DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32533 and Dhx16

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_997661.1	Gene:	Dhx16 / 294232	RGDID:	1302963	Length:	1044	Species:	Rattus norvegicus

Alignment Length:	800	Identity:	253/800 - (31%)
Similarity:	400/800 - (50%)	Gaps:	121/800 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KKKADEHASSRRRTQINLIEFSFLDHKAELVGLLQAKSRQVGRSL-----VENEADFWKFVG--- 61
            ||...|:.:.|.|.::..:|....|.:. |.|.::. ||...|.|     |.:.|..::..|
  Rat   230 KKSRREYLAKREREKLEDLEAELADEEV-LFGDVEL-SRHERRELKYKRRVRDLAREYRAAGEQE 292

  Fly    62 KYEAMMR------STGQPVLPPRLAEAELSSMQPYHRSKHLALRLDADELLQEARDQMQSQFRHI 120
            |.||..|      :.|||.....:.|.|..:.....|....| ||||..|...|||....:.::.
  Rat   293 KLEATNRYHMPKETRGQPARATDIVEEESGAPGEEQRRWEEA-RLDAASLKFGARDAAAQEPQYQ 356

  Fly   121 LLVYLDFRQTEKFQRIRKLR-------------QTQ---------RNLPIARFRKDLREALDTSR 163
            |::..|  :|.:|.|..:|:             |.|         |:||:..||::|..|:...:
  Rat   357 LVLEED--ETIEFVRAAQLQGDEEPSSGPPLSAQAQQKESIQAVRRSLPVFPFREELLTAIANHQ 419

  Fly   164 VVIVAGDTGCGKSTQVPQYLYDFGY----RSIACTQPRRLACVSLCKRVAHELLDDYGSRVAFQI 224
            |:|:.|:||.||:||:||||::.||    ..||||||||:|.:|:..|||.|:....|:.|.:.|
  Rat   420 VLIIEGETGSGKTTQIPQYLFEEGYTKKGMKIACTQPRRVAAMSVAARVAREMGVKLGNEVGYSI 484

  Fly   225 RFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQL 289
            |||...::.|.:.::|:|:|||:.....:|..|..:::||.|||.|..|.|.|:.|.:.|.||:|
  Rat   485 RFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPEL 549

  Fly   290 KLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYLPPPALELKAGQATSKRSQRNRIDPA 354
            |:::.|||::...|..:|  :.|.:.::|||.||:.:.|...|                    .|
  Rat   550 KVLVASATLDTARFSAFF--DDAPVFRIPGRRFPVDIFYTKAP--------------------EA 592

  Fly   355 PFVQ--VLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHE----YATEQTHWLVLPLHSGQAI 413
            .:::  |:|:: |.:.|...||:|:|::|..|||:..|.:.:    ..::....||||:::....
  Rat   593 DYLEACVVSVL-QIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPS 656

  Fly   414 ADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSS 478
            ..|:::|...|.|.||.:|:|||||||||::|:.:|:|.|..|:.:::.....:.|.....||:|
  Rat   657 DMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKAS 721

  Fly   479 ADQRKGRAGRTGPGVCFRLYTAEQY-NAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEA 542
            |:||.|||||...|.|||||||..| :..|....|||.|..|..::|.:.|:|:.|:..|.|::.
  Rat   722 ANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDP 786

  Fly   543 PETERIEQTILALKQHCALSVEE---KITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAA 604
            |..|.:   :|||:|..||....   ::|..||.:|.|||:..:.||:|....:...|::||:||
  Rat   787 PPYETL---LLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAA 848

  Fly   605 MLSVQNPLTNR-----AHTDQRCVRERESLESDHGDLFTLVRLYNVWVQLKMRRDG-TRQWCRRL 663
            ||||.|.:..|     .|.|    ..|.:.....||...|:.:|..|.:     .| :.|||...
  Rat   849 MLSVNNSIFYRPKDKVVHAD----NARVNFFLPGGDHLVLLNVYTQWAE-----SGYSSQWCYEN 904

  Fly   664 GIEEQRFYEVTKLRQQFQRILESCGMVVAS-DSD-----SQLTS-----AERATRHGELRQLKAM 717
            .::.:.......:|:|.:.:||...:.:.| ..|     ..:||     ..|.||.|    .:.:
  Rat   905 FVQFRSMRRARDVREQLEGLLERVEVGLTSCQGDYVRVRKAITSGYFYHTARLTRSG----YRTV 965

  Fly   718 KRRQR---------FE-QPR 727
            |::|.         || |||
  Rat   966 KQQQTVFIHPNSSLFEQQPR 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	71/175 (41%)
		DEXDc	163..298	CDD:238005	60/138 (43%)
		Helicase_C	358..490	CDD:278689	50/137 (36%)
		HA2	560..640	CDD:214852	28/87 (32%)
		OB_NTP_bind	<792..897	CDD:285018
Dhx16	NP_997661.1	DEXDc	402..584	CDD:214692	75/183 (41%)
		DEXDc	419..558	CDD:238005	60/138 (43%)
		HELICc	583..740	CDD:238034	56/177 (32%)
		HA2	801..885	CDD:214852	28/87 (32%)
		OB_NTP_bind	920..1018	CDD:285018	17/69 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810