK 808
            .|               .:||.:   :.|:..: ..|:..:|.:..||.:  ..|.:..|   .|
Zfish  1237 SD---------------GVLEATGYEANLNSDN-TKLMSAMLCAALYPNVVQVRSPQMKYKLTSK 1285

  Fly   809 G-------GGQQFFHTRLKPFVLQHPNSQFAKHFELLKLTESDLLPKPDFYTPKLPLSKRH---Q 863
            |       ..:|.|.|:....|..||:|                          :..|.||   .
Zfish  1286 GAMKMQPKAEEQRFMTKSDGAVHIHPSS--------------------------VNFSVRHYDSP 1324

  Fly   864 LLCYQSLLETAKPYLINCIRLPAAQTLLLF---SFAIDTNAGITQIAC-DGWLGLDLPMPGSGME 924
            .|.|...::|::.::.:| .:.....::||   ...::...|...|:. |||    :....:..|
Zfish  1325 YLVYHEKVKTSRVFIRDC-SMVCVYPMVLFGGGQVNVELQRGQFIISLDDGW----IKFAAASHE 1384

  Fly   925 LLRRAIELRRRWSRLLYDKLDDLKSKQESPSHSSDDRSSALWQDLVDYMA 974
            :.....|||....:||.:|:     |..|....|..|.|.:...:|..::
Zfish  1385 VAELVKELRWELDQLLEEKI-----KNPSMDLISCPRGSRIIHTIVSLIS 1429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	73/189 (39%)
		DEXDc	163..298	CDD:238005	58/142 (41%)
		Helicase_C	358..490	CDD:278689	59/174 (34%)
		HA2	560..640	CDD:214852	31/87 (36%)
		OB_NTP_bind	<792..897	CDD:285018	22/122 (18%)
dhx57	XP_001921063.3	UBA_like_SF	199..240	CDD:328731
		MOT2	<310..511	CDD:227502	26/120 (22%)
		HrpA	538..1420	CDD:224557	272/996 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910