DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32533 and Tdrd9

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	XP_017450003.1	Gene:	Tdrd9 / 299343	RGDID:	1306942	Length:	1396	Species:	Rattus norvegicus

Alignment Length:	1242	Identity:	306/1242 - (24%)
Similarity:	496/1242 - (39%)	Gaps:	296/1242 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RSLVENEADFWKFVGKYEAMMRSTGQPVLPPRL-AEAELSSMQPYHRSKHLALRLDADELLQEAR 110
            |.|..::.:.|..:||....:...|   |||.. |||....:|   ||:    .:.::....:|:
  Rat     3 RKLTVDQINDWFTIGKTVTNVELLG---LPPAFPAEAPREEVQ---RSE----EVPSEAPTAQAQ 57

  Fly   111 DQMQ--------SQFRHIL------LVYLD-FRQTE-----------------------KFQRIR 137
            |.::        |.|...|      :.|:: :||.|                       |...:.
  Rat    58 DPVKATALARPASAFGRSLSQRSSEVEYINKYRQLEAQELDIYGQDQPPSGPGLRSPLAKISNVA 122

  Fly   138 KLRQT---QRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD-FGYRSIAC----T 194
            .:.:|   ..:|||.|.::::...::::.|||:.|.||.|||||:|||:.| :..||..|    |
  Rat   123 CIPETTYKYPDLPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQRSAFCNIVVT 187

  Fly   195 QPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDA 259
            |||::...|:.:.::.|.....|..|.:|:..|::.|:.|.::::|.|:||:::..|.:|.::..
  Rat   188 QPRKIGASSIARWISKERSWTLGGLVGYQVGLEKTATEDTRLIYMTTGVLLQKIVSAKSLMEFTH 252

  Fly   260 LILDEIHERNLFGDFLLGVTKCLLRARPQ-LKLILMSATINVELFHGYFG------EEGARLVQV 317
            :.:||:|||....||||.|.:.|||...: :|:||||||||.:.|..||.      ...|.:.:|
  Rat   253 VFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVILMSATINCKQFADYFAVPVQNKMNPAYVFEV 317

  Fly   318 PGRLFPIKLRY-----------LPPPALELKA----------------GQATSKRSQRNRIDPAP 355
            .|:...|:..|           |||..||...                .....|.|.......|.
  Rat   318 EGKPHTIEQYYLNDLGHIYHSGLPPYRLEEPVITKDVYEVAVSLIQMFDDLDMKESGNKTWSGAQ 382

  Fly   356 FVQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHEYATEQTH--WLVLPLHSGQAIADQSK 418
            ||            |||..||:|:.|:.||    ..:||..|...|  ..|.||||...:.:|:.
  Rat   383 FV------------SERSSVLVFLPGLGEI----NYMHELLTNMIHKRLQVYPLHSSVTLEEQNN 431

  Fly   419 VFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRK 483
            ||.....|.||.|:||||||:|:||..|::|:|....:.:..|.....|.|:..|.||:|.||||
  Rat   432 VFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRK 496

  Fly   484 GRAGRTGPGVCFRLYTAEQY-NAFEAYPTPEIYRVPLDTMLL--QMVSMGLPDVRAFPFIEAPET 545
            |||||...|.|:||...:.: :|...:..||:.|.||.:.:|  :::.||.|.......:..|..
  Rat   497 GRAGRVSKGYCYRLIHRDFWDSAIPDHVVPEMLRCPLGSTVLKVKLLDMGEPRALLATALSPPSL 561

  Fly   546 ERIEQTILALKQHCALSV----------EEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLL 600
            ..||:|||.||:..||:|          :.::|.|||.||.|||...:||::::|.||..:::.|
  Rat   562 SDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVSQQLGKLIVLGHVFGCLDECL 626

  Fly   601 TLAAMLSVQNPLTN--RAHTDQRCVRERESLE-SDHGDLFTLVRLYNVWVQLKMRRD-----GTR 657
            .:||.||::|..|.  |.|.|.  .|.:.... |...|...||..:..|...:.|.:     ...
  Rat   627 IIAAALSLKNFFTMPFRQHLDG--YRNKVHFSGSSRSDCLALVEAFRAWQACRQRGELRHPKDEL 689

