DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32533 and tdrd9

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_001123984.1	Gene:	tdrd9 / 553222	ZFINID:	ZDB-GENE-090313-193	Length:	1342	Species:	Danio rerio

Alignment Length:	813	Identity:	236/813 - (29%)
Similarity:	382/813 - (46%)	Gaps:	144/813 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD-FGYRSIAC----TQPRRLACVSLC 205
            |||.:.|::|...::.:.|||:.|.||.||:||:||::.| :..|:|.|    ||||::....:.
Zfish    89 LPITKNRQELVSLIENNSVVIIRGATGSGKTTQLPQFILDHYAERNIPCNLVVTQPRKIGATGIA 153

  Fly   206 KRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNL 270
            :.||.|.....||.|.:|:..|:..|:.|.::::|.|:||::|..:..|.:|..:.:||:|||:.
Zfish   154 RWVARERKCTLGSLVGYQVGLEKMATEHTKLIYVTTGVLLQKLVSSKTLTEYSHIFIDEVHERSE 218

  Fly   271 FGDFLLGVTKCLLRARPQ-LKLILMSATINVELFHGYFGE------EGARLVQVPGRLFPIKLRY 328
            ..||||.|.:.|||:..: :|:||||||||...|..|||.      ..|.:.:|.|..:.::..|
Zfish   219 ELDFLLLVVRKLLRSNSRYVKVILMSATINCIEFAEYFGSPIRNQMNPAYVFEVEGAPYAVEEYY 283

  Fly   329 LPPPALELKAGQATSKRSQRNRIDPAPFVQ------VLSLI--------------DQQYPTS--E 371
            |......|..|........::     |::.      .:|||              :|...|:  |
Zfish   284 LDELKTMLPVGVNLDLTLPQD-----PYITEEMYNVAVSLIQSFDEMEAKDHRRSEQTGSTTHPE 343

  Fly   372 RGDVLIFVSGVNEIESVVEAVHEYATEQTHWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNI 436
            ||.||:|:.|:.||:.:.||:.:...::..  |.||||...:.:|:.||.....|.||.|:||||
Zfish   344 RGSVLVFLPGLAEIQYMKEALSKLVRKRLQ--VYPLHSTVTLEEQNGVFLVPVPGYRKIILSTNI 406

  Fly   437 AETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAE 501
            ||:|:||..|::|:|...|:::..|.....:.|:..|.||:|.:||:|||||...|.|:||.|..
Zfish   407 AESSVTVPDVKYVIDFCLVRQLACDKETNYRCLRITWASKTSCNQRRGRAGRVSKGFCYRLVTRH 471

  Fly   502 QY-NAFEAYPTPEIYRVPLDTMLL--QMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCALSV 563
            .: |....:..||:.|.||.:.||  :::.||.|.......:..|....||:|:|.|||..||||
Zfish   472 FWENEIPNFSIPEMLRSPLASTLLKVKLLDMGDPRSVLSTALTPPILGDIERTVLQLKQIGALSV 536

  Fly   564 EEK--------ITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTDQ 620
            :..        :|.|||.||.|||:|.:||::::|.||..:|:.|.:||.||:::.....:....
Zfish   537 QSNSQRQFDGDLTFLGRVLAQLPVDLQLGKLIVLGHVFGCLEECLIIAASLSLKSFFAMPSLQQL 601

  Fly   621 RCVRERESL-ESDHGDLFTLVRLYNVWV------QLKMRRDGTRQWCRRLGIEEQRFYEVTKLRQ 678
            ...|.:.|. ::...|....|..:..|.      :|:..:| ..:|.:...|:.:|..||.:|.:
Zfish   602 AGYRSKLSFAQNVPSDFIAYVNAFKAWYTSRAKGELRHPKD-ELEWGKENCIQIKRIREVAELFE 665

  Fly   679 QFQRILESCGMVVASDSD-SQLTSAERATRHGELRQLKAMKRRQRFEQPRQRKLLKQ-------- 734
            ..::.:....|.::|.|: :..||..                       :||.:|:.
Zfish   666 DLKKRVSRFNMHISSSSNPTDYTSLH-----------------------KQRFILQVVIAGALFP 707

  Fly   735 ---SAGRVAEDEEEQEEAQGDDMRDVDFRLRFDP------RQLALLER------SSRLD------ 778
               |.|.: :::...:|..|:|.:.........|      :||..|.|      |...|
Zfish   708 NYFSQGEI-DEQLASKELSGNDPKTTILIRNLPPFAFLCYKQLQSLFRQCGQVKSIAFDGSRAYV 771

  Fly   779 -------RHSVVV--LLKLLLGSGFYPQLAI----SDEFNYCKGGGQQFFH---TRLKPFVLQHP 827
                   |.|.|:  :|..||.|...|.|.:    :||..: ...|:...|   ||:...|..|.
Zfish   772 EFHRSCVRESGVLHEVLLALLRSRHTPALHLQVHHADEVEF-HAKGKPIAHLRYTRVNVDVQSHT 835

  Fly   828 NSQFAKHFELLKLTESDLLPKPDFYTPKLPLSK 860
            .|.       :.:..|.:.|:      |||.|:
Zfish   836 VSP-------VGVLSSSVNPE------KLPTSR 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	67/183 (37%)
		DEXDc	163..298	CDD:238005	56/140 (40%)
		Helicase_C	358..490	CDD:278689	54/153 (35%)
		HA2	560..640	CDD:214852	28/88 (32%)
		OB_NTP_bind	<792..897	CDD:285018	18/76 (24%)
tdrd9	NP_001123984.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..81
		DEXDc	84..262	CDD:214692	68/172 (40%)
		DEXDc	106..247	CDD:238005	56/140 (40%)
		DEAH box. /evidence=ECO:0000250\|UniProtKB:Q14BI7	211..214		2/2 (100%)
		Helicase_C	343..459	CDD:278689	48/117 (41%)
		HA2	530..622	CDD:214852	29/91 (32%)
		TUDOR	851..972	CDD:278965	3/5 (60%)
		TUDOR	905..954	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920