DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32533 and Dhx30

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	XP_006243888.1	Gene:	Dhx30 / 367172	RGDID:	1308888	Length:	1222	Species:	Rattus norvegicus

Alignment Length:	804	Identity:	233/804 - (28%)
Similarity:	382/804 - (47%)	Gaps:	113/804 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TQINLIEFSFLDHKAELVGL---------LQAKSRQVGRSLVENEA-----DFWKFVGKYE---- 64
            |..||::|..:..|.:|..|         ..||.|:  ::..||:|     ...|.:|..:
  Rat   289 TAKNLMQFHTVGTKTKLATLTLLWPCPMTFVAKGRR--KAEAENKAAALACKKLKSLGLVDRNNE 351

  Fly    65 ---------AMMRSTG------------QPVLPPRLAEAELSS-------MQPYHRSKHLALRLD 101
                     |.:|..|            :|:|  |..||.||.       :.|       .|||.
  Rat   352 PLTHAMYNLASLRELGETQRRPCTIQVPEPIL--RKIEAFLSHYPVDSSWISP-------ELRLQ 407

  Fly   102 ADELLQEARDQMQSQFRHILLVYLDFRQTEKFQRIRKLRQTQR----------NLPIARFRKDLR 156
            :|::|...:|............|:...:.|:.:..:.|.:..|          .||:...|..:.
  Rat   408 SDDILPLGKDSGPLSDPITGKPYMPLSEAEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTIL 472

  Fly   157 EALDTSRVVIVAGDTGCGKSTQVPQYLYD------FGYR-SIACTQPRRLACVSLCKRVAHELLD 214
            .|::...||:::|||||||:|::||.|.:      .|.| ::..|||||::.||:.:||:|||..
  Rat   473 SAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGP 537

  Fly   215 DYGSRVAFQIRFE-RSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGV 278
            .....|.||:|.| :...:...:||.|.|:|||:|....:|:....:|:||:|||::..||||.:
  Rat   538 SLRRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLIL 602

  Fly   279 TKCLLRARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYLPPPALELKAGQATS 343
            .|.|.|..|.|:|:|||||.:.|.|..|||  |..:::|||.::|:|..||.....:|...|...
  Rat   603 LKGLQRLNPALRLVLMSATGDNERFSRYFG--GCPVIKVPGFMYPVKEHYLEDILAKLGKHQYPH 665

  Fly   344 KRSQRNRIDPAPF-----VQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHE-YATEQTHW 402
            :.......|....     ..::..||.:   .|.|.:|.|:.|..||:.|.:.:.| ....::.:
  Rat   666 RHRHHESEDECALDLDLVTDLVLHIDAR---GEPGGILCFLPGWQEIKGVQQRLQEALGMHESKY 727

  Fly   403 LVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQ 467
            |:||:||...:.||..:|...|.|:||.:::|||||||:||:.:..|||||..||..:|...|..
  Rat   728 LILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHVVDSGLHKEERYDLKTKVS 792

  Fly   468 RLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLP 532
            .|:..|||:::..||:|||||...|..:.|:...:......:..|||.|.||:.::|| ..:.:|
  Rat   793 CLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQ-AKIHMP 856

  Fly   533 DVRAFPF----IEAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVF 593
            :..|..|    :::|..:.:::.::.|::...|...|.:|.||:.||::..:..:.|.:::.::|
  Rat   857 EKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIF 921

  Fly   594 PEVEQLLTLAAMLS---VQNPLTNRAHTDQRCVRERESLESDHG-DLFTLVRLYNVWVQLKMRRD 654
            ..:..||.:.:.|:   ..:.|.|||..|    :.:..|..|.| |....||....|.::...:|
  Rat   922 RCLHPLLVVVSCLTRDPFSSSLQNRAEVD----KVKALLSHDSGSDHLAFVRAVAGWEEVLRWQD 982

  Fly   655 GTRQWCRRLGIEEQRFYE-----VTKLRQQF-QRILESCGMVVASDSDSQLTSAERATRHGELRQ 713
            .|   .|...:||...|.     :..|.:|| :.|.|:  .:|...||..|.||:......|...
  Rat   983 RT---SRENYLEENLLYAPSLRFIHGLIKQFSENIYEA--FLVGKPSDCTLPSAQCNEYSEEEEL 1042

  Fly   714 LKAMKRRQRFE---QPRQRKLLKQ 734
            :|.:.....:.   |.||.|:.:|
  Rat  1043 VKGVLMAGLYPNLIQVRQGKVTRQ 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	74/179 (41%)
		DEXDc	163..298	CDD:238005	61/142 (43%)
		Helicase_C	358..490	CDD:278689	52/132 (39%)
		HA2	560..640	CDD:214852	21/83 (25%)
		OB_NTP_bind	<792..897	CDD:285018
Dhx30	XP_006243888.1	DEXDc	466..645	CDD:214692	73/180 (41%)
		DEXDc	480..621	CDD:238005	60/140 (43%)
		HELICc	714..813	CDD:197757	40/98 (41%)
		HA2	885..968	CDD:214852	21/86 (24%)
		OB_NTP_bind	1008..1130	CDD:285018	17/61 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820