DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32533 and Dhx40

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_001005873.1	Gene:	Dhx40 / 287595	RGDID:	1359618	Length:	779	Species:	Rattus norvegicus

Alignment Length:	752	Identity:	208/752 - (27%)
Similarity:	344/752 - (45%)	Gaps:	140/752 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 TQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS---IACTQPRRLACVS 203
            |....||.:.||.|.:|:..:..:||.|:||.||:||:|:|||:.|:..   |..||||::|.:|
  Rat    49 TTPTFPIQKQRKKLIQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIGVTQPRKVAAIS 113

  Fly   204 LCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHER 268
            :.:|||.|:....||:|.:|:||:...:|.|.|.::|:|.||:.:....||:::..:||||.|||
  Rat   114 VAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLNKFSVIILDEAHER 178

  Fly   269 NLFGDFLLGVTKCLLR-----ARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRY 328
            .|..|.|.|:.|.|.:     .:..||:::||||:.:.....:||  ...:..:||||:|::.::
  Rat   179 TLTTDILFGLLKKLFQDKSPNRKEHLKVVVMSATMELAKLSAFFG--NCPIFDIPGRLYPVREKF 241

  Fly   329 LPPPALELKAGQATSKRSQRNRIDPAPFVQVLSLIDQQYPTSE-RGDVLIFVSGVNEIESVVEAV 392
            .          .....|.:.|    ..::|.:..:......:| .||:|:|::|..|||...|.:
  Rat   242 C----------NLIGPRDREN----TAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELL 292

  Fly   393 --------HEYATEQT---HWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGV 446
                    ::|..:.|   ..|:||.:.......|.::|...|.|:|||::||||:.||||:||:
  Rat   293 FQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGI 357

  Fly   447 RFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYN-AFEAYP 510
            |:|||.|.||::|.:.......|:...:|||.|.||.||||||..|.|||:|:.:.:| ....:.
  Rat   358 RYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTASGKCFRIYSKDFWNQCMPDHV 422

  Fly   511 TPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCALSVEEKITPLGRSLA 575
            .|||.|..|.:::|.:..:.:.||..||:::.|....|.:.:..|.|..|:.....:|.||.|:.
  Rat   423 IPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMV 487

  Fly   576 NLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTDQRCVRERESLE-----SDHGD 635
            ..|:...:...::..:.....:.||.:||||||:|........:.:...|::..|     ....|
  Rat   488 EFPLPPHLTCAVIRAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQKHRELAAKAGGFND 552

  Fly   636 LFTLVRLYNVWVQLKMRRDGT-RQWCRR-----------LGIEEQRFYEVTKLRQQ--FQR---- 682
            ..||..::.     :.:..|. ..||::           ..:|.|....:.||:||  |.|
  Rat   553 FATLAVIFE-----QCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPRETFE 612

  Fly   683 -----ILESC------------------------GMVV----ASDSDSQLTSAERATRHGEL--- 711
                 :|..|                        |..|    :|....|.|..|....|..|
  Rat   613 GPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTT 677

  Fly   712 ---------------------------RQLKAMKRRQRFEQPRQ----RKLLKQSAGRVAEDEEE 745
                                       ..|.::.||:..:..|:    ::.:||....::::..:
  Rat   678 KVYARIVCPIRYEWVRDLLPKLHELNAHDLSSVARREMRDDARRKWTNKENVKQLKDGISKEVLK 742

  Fly   746 QEEAQGDDMRDVDFRLRFDPRQLALLER-SSRLDRHS 781
            :.:.:.||....|.|.||       ||| ..|:..||
  Rat   743 KMQRRNDDKSISDARARF-------LERKQQRIQDHS 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	68/179 (38%)
		DEXDc	163..298	CDD:238005	58/142 (41%)
		Helicase_C	358..490	CDD:278689	53/143 (37%)
		HA2	560..640	CDD:214852	19/84 (23%)
		OB_NTP_bind	<792..897	CDD:285018
Dhx40	NP_001005873.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		1/3 (33%)
		HrpA	51..750	CDD:224557	195/719 (27%)
		DEAH box	173..176		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810