DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32533 and Dhx36

DIOPT Version :10

Sequence 1:NP_728244.1 Gene:CG32533 / 32933 FlyBaseID:FBgn0052533 Length:1139 Species:Drosophila melanogaster
Sequence 2:NP_001101148.1 Gene:Dhx36 / 310461 RGDID:1308767 Length:1000 Species:Rattus norvegicus


Alignment Length:1084 Identity:292/1084 - (26%)
Similarity:456/1084 - (42%) Gaps:266/1084 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KKKADEHASSRRRTQINLIEFSFLDHKAELVGLLQAKSRQVGRSLVENEADFWKFVGK---YEAM 66
            :::|..|...||..||           .:|:..:|||:.:      ::||....|..:   |...
  Rat    72 QERAVVHMDERREEQI-----------VQLLNSVQAKNDK------DSEAQISWFAPEDHGYGTE 119

  Fly    67 MRSTGQPVLPPRLAEAELSSM----QPYHRSKHLALRLDADELLQE-----ARDQMQSQFRHILL 122
            :.|..:.....:|...|...:    :.|..:....:..|::.|||:     ..||.       ||
  Rat   120 VSSEKKINSEKKLDNQEKKLLNQEKKTYRITDKSYIDRDSEYLLQQNEPNLGLDQQ-------LL 177

  Fly   123 VYLDFRQTE----KFQRIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYL 183
            ..|..::|:    :.||.||      .||....:|:|...::..:|.:::|:|||||:|||.|::
  Rat   178 EDLQKKKTDPRYIEMQRFRK------KLPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFI 236

  Fly   184 YD----FGYRS---IACTQPRRLACVSLCKRVAHELLDD--YGSRVAFQIRFE-RSRTKLTNILF 238
            .|    .|..|   |.||||||::.:|:.:|||.|..:.  .|:...:|||.: |...|..:||:
  Rat   237 LDNYIERGIGSACRIVCTQPRRISAISVAERVAAERAESCGNGNSTGYQIRLQSRLPRKQGSILY 301

  Fly   239 ITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELF 303
            .|.|::|:.|...:.|.....::|||||||||..|.|:.|.|.||..|..||:||||||:|.|.|
  Rat   302 CTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKF 366

  Fly   304 HGYFGEEGARLVQVPGRLFPI----------KLRYLPPPALELKAGQATSKR----SQRNRID-- 352
            ..|||  ...::.:||..||:          |:||.|    |.|..::..||    ...||.:  
  Rat   367 SEYFG--NCPMIHIPGFTFPVVEYLLEDIIEKIRYFP----EQKEHRSQFKRGFMQGHVNRQEKE 425

  Fly   353 ---------------------PAPFVQVLSLIDQ------------QYPT--SERGDVLIFVSGV 382
                                 .|..:.||.::|.            :|..  .|.|.:|:|:.|.
  Rat   426 EKEAIYKERWPAYIKELQTRYSASTIDVLEMMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGW 490

  Fly   383 NEIESVVEAVHEYATEQT-----HWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLT 442
            :.|.:    :|:....|.     .:|::||||.....:|::||...|.|:||.:::|||||||:|
  Rat   491 DNIST----LHDLLMSQVMFKSDRFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSIT 551

  Fly   443 VDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFE 507
            :|.|.:|:|.||:||.:||.......:...||||::|.||||||||..||.|:.||...:.:..:
  Rat   552 IDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLD 616

  Fly   508 AYPTPEIYRVPLDTMLLQMVSMGLPDVRAF--PFIEAPETERIEQTILALKQHCALSVEEKITPL 570
            .|..|||.|.||:.:.||:..:.|..:..|  ..::.|..|.:..:|..|.:..||..:|::|||
  Rat   617 DYQLPEILRTPLEELCLQIKILRLGGIAYFLSRLMDPPSDEAVVLSIKHLMELSALDKQEELTPL 681

  Fly   571 GRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQN----PLTNRAHTDQRCVRERESLES 631
            |..||.||||..||||:|.|::|..::.:||:||.||.::    ||......|.|.....:...|
  Rat   682 GVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKELAKETRS 746

  Fly   632 DHGDLFTLVRLYNVWVQLKMRRDGTR---QWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVAS 693
            ||   .|:|..:..|.:.|.|  |.|   .:|....:.......:..::.||...|...|.|.: 
  Rat   747 DH---LTVVNAFEGWEEAKRR--GFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSS- 805

  Fly   694 DSDSQLTSAERATRHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEEQEEAQGDDMRDVD 758
                                          ..|:..|      ..:..|.|:             
  Rat   806 ------------------------------RSPKDPK------ANINSDNEK------------- 821

  Fly   759 FRLRFDPRQLALLERSSRLDRHSVVVLLKLLLGSGFYPQLAISDEFNYCKGGGQQFFHTRLKPFV 823
                                      ::|.::.:|.||::| ....|..|.......||:....|
  Rat   822 --------------------------IIKAVICAGLYPKVA-KIRLNLGKKRKMVKVHTKSDGLV 859

  Fly   824 LQHPNSQFAKHFELLKLTESDLLPKPDFYTPKLPLSKRHQLLCYQSLLETAKPYLINCIRLPAAQ 888
            ..||.|        :.:.::|.               .:..|.|...:.|:..||.:|..: :..
  Rat   860 SIHPKS--------VNVEQTDF---------------HYNWLIYHLKMRTSSIYLYDCTEV-SPY 900

  Fly   889 TLLLFSFAIDTNAGITQ--IACDGWLGLDLPMPGSGMELLRRAIE-LRRRWSRLLYDKLD----- 945
            .||.|...|.......|  ||.|.|:....|      |.:...:: ||:....||.:|::     
  Rat   901 CLLFFGGDISIQKDKDQEIIAVDEWIVFQSP------ERIAHLVKGLRKELDILLQEKIECPHPV 959

  Fly   946 ---DLKSKQESPSHSSDDRSSALWQDLVDYMALDVAYAIRRLLP 986
               |.||           |..|:...::|.:... ..||.|.||
  Rat   960 DWNDTKS-----------RDCAVLSAILDLIKTQ-EKAIPRNLP 991

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32533NP_728244.1 HrpA 145..>619 CDD:441249 191/545 (35%)
OB_NTP_bind 792..897 CDD:400182 22/104 (21%)
Dhx36NP_001101148.1 Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250|UniProtKB:Q9H2U1 1..192 28/143 (20%)
Required for the pre-miR-134 transport. /evidence=ECO:0000269|PubMed:23651854 1..96 7/34 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..53
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250|UniProtKB:Q9H2U1 1..43
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H2U1 45..97 8/35 (23%)
DSM (DHX36-specific motif). /evidence=ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q9H2U1 45..67
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 98..378 95/300 (32%)
DEXHc_DHX36 199..378 CDD:350739 73/180 (41%)
HrpA 207..>768 CDD:441249 199/575 (35%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 257..309 17/51 (33%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 326..329 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 379..620 76/248 (31%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 490..549 20/62 (32%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9H2U1 509..520 5/10 (50%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 621..690 24/68 (35%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 630..689 17/58 (29%)
OB_NTP_bind 823..909 CDD:400182 23/110 (21%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 833..897 17/87 (20%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 841..852 2/10 (20%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 862..892 8/52 (15%)
Blue background indicates that the domain is not in the aligned region.

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