DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32533 and pea

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster

Alignment Length:	972	Identity:	273/972 - (28%)
Similarity:	437/972 - (44%)	Gaps:	268/972 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KADEHASSRRRTQIN---------LIEFSFLDHKA-----ELVGLL---QAKSRQVGRSLVENEA 54
            :.|||.|.:|.|:|:         :|....||...     |..|||   :.....:...:||.|.
  Fly   403 EGDEHESRKRVTRISSPERWEIKQMISSGVLDRSEMPDFDEETGLLPKDEDDEADIEIEIVEEEP 467

  Fly    55 DFWKFVGK-------------------YEAMMRST------GQPVLPPRLAEAELSSMQ------ 88
            .|....|:                   ..|||:|.      .|.:|.   .|.|:.:|.
  Fly   468 PFLSGHGRALHDLSPVRIVKNPDGSLAQAAMMQSALSKERREQKMLQ---REQEIEAMPTSLNKN 529

  Fly    89 -----PYHRSKHLALRLDADELLQEARDQMQSQFRHIL------------LVYLDFRQTEKFQRI 136
                 |...|:.||..:..   :..|..::....:|::            |..::.||
  Fly   530 WIDPLPEDESRSLAANMRG---MAAAPPEVPEWKKHVIGGKKSSFGKKTDLTLVEQRQ------- 584

  Fly   137 RKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS---IACTQPRR 198
                    :|||.:.|.||.:|:..::::||.|:||.||:||:.|||.:.|:.:   |.||||||
  Fly   585 --------SLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTARGKIGCTQPRR 641

  Fly   199 LACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILD 263
            :|.:|:.||||.|.....|..|.:.||||...:..|.|.::|:|:|||:..:.|.|..|..::||
  Fly   642 VAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLD 706

  Fly   264 EIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRY 328
            |.|||.:..|.|.|:.|..::.||:||||:.|||::...|..||.:  |.:..:|||.||:::.|
  Fly   707 EAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFK--APIFTIPGRTFPVEVLY 769

  Fly   329 LPPPALELKAGQATSKRSQRNRIDPAPFVQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVH 393
                          :|..:.:.:| |..:.|:.:..::.|    ||:|:|::|..||::..|.::
  Fly   770 --------------TKEPETDYLD-ASLITVMQIHLREPP----GDILLFLTGQEEIDTACEILY 815

  Fly   394 E----YATEQTHWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGK 454
            |    ...:....::||::|......|:::||.||.|.||.:::|||||||||:||:.:|||.|.
  Fly   816 ERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGF 880

  Fly   455 VKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPT--PEIYRV 517
            ||:..:::......|....:|:::|.||.|||||||||..:||||...|.. |..||  |||.|.
  Fly   881 VKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRD-EMLPTPVPEIQRT 944

  Fly   518 PLDTMLLQMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCALSV---EEKITPLGRSLANLPV 579
            .|.|.:||:.:||:.|:..|.|::||.   :|..::||:|..:||.   |..:|.|||.:|..|:
  Fly   945 NLATTVLQLKTMGINDLLHFDFMDAPP---VESLVMALEQLHSLSALDDEGLLTRLGRRMAEFPL 1006

  Fly   580 ELSIGKMLLMGSVFPEVEQLLTLAAMLSVQN----PLTNRAHTDQRCVRERESLESDHGDLFTLV 640
            |.::.|||:|.......:::||:.:||||||    |...:|..||:..:..:: |.||   .||:
  Fly  1007 EPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQA-EGDH---LTLL 1067

  Fly   641 RLYNVWVQLKMRRDGTRQWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVASDSDSQLTSAERA 705
            .:||.|...|.    :..||          ||
  Fly  1068 AVYNSWKNNKF----SNAWC----------YE--------------------------------- 1085

  Fly   706 TRHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEEQEEAQGDDMRDVDFRLRFDPRQLAL 770
                ...|::.:||.|                               |:|          :||..
  Fly  1086 ----NFVQIRTLKRSQ-------------------------------DVR----------KQLLG 1105

  Fly   771 LERSSRLDRHSVVVL--------LKLLLGSGFYPQLAISDEFNYCKGGGQQFFHTRLKPFVLQ-H 826
            :     :|||.:.|:        ::..:.|||:...|..|.        |:.:.|.:...|:. |
  Fly  1106 I-----MDRHKLDVVSAGKNSVRIQKAICSGFFRNAAKKDP--------QEGYRTLVDSQVVYIH 1157

  Fly   827 PNS-------QFAKHFELLKLTE------SDLLPK------PDFY----TPKLPLSKRHQLL 865
            |:|       ::..:.||::.|:      :.:.||      |.|:    ..||...|::|.|
  Fly  1158 PSSALFNRQPEWVIYHELVQTTKEYMREVTTIDPKWLVEFAPSFFRFSDPTKLSKFKKNQRL 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	73/174 (42%)
		DEXDc	163..298	CDD:238005	61/137 (45%)
		Helicase_C	358..490	CDD:278689	49/135 (36%)
		HA2	560..640	CDD:214852	30/86 (35%)
		OB_NTP_bind	<792..897	CDD:285018	23/98 (23%)
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	239/796 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468083
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840