DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32533 and kz

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster

Alignment Length:	972	Identity:	254/972 - (26%)
Similarity:	395/972 - (40%)	Gaps:	302/972 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IKKKADEHA------SSRRRTQINLIEFS----FLDHKAELVGLLQAKSRQVGRSLVE------- 51
            :.||.:..|      ||....::|.|:.|    .::.:.|    ||||.:......||
  Fly   131 LAKKKERQAQVLAEKSSASGLRVNAIKGSKRKLLVEEEEE----LQAKRKNPNVISVEEDDEDSS 191

  Fly    52 --NEADFWKFVGKYEAMMRS------TGQPVLPPRLA-EAELSSMQP-------YHRSKHLALRL 100
              :|.|       .||..:|      |...:.||::| :..:..::|       .|::
  Fly   192 SSDEDD-------EEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQT------- 242

  Fly   101 DADELLQEARDQMQSQFRHILLVYLDFRQTEKFQRIRKLRQTQRNLPIARFRKDLREALDTSRVV 165
                                  ||:...:|.:.|..| ||     |||....:.:.|.::.:.:|
  Fly   243 ----------------------VYVPVHRTTEVQNAR-LR-----LPILAEEQQVMETINENPIV 279

  Fly   166 IVAGDTGCGKSTQVPQYLYDFGY---RSIACTQPRRLACVSLCKRVAHEL-LDDYGSRVAFQIRF 226
            ||||:||.||:||:||:||:.||   :.|..|:|||:|.:::.||||||: |.:  |.|::.|||
  Fly   280 IVAGETGSGKTTQLPQFLYEAGYAQHKMIGVTEPRRVAAIAMSKRVAHEMNLPE--SEVSYLIRF 342

  Fly   227 ERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLL-----RAR 286
            |.:.|..|.|.|:|:|:||:::.....|.:|..:||||.|||:::.|.|:|:...::     |.:
  Fly   343 EGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQ 407

  Fly   287 PQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYLPPPALELKAGQAT-----SKRS 346
            | ||||:||||:.|..|     .|..||.::            |||.|:::|.|..     .||:
  Fly   408 P-LKLIIMSATLRVSDF-----TENTRLFKI------------PPPLLKVEARQFPVTIHFQKRT 454

  Fly   347 QRNRIDPAPFVQVLSLIDQQYPTSERGDVLIFVSGVNEIESVV---------------------- 389
            ..:.:..| :.:.|. |..:.|   .|.:||||:|..|:..:|
  Fly   455 PDDYVAEA-YRKTLK-IHNKLP---EGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGK 514

  Fly   390 --------------------------------------------------------------EA- 391
                                                                          ||
  Fly   515 VSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEAD 579

  Fly   392 VHEYATE----------------------------QTHWLVLPLHSGQAIADQSKVFDYAPEGMR 428
            :||...|                            |..| ||||:|..:...|:::|...|:|.|
  Fly   580 MHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLW-VLPLYSLLSSEKQNRIFLPVPDGCR 643

  Fly   429 KCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGV 493
            .|:||||:||||||:..:::|||.|:.|...:|...........:.||:|||||.|||||...|.
  Fly   644 LCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGH 708

  Fly   494 CFRLYTAEQYN-AFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETERI---EQTILA 554
            |:|||::..|| .||.:..|:|.:.|::.::|||..||:..|..|||...|:..::   |:.::.
  Fly   709 CYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIV 773

  Fly   555 LKQHCALSVEE--------KITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQN- 610
            |.   ||.|.:        .:|.||..::..||....||||.:......:...:.|.|.||||.
  Fly   774 LG---ALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEV 835

  Fly   611 -------------PLTNRAHTDQRCVRERESLESDH-----GDLFTLVRLYNVWVQLKMRRDGTR 657
                         |..||.|      |:|:|..:..     ||...|:|.... .:....:....
  Fly   836 LIETGVQRDEDVAPGANRFH------RKRQSWAASGNYQLLGDPMVLLRAVGA-AEYAGSQGRLP 893

  Fly   658 QWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVASDSDSQL---TSA--------------ERA 705
            ::|...|:.::...||.|||.|....:......|....|.:|   |.|              :|.
  Fly   894 EFCAANGLRQKAMSEVRKLRVQLTNEINLNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRV 958

  Fly   706 TRHGELRQLKAMKRRQR---------FEQP---RQRKLLKQSAGRVAEDEEEQEEAQGDDMR 755
            .|...|..:...:.|:|         .|:|   ....:|:|.|......:|..|...||..:
  Fly   959 ARKVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTK 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	72/180 (40%)
		DEXDc	163..298	CDD:238005	65/143 (45%)
		Helicase_C	358..490	CDD:278689	57/244 (23%)
		HA2	560..640	CDD:214852	27/106 (25%)
		OB_NTP_bind	<792..897	CDD:285018
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	229/855 (27%)
		DEXDc	279..418	CDD:238005	65/141 (46%)
		P-loop_NTPase	369..>500	CDD:304359	47/153 (31%)
		HELICc	619..704	CDD:197757	38/84 (45%)
		HA2	774..859	CDD:214852	24/93 (26%)
		OB_NTP_bind	915..1039	CDD:285018	20/106 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468056
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930