DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32533 and dhx15

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_001108613.1	Gene:	dhx15 / 321931	ZFINID:	ZDB-GENE-030131-650	Length:	769	Species:	Danio rerio

Alignment Length:	647	Identity:	197/647 - (30%)
Similarity:	331/647 - (51%)	Gaps:	57/647 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 YLDFRQTEKFQRIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDF-- 186
            :.:...|.::..|.|.|   ..||:..:::...:.|:..:..::.|:||.||:||:||:..|.
Zfish    92 FTNLPHTPRYYEILKKR---LQLPVWEYKERFNDILNRHQSFVLVGETGSGKTTQIPQWCVDMVR 153

  Fly   187 ----GYRSIACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQ 247
                ..|.:|||||||:|.:|:.:|||.|:....|..|.:.||||...:..|.:.::|:|:|||:
Zfish   154 SLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLRE 218

  Fly   248 LAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGEEGA 312
            ......|::|..:||||.|||.|..|.|:||.|.::|.|..||:|:||||::...|..||  :..
Zfish   219 AMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQVYF--DNC 281

  Fly   313 RLVQVPGRLFPIKLRYLPPPALELKAGQATSKRSQRNRIDPAPFVQVLSLIDQQYPTSERGDVLI 377
            .|:.:|||..|:::.|.|.|              :|:.::.|    :.::|.......:.||||:
Zfish   282 PLLTIPGRTHPVEIFYTPEP--------------ERDYLEAA----IRTVIQIHMCEEDEGDVLL 328

  Fly   378 FVSGVNEIES----VVEAVHEYATEQTHWLVLPLHSGQAIADQSKVFD----YAPEGM--RKCIV 432
            |::|..||:.    :...:.:...:.....::||:|......|.::|:    ..|.|.  ||.:|
Zfish   329 FLTGQEEIDEACKRIKREIDDLGPDVGDIKIIPLYSTLPPQQQQRIFEPPPPRKPNGAIGRKVVV 393

  Fly   433 STNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRL 497
            ||||||||||:|||.||:|.|..|:..::...:.:.|....:||:||.||.||||||.||.||||
Zfish   394 STNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRL 458

  Fly   498 YTAEQYNA-FEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCAL 561
            ||.:.|.. .:....|||.|..|.:::||:..:|:.|:..|.|::.|..|.:.:.:..|....||
Zfish   459 YTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAAL 523

  Fly   562 SVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTDQRCVRER 626
            :.:..:|.||..:|..|::..:.||::....|....::|::.|||||  |......|:.:...:.
Zfish   524 NDDGDLTELGSMMAEFPLDPQLAKMVIASCDFNCSNEVLSITAMLSV--PQCFVRPTEAKKAADE 586

  Fly   627 ESLESDH--GDLFTLVRLYNVWVQLKMRRDGTRQWCRRLGIEEQRFYEVTKLRQQFQRILESCGM 689
            ..:...|  ||..||:.:|:.:.|    ...:.|||....|..:.......:|||..||::...:
Zfish   587 SKMRFAHIDGDHLTLLNVYHAFKQ----NHESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNL 647

  Fly   690 VVASDSDSQLTSAE------RATRHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEE 745
            ...|   ::.||.:      ||...|...|:..::|...:...:..::::.....|.:.:.|
Zfish   648 PRRS---TEFTSRDYYINIRRALVTGFFMQVAHLERTGHYLTVKDNQVVQLHPSTVLDHKPE 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	69/177 (39%)
		DEXDc	163..298	CDD:238005	59/140 (42%)
		Helicase_C	358..490	CDD:278689	49/141 (35%)
		HA2	560..640	CDD:214852	22/81 (27%)
		OB_NTP_bind	<792..897	CDD:285018
dhx15	NP_001108613.1	DEXDc	105..296	CDD:214692	73/195 (37%)
		DEXDc	128..269	CDD:238005	59/140 (42%)
		HELICc	356..449	CDD:197757	38/92 (41%)
		HA2	519..602	CDD:214852	22/84 (26%)
		OB_NTP_bind	636..739	CDD:285018	14/74 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810