  Fly   658 QWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVASDSDSQLTSAERATRHGELRQLKAMKRR-- 720
            .|.|...|:.:|..||.:|.::.:..:....|.|             ..||..|.|....|:|
  Rat   690 DWGRLNYIQIKRIREVAELYEELKNRISQFNMFV-------------DPRHPVLDQEYPYKQRFI 741

  Fly   721 -------------QRFEQPRQRKLLKQSAGRVAEDEEEQEEAQGDDMRDVDFRLRFDPRQLALLE 772
                         ..|.||.:...:::.|||                         ||:
  Rat   742 LQVVLAGAFYPNYFTFGQPDEEMAVRELAGR-------------------------DPK------ 775

  Fly   773 RSSRLDRHSVVVLLKLLLGSGFYPQLAISDEFNYCKGGGQQFFHTRLKPFV--LQHPNSQF---- 831
                     ..|:||.:...||.....:...|..| |..:.......|.||  .::|..:|
  Rat   776 ---------TTVVLKHIPPYGFLYYKQLQSLFRQC-GQVKSIVFDGAKAFVEFSRNPTERFKTLP 830

  Fly   832 ----AKHFELLKLTESDLLPKPDFYTPKL---PLSK-RHQLLCYQSLLETAKPYLINCIRLPAAQ 888
                |.....||::....:...:....|:   .:|| |:..:......:|..|..::...|...:
  Rat   831 AVNLAVKMSQLKVSLELSIHAAEEIEGKVQGGSVSKLRNTRVNVDFQKQTVDPMQVSFNTLDRPR 895

  Fly   889 TLLLFSFAIDTNAGITQIA-CDGWLGLDLPMPGSGMELLRRAIELRRRWSRLLYDKLDDLKSKQE 952
            |:......:|    :|::| |             ...||.:.:|:...|...:.::..:|..:..
  Rat   896 TVADLLLTVD----VTEVALC-------------AHTLLLQVVEVGHFWGYRIDERNAELLRQLT 943

  Fly   953 S----------PSHSSDD----------------RSSALWQDLVDYMALDVAYAIRRLLPADIKR 991
            :          |.|...|                |:..|:..........|.|..|..:..|:.|
  Rat   944 AEINRLELVPLPIHPHPDLVCLAPFTDYNKESYFRAQILYVSGNSAEVFFVDYGNRSHVDLDLLR 1008

  Fly   992 LYTHQAPSARLAELKENPF-AVDF---PMTPNEEKGGLNVSEHVVYSCLAEQQWTTAMDATLRAE 1052
                :.|    .:|.|.|| |::|   .|.|:.:            |.:..:.|:...:....|
  Rat  1009 ----EIP----CQLLELPFQALEFKICKMRPSAK------------SLICGEHWSGGANGRFAA- 1052

  Fly  1053 PWQCTRCDFELEEFDVLEQLVHRSKCKRRKAQES--------RTAKTTSTESSTEVASSSSSHSS 1109
              ..:.|...::.|.::..::|....:...||::        |.......|.|.|  |..|....
  Rat  1053 --LVSGCPLLVKVFSIVHSVLHVDVYRYSGAQDAVNIRDVLIREGYAELAEESYE--SKQSYEVL 1113

  Fly  1110 GGYYCNS 1116
            .|::..|
  Rat  1114 KGFFAKS 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	65/183 (36%)
		DEXDc	163..298	CDD:238005	55/140 (39%)
		Helicase_C	358..490	CDD:278689	53/133 (40%)
		HA2	560..640	CDD:214852	30/92 (33%)
		OB_NTP_bind	<792..897	CDD:285018	21/118 (18%)
Tdrd9	XP_017450003.1	DEXDc	146..327	CDD:214692	65/180 (36%)
		DEXDc	151..292	CDD:238005	55/140 (39%)
		Helicase_C	385..502	CDD:278689	52/120 (43%)
		HA2	590..667	CDD:214852	27/78 (35%)
		TUDOR	924..1026	CDD:278965	19/109 (17%)
		TUDOR	962..1009	CDD:119391	7/50 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920