DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32533 and DHX30

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	XP_011531792.1	Gene:	DHX30 / 22907	HGNCID:	16716	Length:	1265	Species:	Homo sapiens

Alignment Length:	795	Identity:	229/795 - (28%)
Similarity:	385/795 - (48%)	Gaps:	95/795 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TQINLIEFSFLDHKAELVGL---------LQAKSRQVGRSLVENEA-----DFWKFVGKYE---- 64
            |..||::|..:..|.:|..|         ..||.|:  ::..||:|     ...|.:|..:
Human   332 TAKNLMQFHTVGTKTKLSTLTLLWPCPMTFVAKGRR--KAEAENKAAALACKKLKSLGLVDRNNE 394

  Fly    65 ---------AMMRSTGQPVLPP---RLAEAELSSMQPY--H---RSKHLA--LRLDADELLQEAR 110
                     |.:|..|:....|   ::.|..|..::.:  |   .|..:|  |||.:|::|...:
Human   395 PLTHAMYNLASLRELGETQRRPCTIQVPEPILRKIETFLNHYPVESSWIAPELRLQSDDILPLGK 459

  Fly   111 DQMQSQFRHILLVYLDFRQTEKFQRIRKLRQTQR----------NLPIARFRKDLREALDTSRVV 165
            |............|:...:.|:.:..:.|.:..|          .||:...|..:..|::...||
Human   460 DSGPLSDPITGKPYVPLLEAEEVRLSQSLLELWRRRGPVWQEAPQLPVDPHRDTILNAIEQHPVV 524

  Fly   166 IVAGDTGCGKSTQVPQYLYD------FGYR-SIACTQPRRLACVSLCKRVAHELLDDYGSRVAFQ 223
            :::|||||||:|::||.|.:      .|.| ::..|||||::.||:.:||:|||.......|.||
Human   525 VISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQ 589

  Fly   224 IRFE-RSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARP 287
            :|.| :..::...:||.|.|:|||:|....:|:....:|:||:|||::..||||.:.|.|.|..|
Human   590 VRLESKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNP 654

  Fly   288 QLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYLPPPALELKAGQATSKRSQRNRID 352
            .|:|:|||||.:.|.|..|||  |..:::|||.::|:|..||.....:|...|...:.......|
Human   655 ALRLVLMSATGDNERFSRYFG--GCPVIKVPGFMYPVKEHYLEDILAKLGKHQYLHRHRHHESED 717

  Fly   353 PAPF-----VQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHE-YATEQTHWLVLPLHSGQ 411
            ....     ..::..||.:   .|.|.:|.|:.|..||:.|.:.:.| ....::.:|:||:||..
Human   718 ECALDLDLVTDLVLHIDAR---GEPGGILCFLPGWQEIKGVQQRLQEALGMHESKYLILPVHSNI 779

  Fly   412 AIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSK 476
            .:.||..:|...|.|:||.:::|||||||:|::.:..|||||..||..:|...|...|:..|||:
Human   780 PMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCLETVWVSR 844

  Fly   477 SSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPF-- 539
            ::..||:|||||...|..:.|:...:......:..|||.|.||:.::|| ..:.:|:..|..|
Human   845 ANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQ-AKIHMPEKTAVEFLS 908

  Fly   540 --IEAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTL 602
              :::|..:.:::.::.|::...|...|.:|.||:.||::..:..:.|.:::.::|..:..||.:
Human   909 KAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVV 973

  Fly   603 AAMLS---VQNPLTNRAHTDQRCVRERESLESDHG-DLFTLVRLYNVWVQLKMRRDGTRQWCRRL 663
            .:.|:   ..:.|.|||..|    :.:..|..|.| |....||....|.::...:|.:   .|..
Human   974 VSCLTRDPFSSSLQNRAEVD----KVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRS---SREN 1031

  Fly   664 GIEEQRFYE-----VTKLRQQF-QRILESCGMVVASDSDSQLTSAERATRHGELRQLKAMKRRQR 722
            .:||...|.     :..|.:|| :.|.|:  .:|...||..|.||:......|...:|.:.....
Human  1032 YLEENLLYAPSLRFIHGLIKQFSENIYEA--FLVGKPSDCTLASAQCNEYSEEEELVKGVLMAGL 1094

  Fly   723 FE---QPRQRKLLKQ 734
            :.   |.||.|:.:|
Human  1095 YPNLIQVRQGKVTRQ 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	74/179 (41%)
		DEXDc	163..298	CDD:238005	61/142 (43%)
		Helicase_C	358..490	CDD:278689	51/132 (39%)
		HA2	560..640	CDD:214852	21/83 (25%)
		OB_NTP_bind	<792..897	CDD:285018
DHX30	XP_011531792.1	HrpA	494..>1143	CDD:224557	195/631 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820