DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32533 and Dhx32

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_001123511.1	Gene:	Dhx32 / 361667	RGDID:	1311740	Length:	751	Species:	Rattus norvegicus

Alignment Length:	773	Identity:	187/773 - (24%)
Similarity:	330/773 - (42%)	Gaps:	154/773 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 RIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD------FGYRSIAC 193
            |..||.:.:..|||.:.:....|:|..::||:|:||:.||||:||||:..:      :.:..:.|
  Rat    58 RYYKLLKEREELPIWKEKYSFMESLLQNQVVLVSGDSKCGKSSQVPQWCAEYCLSIHYQHGGVIC 122

  Fly   194 TQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYD 258
            ||..:...|.|..|||.|:..:.|..|.:.|.||...|..|.:.:.|:.:|.|::.....|..|.
  Rat   123 TQVHKQTAVQLALRVADEMDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYG 187

  Fly   259 ALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFP 323
            .:|||::|||:|..|.|||:.|.:|.|||:||||:..:...:.....|:|  ...|::|..: .|
  Rat   188 VIILDDVHERSLATDVLLGLLKDVLLARPELKLIINCSPFLISRLSSYYG--NVPLLEVRNK-HP 249

  Fly   324 IKLRYLPPPALELKAGQATSKRSQRNRIDPAPFVQVLSLIDQQYPTSERGDVLIFVSGVNEIESV 388
            :::.||              ..:|::     ||..|:.||.:.:.:.|:|||::|::...:||..
  Rat   250 VEVVYL--------------SGAQKD-----PFESVVRLIFEIHRSGEQGDVVVFLACEQDIEKT 295

  Fly   389 VEAVHEYAT----EQTHWLVLPLHSGQAIADQSKVFDYAPEGMRKC-------IVSTNIAETSLT 442
            .|.|.:..:    :....:|:||:.    .::..:|....|..::|       :::|:..|:.:.
  Rat   296 YEIVCQEGSNLNPDVGELVVIPLYP----KEKCSLFRPVDETEKRCQASQRRVVLTTSCGESLIW 356

  Fly   443 VDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFE 507
            ...||||:|.|..:...::...:...|....:|:|.|:.||...|.:..|..|.||| |::.:.:
  Rat   357 SHTVRFVIDVGLERRQVYNPRIRANSLVLQPISQSQAEIRKQLLGSSPSGKLFCLYT-EEFASKD 420

  Fly   508 AYP--TPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCALSVEEKITPL 570
            ..|  ..|:....|.:|:|.|..:.:..:....|:..|..|.:.|.:..|....||..:..::..
  Rat   421 MRPLKPAEMQEANLTSMVLFMKRVDIAGLGRCDFMNRPAPESLMQALEDLDYLAALDNDGNLSEF 485

  Fly   571 GRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAH-TDQRCVRERESLESDHG 634
            |..::..|::..:.|.:|....|..|:::||:|||::..:...:..| .::..|...::.....|
  Rat   486 GIIMSEFPLDPQLSKSILASCEFDCVDEMLTIAAMVTAPSCFLHVPHGAEEAAVTCWKTFLHPEG 550

  Fly   635 DLFTLVRLYNVWVQLKMRRDGTRQWCRRLGIEEQRFYEVTKLRQQFQRILES-CGMVVASDSDSQ 698
            |.|||:.:||.                         |:.|.|....:..:|: |.....|.|..:
  Rat   551 DHFTLINIYNA-------------------------YQDTVLNSANEHCVETWCHNCFLSCSALR 590

  Fly   699 LTSAERATRHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEEQEEAQGDDMRDVDFRLRF 763
            :....||    ||  |:.:|   |.|.|                  ..|.|.|.....::.:
  Rat   591 MADVIRA----EL--LEIIK---RIELP------------------YAEPAFGSQENGLNIK--- 625

  Fly   764 DPRQLALLERSSRLDRHSVVVLLKLLLGSGFYPQLAISDEFNYCKGGGQQFFHTRLKPFVLQHPN 828
                                   |.|| ||::.|:|...:     |.|.....|. |.....||.
  Rat   626 -----------------------KALL-SGYFMQIARDVD-----GSGNYLMLTH-KQVAQLHPL 660

  Fly   829 SQFA--------KHFELLKLTESDLL-------PK------PDFYTPKLPLSKRHQLL 865
            |.:|        ..|....::|::.:       |:      |.:|...||.|:...:|
  Rat   661 SSYAITKKMPEWVLFHQFSISENNYIRVTSAVSPELFMQLVPQYYFSNLPPSESKDIL 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	61/177 (34%)
		DEXDc	163..298	CDD:238005	54/140 (39%)
		Helicase_C	358..490	CDD:278689	33/142 (23%)
		HA2	560..640	CDD:214852	19/80 (24%)
		OB_NTP_bind	<792..897	CDD:285018	21/95 (22%)
Dhx32	NP_001123511.1	HrpA	19..687	CDD:224557	180/740 (24%)
		DEXDc	86..202	CDD:238005	41/115 (36%)
		HA2	472..556	CDD:214852	19/83 (23%)
		OB_NTP_bind	597..704	CDD:285018	30/166 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900