DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32533 and Ythdc2

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	XP_038953178.1	Gene:	Ythdc2 / 307446	RGDID:	1563192	Length:	1434	Species:	Rattus norvegicus

Alignment Length:	1388	Identity:	323/1388 - (23%)
Similarity:	498/1388 - (35%)	Gaps:	488/1388 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EFSFLDHKAELVGLLQAKSRQVGRSLVENEADFWKFVGKYEAMMRSTGQPVLPPRLAEAELSSMQ 88
            |.:|:...::.:||: :||:..|             ..:|..:.:..|.     ..|.| :.:..
  Rat    78 ERAFIHRLSQSLGLV-SKSKGKG-------------ANRYLTVKKKDGS-----ETAHA-MMTCN 122

  Fly    89 PYHRSKHLALRL---------DADELLQEARDQMQSQFRHILLVYLDFRQTEK------------ 132
            ..|.:||....|         :..|||.      :::..::..|..:.|:..|
  Rat   123 LTHNTKHAVRSLIQRFPVTNKERTELLP------KTERGNVFAVEAENREMSKTSGRLNNGIPQV 181

  Fly   133 --------FQRIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYR 189
                    |...|      ::||:...::::.:.:..::||::.|:||.||:||:||:|.|..::
  Rat   182 PVKRGESEFDSFR------QSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFK 240

  Fly   190 S-----IACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQL- 248
            :     |.||||||||.:::.:|||.|..:..|..:.:|||.|...:..|.:.|.|.|:|||.|
  Rat   241 NGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLM 305

  Fly   249 AVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGEEGAR 313
            |..:.|.....:|:||:|||:.|.||||...:.||:..|.|||||.||.::|.||..|||  ...
  Rat   306 AGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFG--SCP 368

  Fly   314 LVQVPGRLFPIK------------------LRYLPPPALELK----------AGQATSK-RSQRN 349
            ::.:.||.|.:|                  |:|......|.|          |.:.|.| .|||.
  Rat   369 VIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQ 433

  Fly   350 RI-------------------------------------------------DPAPFVQVLSLI-- 363
            |.                                                 |...|.||..||
  Rat   434 RAVASVSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILT 498

  Fly   364 --------------------------------------------------------------D-- 364
                                                                          |
  Rat   499 ENVSVDYRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLL 563

  Fly   365 QQYPTS-------------------------------------------------------ERGD 374
            :.|..|                                                       :.|.
  Rat   564 ESYSASLEFGNLDESSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGA 628

  Fly   375 VLIFVSGVNEIESVVEAV----HEYATEQTHWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTN 435
            :|||:.|.:||..:.:.:    ..:|.....:.|..|||....:||.||....|.|:||.|:|||
  Rat   629 ILIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTN 693

  Fly   436 IAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTA 500
            |||||:||:.|.||:|||||||.:|||......||..|:||:||.||||||||..||:||||::.
  Rat   694 IAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSR 758

  Fly   501 EQYNAFEAYPTPEIYRVPLD-----TMLLQMVSMGLPDVRAFPFIEAPETER---IEQTILALKQ 557
            .::.....:.|||:.|:||.     |.||..|:..:.|.    .::|||...   :...:..||.
  Rat   759 LRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCTIADF----LMKAPEPPPALIVRNAVQMLKT 819

  Fly   558 HCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTDQR- 621
            ..|:...|.:|.||..||:||||..:|||:|...|...::.:||:|..|:.::|........|:
  Rat   820 IDAMDAWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKR 884

  Fly   622 ----CVRER--ESLESDHGDLFTLVRLYNVWVQLKMRRDGTRQWCRRLGIEEQRFYEVTKLRQQF 680
                | |:|  ....|||   ..|:|.:..|  .|.|.||   |       |:.|.|...|.|..
  Rat   885 AAMLC-RKRFTAGTFSDH---MALLRAFQAW--QKARSDG---W-------ERAFCEKNFLSQAT 933

  Fly   681 QRILESCGMVVASDSDSQLTSAERATRHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEE 745
            ..|:  .||              |....|:||....::.|
  Rat   934 MEII--IGM--------------RTQLLGQLRASGFVRAR------------------------- 957

  Fly   746 QEEAQGDDMRDVDFRLRFDPRQLALLERSSRLDRHSVVVLLKLLLGSGFYPQLAISDEFNYCKGG 810
                .|.|:|||                ::..:..:||   |..|.:|.||.|...|..|....|
  Rat   958 ----GGGDIRDV----------------NTNSENWAVV---KAALVAGMYPNLVHVDRENVVLTG 999

  Fly   811 GQQFFHTRLKPFVLQHPNSQFAKHFELLKLTESDLLPKPDFYTPKLPLSKRH---------QLLC 866
            .::       ..|..||.|               :|.:|.:  .|:|.:...         ..|.
  Rat  1000 PKE-------KKVRFHPTS---------------VLSQPQY--KKIPPANGQAAAIQALPTDWLI 1040

  Fly   867 YQSLLETAKPYLINCIRLPAAQTLLLF---------------SFAID--------------TNAG 902
            |..:....:...|.|.......|:|:|               ||..|              |.|.
  Rat  1041 YDEMTRAHRIANIRCCSAVTPVTVLVFCGPARLTSNALQEPSSFRADGIPNDSSDSEMEDRTTAN 1105

  Fly   903 ITQIACDGWLGLDLPMPGSGMELLRRAIELRRRWSRLL----------YDKLDDLKSKQESPSHS 957
            :..:..|.||...|....:.:     .::||::|..|.          :.::|:...:......|
  Rat  1106 LAALKLDEWLNFKLEPEAASL-----LLQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLS 1165

  Fly   958 SDDRSSALWQDLVDYMALDVAYAIRRLLPADIKRLYTHQAPSARLAELKENPFAVDFPMTPNEEK 1022
            ::::|:.|.|                  |:.|     .|.|....:|  |.|.|..: .:.|..|
  Rat  1166 TEEQSAGLQQ------------------PSGI-----GQRPRPMSSE--ELPLASSW-RSNNSRK 1204

  Fly  1023 GGLNVSEHVVYSCLAEQQWTTAMDATLRAEPWQCTRCDFELEEFDVLEQLVHRSKCKRRKAQESR 1087
            .    |....:|     ..:||.:..|...|........:.::..:|    |..:....::.:|
  Rat  1205 S----SADTEFS-----DGSTAAERVLMKSPSPALHPPQKYKDRGIL----HPKRSTDDRSDQS- 1255

  Fly  1088 TAKTTSTESSTEVASSSSSHSSG 1110
            :.|:|.:.|.....:|.|..|||
  Rat  1256 SVKSTDSSSYPSPCASPSPPSSG 1278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	72/195 (37%)
		DEXDc	163..298	CDD:238005	62/140 (44%)
		Helicase_C	358..490	CDD:278689	66/256 (26%)
		HA2	560..640	CDD:214852	28/86 (33%)
		OB_NTP_bind	<792..897	CDD:285018	24/128 (19%)
Ythdc2	XP_038953178.1	R3H_DEXH_helicase	50..108	CDD:100077	8/43 (19%)
		HrpA	193..>1020	CDD:224557	247/942 (26%)
		DEXHc_YTHDC2	197..372	CDD:350745	70/176 (40%)
		ANK repeat	509..541	CDD:293786	0/31 (0%)
		ANK repeat	543..571	CDD:293786	3/27 (11%)
		OB_NTP_bind	975..1070	CDD:400182	25/121 (21%)
		YTH	1293..1422	CDD:410979
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920