DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32533 and Dhx8

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	XP_006247348.1	Gene:	Dhx8 / 287727	RGDID:	1310723	Length:	1242	Species:	Rattus norvegicus

Alignment Length:	871	Identity:	258/871 - (29%)
Similarity:	408/871 - (46%)	Gaps:	155/871 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DEHASSRRRTQI--------------NLI---EFSFLDHKAELVGLL----QAKSRQVGRSLVEN 52
            |:....:|.|:|              |::   ||...|   |..|:|    ..:...:...|||.
  Rat   405 DDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD---EETGILPKVDDEEDEDLEIELVEE 466

  Fly    53 EADFWKFVGKYE-------------------AMMRST---GQPVLPPRLAEAELSSMQPYHRSKH 95
            |..|.:...|..                   |||:|.   .:..|.....|||:.|: |...:||
  Rat   467 EPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSI-PMGLNKH 530

  Fly    96 LALRLDADELLQEARDQMQSQFRHILLVYLDFRQTEKF-----------QRIRKLRQTQRNLPIA 149
            .     .|.|......|:.:..|.|.::..|..:.:|.           :....:.:.:.:|||.
  Rat   531 W-----VDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIY 590

  Fly   150 RFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS---IACTQPRRLACVSLCKRVAHE 211
            :.::.|.:|:..::::||.|:||.||:||:.|||.:.||.|   |.||||||:|.:|:.|||:.|
  Rat   591 KLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEE 655

  Fly   212 LLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLL 276
            .....|..|.:.||||...:..|.|.::|:|:|||:..:..:|.||..::|||.|||.:..|.|.
  Rat   656 FGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLF 720

  Fly   277 GVTKCLLRARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYLPPPALELKAGQA 341
            |:.|..::.|..:|||:.|||::...|..||.|  |.:..:|||.:|:::.|
  Rat   721 GLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYE--APIFTIPGRTYPVEILY------------- 770

  Fly   342 TSKRSQRNRIDPAPFVQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHE----YATEQTHW 402
             :|..:.:.:| |..:.|:    |.:.|...||:|:|::|..||::..|.::|    ...:....
  Rat   771 -TKEPETDYLD-ASLITVM----QIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPEL 829

  Fly   403 LVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQ 467
            ::||::|......|:::||.||.|.||.:::|||||||||:||:.:|||.|.||:..:::.....
  Rat   830 IILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGID 894

  Fly   468 RLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPT--PEIYRVPLDTMLLQMVSMG 530
            :|....:|::.|.||.|||||||||.|:||||...|.. |...|  |||.|..|.:.:|.:.:||
  Rat   895 QLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRD-EMLTTNVPEIQRTNLASTVLSLKAMG 958

  Fly   531 LPDVRAFPFIEAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPE 595
            :.|:.:|.|::||..|.:...:..|....||..|..:|.|||.:|..|:|..:.|||:|......
  Rat   959 INDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGC 1023

  Fly   596 VEQLLTLAAMLSVQN----PLTNRAHTDQRCVRERESLESDHGDLFTLVRLYNVWVQLKMRRDGT 656
            .|::||:.:||||||    |...:|..||:    :.......||..||:.:||.|...|.    :
  Rat  1024 SEEMLTIVSMLSVQNVFYRPKDKQALADQK----KAKFHQTEGDHLTLLAVYNSWKNNKF----S 1080

  Fly   657 RQWCRRLGIEEQRFYEVTKLRQQFQRILE-------SCGMVVASDSDSQLTSAERATRHGELRQL 714
            ..||....|:.:.......:|:|...|::       |||        ......::|...|..|
  Rat  1081 NPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCG--------KSTVRVQKAICSGFFR-- 1135

  Fly   715 KAMKRRQRFEQPRQ--RKLLKQSA--------------------GRVAEDEEEQEEAQGDDMR-D 756
            .|.|:     .|::  |.|:.|..                    ..|...:|...|....|.| .
  Rat  1136 NAAKK-----DPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWL 1195

  Fly   757 VDFRLRF----DPRQLALLERSSRLD 778
            |:|...|    ||.:|:..::..||:
  Rat  1196 VEFAPAFFKVSDPTKLSKQKKQQRLE 1221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	72/174 (41%)
		DEXDc	163..298	CDD:238005	60/137 (44%)
		Helicase_C	358..490	CDD:278689	50/135 (37%)
		HA2	560..640	CDD:214852	30/83 (36%)
		OB_NTP_bind	<792..897	CDD:285018
Dhx8	XP_006247348.1	S1_DHX8_helicase	287..365	CDD:240189
		DEXDc	583..768	CDD:214692	75/186 (40%)
		DEXDc	604..742	CDD:238005	60/137 (44%)
		HELICc	767..924	CDD:238034	59/175 (34%)
		HA2	986..1068	CDD:214852	30/85 (35%)
		OB_NTP_bind	1102..1201	CDD:285018	21/113 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810